Parents' Awareness and Attitude Toward Pediatrics Eye Diseases in Makkah, Saudi Arabia: A Cross-Sectional Study.

BACKGROUND: The necessity of early detection and parents' knowledge of pediatric eye conditions and eye care is crucial, not only because of the severe complications it can carry, like blindness, but also due to the availability of preventive measures and the importance of vision in a child's growth and social life. Therefore, this study aimed to evaluate the level of awareness of and attitudes toward children's eye diseases of parents in Makkah City, Saudi Arabia. METHODS:  This descriptive, cross-sectional questionnaire-based study was conducted in Makkah, Saudi Arabia, from September to December 2022. A self-administered questionnaire was randomly distributed to fathers and mothers of children younger than 18 through social media platforms. RESULTS:  A total of 470 parents who met the study's inclusion criteria completed the study questionnaire. The results showed that 72.8% of the parents had poor awareness of pediatric eye diseases, 24.5% had good awareness, and 2.8% had excellent awareness. With regard to the symptoms that might prompt parents to take their children to an eye specialist, eye redness had the highest percentage (24.5%). It was also shown that 68.5% would allow their children to undergo eye surgery, if necessary, while most of those who refused to do so (11.3%) cited fear of the surgical outcome as the cause of their refusal. CONCLUSION:  Our study findings show inadequate parental knowledge about common pediatric eye diseases and eye care practices for children. Therefore, awareness and education programs targeting both parents are recommended to raise the parents' level of awareness of pediatric eye diseases and to improve their attitudes toward the same.

A Cross-Sectional Study of the Knowledge, Practice, and Attitude Towards Herpes Zoster Vaccination Among the General Population in the Western Region of Saudi Arabia.

Introduction Herpes zoster (HZ) is a viral infection that occurs due to the reactivation of the varicella-zoster virus. The vaccination against herpes zoster to prevent its complications has been approved for individuals 50 years of age and older. This study aims to evaluate the knowledge, attitudes, and habits of at-risk populations about the varicella-zoster virus and its vaccination. Methodology A quantitative, observational, cross-sectional study was conducted among 500 adults over 50 years of age. Participants were selected by non-probability, convenience sampling from public places. RStudio (R version 4.1.1) was used to analyze the data. Result Eighty-three percent (n = 416) of participants had heard of herpes zoster (HZ). Seventy-four percent of respondents (n = 368) did not recognize the link between varicella and herpes zoster. Multiple linear regression showed that individuals who had varicella and heard about herpes zoster were the only positive predictors of herpes zoster knowledge. Out of all the respondents, 55.8% (n = 279) had heard of the herpes zoster vaccine, but 94.6% (n = 473) had not taken it. Among the respondents, 28.1% (n = 118) were unwilling to take optional vaccines; 77.4% (n = 387) agreed to take the HZ vaccine if recommended by a healthcare professional. Conclusion The general Saudi population had a good understanding of HZ and its vaccine. Their attitudes toward the HZ vaccine were generally positive; however, poor practices were observed. We recommend that arranging national campaigns targeting at-risk populations can enhance awareness about herpes zoster and its vaccine, subsequently increasing the rate of HZ immunization.

Awareness Regarding Diabetic Retinopathy Among Adult Diabetic Patients in Al Qunfudah District.

Background Diabetes mellitus is a major public health problem worldwide. Diabetic patients may suffer many complications including diabetic retinopathy, which can lead to blindness if left undiagnosed and untreated. Methodology A cross-sectional analytical study was conducted among a sample of 251 adult diabetic patients in the Al Qunfudah district. A self-administrated questionnaire was used for data collection and consisted of the following three sections: sociodemographic data, diabetes mellitus, and diabetic retinopathy-related data. Results Out of the 251 participants, 68.5% recognized that diabetes mellitus can cause eye disorders, and 72.5% of the participants knew that regular eye examinations are recommended for diabetic patients. Adequate knowledge score was observed among diabetic patients aged 25-49 years (52.6%), with a university education (53.5%), with a history of diabetes for 10 years and more (60.5%), those on insulin therapy (55.3%), those adherent to their regular treatment (92.1%), and those getting their information from doctors (73.7%). Conclusions Diabetic patients had average knowledge about diabetic retinopathy but little awareness regarding the frequency of regular eye examinations and the physicians who should conduct them. Intensive health education concerning diabetic retinopathy should be conducted for diabetic patients and their caregivers to improve their perception and compliance with eye care and prevent visual damage in the Al Qunfudhah district.

