Improving diabetes care among patients with severe mental illness: A systematic review of the effect of interventions.

BACKGROUND AND AIM: Individuals with severe mental illness (SMI) who suffer from type 2 diabetes (T2DM) are likely to be sub-optimally treated for their physical condition. This study aimed to review the effect of interventions in this population. METHODS: A systematic search in five databases was conducted in July 2017. RESULTS: Seven studies on multi-faced interventions were included. These comprised nutrition and exercise counselling, behavioural modelling and increased disease awareness aiming to reduce HbA1c, fasting plasma glucose, body mass index and weight. CONCLUSION: Non-pharmacologic interventions in individuals with SMI and T2DM could possibly improve measures of diabetes care, although with limited clinical impact.

5' Analysis of the soybean leghaemoglobin lbc(3) gene: regulatory elements required for promoter activity and organ specificity.

The soybean leghaemoglobin lbc(3) gene promoter was analysed in transgenic Lotus corniculatus plants. Hybrid-promoter constructions and 5' deletions were studied using chimeric genes composed of the various promoters, the chloramphenicol acetyltransferase (CAT) coding sequence and the lbc(3) 3' flanking region. A 5' Bal31 deletion series mapped a strong positive regulatory element between -1100 and -950. A weaker element located between -230 and -170 defined the minimum 5' region required for detectable promoter activity. Reactivation of inactive promoters with deletion endpoints between -230 and the transcription initiation site was obtained employing the constitutive cauliflower mosaic virus (CaMV) 35S enhancer. The position of cis regulatory element(s) required for nodule-specific expression was defined to 37 bp between -139 and -102. This region contains sequences conserved in other leghaemoglobin and nodulin genes. No indispensable control elements were found on the lbc(3) 3' flanking region.

[Obturating thrombophlebitis as a complication of prolonged subclavian vein catheterization]. / Obturiruiushchii tromboflebit kak oslozhnenie dlitel'noi kateterizatsii podkliuchichnykh ven.

Catheterization of subclavian veins was performed in 2800 patients including 18 children in order to fulfil infusion-transfusion massive antibacterial therapy. The article gives a detailed clinical picture of the complication and recommendations for the treatment of this dangerous complication. The outcomes of the obturating thrombosis with catheterized subclavian veins are described. The employed active conservative therapy contributed to recovery of all the patients having this complication.