ABSTRACT
The presence of helium and argon in gas mixtures increases the peroxidation rate of lipids in homogenates and has no influence on this index in the mitochondrial and microsomal fractions of the rat liver. An assumption is advanced that the realization of effects of the inactive gases in question is realized via the plasma membranes of cells.
Subject(s)
Lipid Peroxidation/drug effects , Liver/metabolism , Noble Gases/pharmacology , Animals , In Vitro Techniques , Liver/drug effects , Male , Microsomes, Liver/drug effects , Microsomes, Liver/metabolism , Mitochondria, Liver/drug effects , Mitochondria, Liver/metabolism , Nitrogen/pharmacology , Oxygen/pharmacology , Rats , Rats, Inbred StrainsABSTRACT
The effects of helium and argon, inert gases, on oxygen consumption have been studied on liver tissue of white rats who were delivered different fatty products plus to basic food). It is shown that the effects of helium and argon on the tissue respiration depend on the nature of fatty products. The role of membrane structure in realization of the influence of inert gases on tissue respiration is under discussion.
Subject(s)
Argon/pharmacology , Dietary Fats/administration & dosage , Helium/pharmacology , Liver/metabolism , Nitrogen/pharmacology , Oxygen Consumption/physiology , Animals , Cholesterol, Dietary/administration & dosage , Fatty Acids/administration & dosage , In Vitro Techniques , Liver/drug effects , Male , Oxygen Consumption/drug effects , RatsABSTRACT
The effect of inert helium and argon gases on the tissue respiration has been studied on lymphocyte suspensions of white rats. It is shown that normoxic helium-oxygen mixture induces almost a two-fold increase of the O2 uptake by lymphocytes as compared with the control (air). No deviations in the value of the studied parameter are revealed in case of replacement of nitrogen from air by argon. Significance of the membrane structure in realization of effects of inert gases is under discussion.