Rationales and uncertainties for aspirin use in COVID-19: a narrative review.

OBJECTIVES: To review the pathophysiology of COVID-19 disease, potential aspirin targets on this pathogenesis and the potential role of aspirin in patients with COVID-19. DESIGN: Narrative review. SETTING: The online databases PubMed, OVID Medline and Cochrane Library were searched using relevant headlines from 1 January 2016 to 1 January 2021. International guidelines from relevant societies, journals and forums were also assessed for relevance. PARTICIPANTS: Not applicable. RESULTS: A review of the selected literature revealed that clinical deterioration in COVID-19 is attributed to the interplay between endothelial dysfunction, coagulopathy and dysregulated inflammation. Aspirin has anti-inflammatory effects, antiplatelet aggregation, anticoagulant properties as well as pleiotropic effects on endothelial function. During the COVID-19 pandemic, low-dose aspirin is used effectively in secondary prevention of atherosclerotic cardiovascular disease, prevention of venous thromboembolism after total hip or knee replacement, prevention of pre-eclampsia and postdischarge treatment for multisystem inflammatory syndrome in children. Prehospital low-dose aspirin therapy may reduce the risk of intensive care unit admission and mechanical ventilation in hospitalised patients with COVID-19, whereas aspirin association with mortality is still debatable. CONCLUSION: The authors recommend a low-dose aspirin regimen for primary prevention of arterial thromboembolism in patients aged 40-70 years who are at high atherosclerotic cardiovascular disease risk, or an intermediate risk with a risk-enhancer and have a low risk of bleeding. Aspirin's protective roles in COVID-19 associated with acute lung injury, vascular thrombosis without previous cardiovascular disease and mortality need further randomised controlled trials to establish causal conclusions.

Prevalence and associated risk factors of postpartum depression: a cross sectional study

Abstract Background Postpartum mood disturbance affects up to 85% of women, with most symptoms of this disturbance being temporary and mild. However up to one in seven women experience a persistent type of depression which is associated with major maternal and neonatal morbidity if it is not managed. Objective To estimate the prevalence of postpartum depression and to identify the associated risk factors. Methods A cross sectional study was conducted in randomly selected 3 primary health care centers affiliated to Suez governorate, Egypt. An interviewed questionnaire was used containing potential risk factors for postpartum depression. An Arabic version of the Edinburgh postnatal depression scale (EPDS) was used to screen for postpartum depression symptoms. Results A total of 237 postpartum mothers were included in the study. 139 (58.6%) of the mothers completed secondary level of education, 195 (82.3%) of them were housewives and 181 (76.4%) had cesarean section. The estimated postpartum depression prevalence was 26.6% and suicidal ideation accounted for 4.6%. Factors significantly associated with high EPDS scores were bad relationship with the husband, having >2 children, an unplanned pregnancy and unhealthy newborn; with P-values of 0.000, 0.004, 0.000, and 0.018, respectively. Discussion the prevalence of postpartum depression among Egyptian women is considered slightly high with its negative and long term consequences on the mothers and their children, accordingly screening, proper management & referral to specialist care is highly recommended.

Hepatitis B Vaccine: Assessment of Immunologic Response, Coverage Rate, and Factors Influencing Seroreactivity.

BACKGROUND: Hepatitis B infection and resulting health sequela is a worldwide health problem. Adults at increased risk of infection are recommended to receive hepatitis B vaccine for protection, followed by postvaccination titer testing to confirm immunity. The aim of this study is to assess coverage rate and immunologic response to hepatitis B vaccine and factors influencing seroreactivity. METHODS: This was a cross-sectional study carried out among medical doctors of Makkah city, medical interns, and medical students of Umm Al-Qura University, Saudi Arabia. A self-administered questionnaire was used to collect data for evaluation of hepatitis B vaccination coverage, immune status, and associated risk factors. RESULTS: Three hundred twenty-one (79.9%) out of 402 participants received the vaccination. Of those vaccinated 159 (48.3%) had subsequent testing for anti-HBs. One hundred thirty-nine (87.4%) had an appropriate immunologic response to the vaccine (titer ≥ 10 mIU/mL). Factors negatively influencing seroreactivity were male gender, high BMI, smoking, incomplete vaccination series, vaccination schedule non-adherence, and long elapsed time since last vaccination; with p-values of 0.001, 0.000, 0.002, 0.001, 0.037, and 0.000, respectively. CONCLUSIONS: Hep B vaccination coverage in our study is considered insufficient. Smoking and obesity were modi-fiable and preventable risk factors negatively affecting the immunologic response. The development and enforcement of better health policies aimed at increasing access and coverage of the HBV vaccination of at-risk populations like medical students, with increased awareness, is recommended.

