Local anaesthetic resistance in a patient with Ehlers-Danlos syndrome undergoing caesarean section with continuous spinal anaesthesia.

A patient with a diagnosis of Ehlers-Danlos syndrome was scheduled to undergo elective caesarean section with a combined spinal-epidural anaesthetic technique. The epidural attempt resulted in an inadvertent dural puncture, and we decided subsequently to place an intrathecal catheter. She required high repeated doses of hyperbaric bupivacaine (32.5 mg over 1 h) through the catheter to establish adequate sensory blockade, together with supplemental analgesic techniques. Soon after the procedure, she recovered motor function rapidly and required further supplemental analgesia. We believe this is the first report of possible local anaesthetic resistance with an intrathecal catheter anaesthetic technique for a patient with Ehlers-Danlos syndrome. If there is resistance to the first dose of intrathecal local anaesthetic, a general anaesthetic may be the best option for such patients.

Early vs. standard unclamping technique in minimal access partial nephrectomy: a meta-analysis of observational cohort studies and the Lister cohort.

To evaluate if early unclamping (EUC) of the renal pedicle compromises perioperative outcomes in minimally invasive partial nephrectomy (PN). The cohort study includes all robot-assisted PN performed between September 2012 and September 2015 by a single surgeon at the Lister Hospital, Stevenage, UK. The systematic review and meta-analysis was performed according to the PRISMA guidelines identifying studies comparing EUC and standard unclamping (SUC) in either laparoscopic or robot-assisted PN. The Lister cohort prospectively reported 84 cases of robot-assisted PN (SUC = 22, EUC = 62) with a mean age of 58 years (SD = 11). The operative time (OT), estimated blood loss (EBL) and warm ischaemia time (WIT) were 186.5 min (SD = 33.8), 125.5 mls (SD = 188.91) and 16.7 min (SD = 5.6), respectively. The data from the Lister cohort were included in the meta-analysis. The systematic review identified four studies, encompassing 666 cases (313 SUC, 353 EUC), for inclusion in the final analysis. There was a statistically significant difference in WIT in favour of the EUC group [-10.59 min (95% CI -16.58, -4.60)]. Specifically, the reduction in WIT was more pronounced in laparoscopic PN (-15.43 min (95% CI -19.05, -11.81)), when compared with the robotic PN [-5.60 min (95% CI -5.70, -5.50)]. There was no statistical difference in OT [-3.97 min (95% CI -14.22, 6.28)]. EBL was found to be increased in the EUC group [71.39 ml (95% CI -0.78, 143.56)]. There was no statistically significant difference in transfusion rates or complications between the two groups. The EUC technique for robot-assisted PN appears to offer a safe limited period of WIT without compromising perioperative outcomes and morbidity.

The physiologic and anesthetic considerations in elderly patients undergoing robotic renal surgery.

A number of patients are diagnosed with renal malignancies incidentally worldwide. Once a diagnosis of a renal malignancy is established, after a careful evaluation, patients can be offered a robotic nephrectomy or partial nephrectomy. We present a review of the physiologic and anesthetic considerations in elderly patients who are being considered for robotic renal surgery.

A prospective observational study of the subjective experience of caesarean section under regional anaesthesia.

The aim of our study was to determine the subjective sensation of caesarean section under regional anaesthesia. We performed a prospective, observational study of 205 patients undergoing caesarean section under regional anaesthesia in a UK district general hospital. Patients were asked open and closed questions relating to their physical and emotional experience during the operation. Seventy-three percent of patients chose the phrase "pulling and pushing" to describe the physical sensation of the operation, 75% described the experience as pleasant, and only 4% described it as unpleasant, the rest saying it was neither pleasant nor unpleasant. Ninety-six percent said they would by choice have any future caesarean section under regional anaesthesia, 3% were undecided and 1% said they would prefer a general anaesthetic next time. This study provides important precise information that may be given to patients before caesarean section under regional anaesthesia. We believe it will help minimise preoperative fears and increase patients' ability to make informed decisions about their care.

Continuous caudal analgesia in labour for a patient with Harrington rods.

We report the case of a 29-year-old patient who had Harrington rods inserted from T8 to L4 at the age of 14. She had been discouraged from having epidural anaesthesia in the antenatal clinic but, whilst in labour, requested analgesia in addition to Entonox and pethidine. Continuous caudal analgesia was commenced and provided good pain relief for labour and delivery.

The estimation of inspired desflurane concentration in a low-flow system.

We have examined the predictability of inspired desflurane concentration during low-flow anaesthesia using a to-and-fro breathing system. Twenty-two adult patients requiring mechanical ventilation of the lungs during surgery took part in the study. Using a fresh gas flow of 1 l.min-1, the ratio of inspired desflurane concentration to desflurane vaporizer setting was found to be approximately 0.75 after 9 min of anaesthesia and at 2 l.min-1 fresh gas flow the ratio was approximately 0.9 after 2 min of anaesthesia. These ratios were maintained throughout the procedure, except for a few minutes following each change in vaporizer setting.

The estimation of inspired isoflurane concentration in a low-flow system.

We have examined the predictability of inspired isoflurane concentration during low-flow anaesthesia using a to-and-fro breathing system. Twenty one adult patients requiring mechanical ventilation of the lungs during surgery took part in this study. Using a fresh gas flow of 2 l.min-1, the ratio of inspired isoflurane concentration to isoflurane vaporizer setting was found to be approximately 4/5th after 5 min of anaesthesia. The ratio was maintained throughout the procedure, except for a few minutes following each change in vaporizer setting.