ABSTRACT
Papillary thyroid carcinoma (PTC) is the most differentiated malignant thyroid neoplasm. Local metastases of PTC commonly occur in the regional lymph nodes, while distant metastases are mainly to the lung and bone. The case of a patient with PTC who presented with swelling of the parotid gland and neck, mimicking a primary parotid neoplasm, is presented herein. This case is unique due to the unexpected initial presentation of PTC with no signs of disease in the thyroid gland.
Subject(s)
Adenocarcinoma/diagnostic imaging , Adenocarcinoma/secondary , Carcinoma, Papillary/diagnostic imaging , Carcinoma, Papillary/pathology , Parotid Neoplasms/diagnostic imaging , Parotid Neoplasms/secondary , Thyroid Neoplasms/diagnostic imaging , Thyroid Neoplasms/pathology , Adenocarcinoma/surgery , Biomarkers, Tumor/analysis , Biopsy, Fine-Needle , Carcinoma, Papillary/surgery , Diagnosis, Differential , Humans , Immunohistochemistry , Male , Middle Aged , Neck Dissection , Parotid Neoplasms/surgery , Thyroid Cancer, Papillary , Thyroid Neoplasms/surgeryABSTRACT
OBJECTIVES: To investigate the anti-inflammatory, anti-oxidative and tissue protective effects, as well as the potential therapeutic role, of alpha-lipoic acid in experimentally induced acute otitis media. METHODS: Twenty-five guinea pigs were assigned to one of five groups: a control (non-otitis) group, and otitis-induced groups treated with saline, penicillin G, alpha-lipoic acid, or alpha-lipoic acid plus penicillin G. Tissue samples were histologically analysed, and oxidative parameters in tissue samples were measured and compared between groups. RESULTS: The epithelial integrity was better preserved, and histological signs of inflammation and secretory metaplasia were decreased, in all groups compared to the saline treated otitis group. In the alpha-lipoic acid plus penicillin G treated otitis group, epithelial integrity was well preserved and histological findings of inflammation were significantly decreased compared to the saline, penicillin G and alpha-lipoic acid treated otitis groups. The most favourable oxidative parameters were observed in the control group, followed by the alpha-lipoic acid plus penicillin G treated otitis group. CONCLUSION: Alpha-lipoic acid, with its antioxidant, anti-inflammatory and tissue protective properties, may decrease the clinical sequelae and morbidity associated with acute otitis media.
