ABSTRACT
We compared platelet aggregation with changes in fibronectin (FN) plasma levels in children with various forms of primary CGN. We found that a rise in platelet aggregation and plasma FN level depends on CGN clinical form, extent of inflammation and sclerotic changes in nephric tissue. The greatest changes occurred in patients with nephrotic CGN and with segmentary glomerulosclerosis.
Subject(s)
Fibronectins/blood , Glomerulonephritis/blood , Platelet Aggregation , Adenosine Diphosphate , Adolescent , Child , Child, Preschool , Chronic Disease , Hematuria/blood , Humans , Nephrotic Syndrome/blood , Platelet Aggregation/drug effectsABSTRACT
The structure of the extracellular matrix (ECM) in the kidney glomeruli in different variants of glomerulonephritis (GN) was studied using immunofluorescence. Mesangial sclerosis and synthesis of the interstitial collagen, type I and III, were found to be a peculiar feature of mesangioproliferative and mesangiocapillary GN. Location of sclerosis predominantly in the basal membranes of the peripheral capillary loops was typical for membranous GN. Restructuring of ECM in minimal changes and focal-segmentary glomerulosclerosis is limited by an increase of fibronectin in the mesangium and peripheral capillary loops of the glomeruli. The development of pronounced sclerosis and hyalinosis of glomeruli as well as the formation of the crescents are the most marked ECM restructuring signs regardless of GN form.
Subject(s)
Glomerulonephritis/pathology , Glomerulosclerosis, Focal Segmental/pathology , Adolescent , Child , Child, Preschool , Fibronectins/metabolism , Fluorescent Antibody Technique , Glomerulonephritis/metabolism , Glomerulonephritis, Membranoproliferative/pathology , Glomerulonephritis, Membranous/pathology , Glomerulosclerosis, Focal Segmental/metabolism , Humans , Nephrosis, Lipoid/pathologyABSTRACT
The level of plasma fibronectin (FN) is increasing in prognostically unfavourable morphological forms of childrens glomerulonephritis being in direct relationship with the activity index and sclerosis index. Urine FN excretion depends upon generalization of the tubulointerstitial changes, presence in the kidney of synechia and segmentary sclerosis of the glomeruli capillaries. A direct correlation is established between FN in the renal tissue and the degree of the mesangial cell proliferation and the spread of sclerotic changes.
Subject(s)
Fibronectins/metabolism , Glomerulonephritis/metabolism , Kidney/metabolism , Adolescent , Child , Child, Preschool , Fibronectins/blood , Fibronectins/urine , Glomerulosclerosis, Focal Segmental/metabolism , Humans , Kidney/pathology , PrognosisABSTRACT
As many as 91 children with the nephrotic and hematuric forms of primary chronic glomerulonephritis were examined for the presence of streptococcal infection and allergic diseases. It has been shown that as compared to patients with the hematuric form of chronic glomerulonephritis, those with the nephrotic form manifest a higher occurrence of A3, a dramatic rise of serum IgE and its dependence on the activity of glomerulonephritis. The data obtained may attest to the etiological role played by allergy in the development of the nephrotic form of glomerulonephritis. Frequently occurring colonization of hemolytic streptococcus in the fauces and the rise of the ASL-O titer in the blood serum seen in patients with the hematuric form of glomerulonephritis, its dependence on the disease activity suggest the streptococcal etiology in patients with that form in contrast to those with the nephrotic form.