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Eur J Immunogenet ; 31(1): 1-3, 2004 Feb.
Article in English | MEDLINE | ID: mdl-15009173

ABSTRACT

The mouse CD1 system is formed by two closely related genes named Cd1d1 and Cd1d2. Cd1d1 encodes a molecule that presents antigens to NKT cells. The function of the Cd1d2 gene has not been elucidated. Here we described a method to analyse variations in mouse Cd1 genes. We found a new allele for Cd1d2 characterized by a point mutation, resulting in a replacement of alanine at position 176 by a valine.


Subject(s)
Antigens, CD1/genetics , Alanine/chemistry , Alleles , Amino Acid Sequence , Animals , Antigens, CD1d , Base Sequence , Genetic Variation , Mice , Mice, Inbred BALB C , Mice, Inbred C57BL , Mice, Inbred NOD , Molecular Sequence Data , Point Mutation , Polymerase Chain Reaction , Polymorphism, Genetic , Polymorphism, Single-Stranded Conformational , Sequence Analysis, DNA , Sequence Homology, Nucleic Acid , Valine/chemistry
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