Association of CXCR4 Expression and Clinical Outcome in Different Subsets of De Novo Acute Myeloid Leukemia Patients.

BACKGROUND: Acute myeloid leukemia is a heterogeneous group of diseases characterized by the uncontrolled proliferation of hematopoietic stem cells (HSCs) and progenitor cells with a reduced capacity to differentiate into mature cells. CXC chemokine receptor (CXCR4) and its ligand stromal derived factor-1 (SDF-1/CXCL12) are important players involved in cross-talk between leukemia cells and the bone marrow (BM) microenvironment. The aim to study the association between the immunohistochemical CXCR4 expression and the clinical outcome of AML in adult Egyptian patients. METHODS: Fifty-eight patients suffering from AML were recruited for this study, with an age range from 18 to 60 years and presenting from January 2013 to March 2017. All patients were subjected to complete blood count, BM aspiration, immunophenotyping, BM trephine biopsy, immunohistochemical staining with CXCR4 McAb and cytogenetics when feasible. RESULTS: CXCR4 was widely expressed (55.2%) among the studied patients. There was a significant relationship between CXCR4 and patients' outcomes. Fifteen (71.4%) patients who died were CXCR4 positive. The estimated mean time until death among CXCR4 negative cases was 37.6 ± 4.04 months which was longer than that of CXCR4 positive cases who had mean of 20.04 ± 4.9 months p = 0.016. The risk for death among CXCR4 positive cases was higher than CXCR4 negative cases with hazard ratio (HR) = 2.147 (p = 0.048). CONCLUSIONS: These results suggest that CXCR4 was expressed in a subset of AML patients and was associated with poor prognosis. CXCR4 expression appears to be an independent prognostic factor for survival in a heterogeneous group of AML patients.

Prevalence of sleep disorders among medical students of Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.

Background: Sleep disorders are a common medical problem and can affect health and quality of life. There are multiple types of sleep disorders such as obstructive sleep apnea, insomnia, narcolepsy, restless legs/periodic limb movement disorder, circadian rhythm disorders, sleepwalking and nightmares. Medical students appear to be more liable to develop sleep disorders due to their high academic load. Design and Methods: This study seeks to estimate the prevalence of sleep disorders among Umm Al-Qura University medical students and associated risk factors. This cross-sectional study was conducted at the Faculty of Medicine of Umm Al-Qura University in Makkah, Saudi Arabia. A self administrated questionnaire was used to collect the data including socio-demographic data and sleep-50 questionnaire. Four hundred and thirty-eight (438) medical students from the second year to the sixth year were recruited to the study Results: Three hundred and twenty-three participants (73.8%) complained of at least one sleep disorder. The most prevalent sleep disorder among students was narcolepsy at 226 (51.6%). Female students, second year students and students spending significant time watching television or on smartphones were more affected than others with p values of 0.001, 0.005, and 0.004 respectively. Conclusions: Sleep disorders are common among medical students. It is essential to detect and address them before their condition deteriorates.

Mortality rate of ICU patients with the Middle East Respiratory Syndrome - Coronavirus infection at King Fahad Hospital, Jeddah, Saudi Arabia.

OBJECTIVE: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a novel coronavirus circulating in the Arabian Peninsula since September 2012. It leads to significant respiratory disease and among patients with co-morbidities is associated with high mortality. This research studied the mortality rate of MERS-CoV among intensive care unit (ICU) patients and the correlation of mortality with different co-morbidities. METHODS: This was a retrospective observational study conducted at the Intensive Care Unit of the King Fahad Hospital, Jeddah, Saudi Arabia. Data was obtained through patient chart review. RESULTS: The total sample consisted of 52 laboratory-confirmed MERS-CoV infection patients. 39 patients died, with a 75% case-fatality rate. Many patients had underlying co-morbidities, including diabetes mellitus (51.9%), hypertension (46.2%), and chronic renal disease (21.2%). CONCLUSIONS: MERS-CoV ICU mortality remains markedly high due to a combination of factors; the disease process of MERS-CoV leads to multiple organ failure, particularly respiratory and renal failure.