ABSTRACT
The purpose of this research was to develop oro-dispersible tablets of metformin by direct compression method using super disintegrants approach, effervescent approach and sublimation approach. Powder blend was evaluated for angle of repose, bulk density, tapped density, compressibility index, Hausner's ratio and bulkiness. The tablets were evaluated for uniformity of weight, friability test, hardness, drug content, wetting time, water absorption ratio, disintegration time and in vitro dissolution. Higher dissolution rates were achieved in selected batches (A5, B4, C4, and D3) as compared to marketed product. Batch C4 prepared by effervescent approach was found to have the least disintegration time and maximum in vitro dissolution profile.
Subject(s)
Hypoglycemic Agents/administration & dosage , Metformin/administration & dosage , Absorption , Administration, Oral , Algorithms , Chemistry, Pharmaceutical , Drug Compounding , Hardness , Hypoglycemic Agents/chemistry , Kinetics , Metformin/chemistry , Powders , Solubility , Tablets , WaterABSTRACT
Unilateral musculoskeletal below-knee injuries occur with great frequency. Patients who cannot bear weight on an injured limb usually mobilize themselves with standard crutches. When the patient also has an upper limb injury, however, mobilization might be impossible, and can result in a lengthy in-patient stay. A randomized control trial was conducted on 80 patients to share our experience with the innovative 'hands-free crutch', and to discuss the potential of this device for more frequent use in orthopaedic surgery. We present its value in facilitating early discharge in patients with both upper and lower limb injuries. We show the cost benefit of the decreased in-patient stay that the hands-free crutch provides.
