[Reduction of stain, plaque and gingivitis by mouth rinsing with chlorhexidine and peroxyborate]. / Afname van verkleuring, plaque en gingivitis door combinatie van chloorhexidine en oxyperboraat.

Aim of the present study was to investigate whether the use of an oxidising mouthrinse as an adjunct to chlorhexidine is efficacious in reducing stain, plaque and gingivitis. This study had a single-blind, 2-group parallel design, including a 14-day experimental non-brushing period during which 1 group (n = 14) used chlorhexidine alone (CHX) and the other (n = 14) used chlorhexidine in combination with an oxidising agent. Patients were randomly assigned to either group. The gingival condition was evaluated at baseline by means of bleeding on marginal probing. The examination after 14 days of rinsing included the evaluation of plaque, bleeding on marginal probing and stain (GMSI: gingival modification of the stain index). The results showed at day 14 a significant difference between the 2 groups for plaque and gingival bleeding. The proportion of stained surfaces was less in the CHX + PER-group (28%), than in the chlorhexidine group. The adjunctive use of an oxidising agent peroxyborate to chlorhexidine, proved to be superior to chlorhexidine alone with regard to the inhibition of plaque and development of gingivitis.

Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate.

BACKGROUND: Previous studies have shown that using an oxidising agent in addition to chlorhexidine reduces staining. AIM: The purpose of the present study was to investigate whether, compared to chlorhexidine alone, the use of an oxidising mouthrinse as an adjunct to chlorhexidine is efficacious in reducing stain, plaque and gingivitis. METHOD: This study had a single-blind, 2-group parallel design, including a 14-day experimental non-brushing period during which 1 group (n= 14) used chlorhexidine alone (CHX) (chlorhexidine mouthrinse, 0.12% Oral-B laboratories, Ireland), and the other (n= 14) used chlorhexidine in combination with an oxidising agent (sodiumperborate-monohydrate-Bocasan, Oral-B laboratories, Ireland). Patients were randomly assigned to either group. All participants received a scaling and polishing before the start of the trial. No oral hygiene instructions were given. Since, at the start of the experiment, all stain and plaque were removed, only the gingival condition was evaluated at baseline by means of bleeding on marginal probing. The examination after 14 days of rinsing included the evaluation of plaque, bleeding on marginal probing and stain (GMSI: gingival modification of the stain index). RESULTS: The results showed at day 14, a significant difference between the 2 groups for plaque (CHX: 0.18, CHX+PER: 0.08, p=0.03) and gingival bleeding (CHX: 0.38, CHX+PER: 0.21, p<0.001). The proportion of stained surfaces was less in the CHX+PER group (28%), than in the chlorhexidine group (48%) (p=0.04). CONCLUSIONS: In conclusion, the adjunctive use of an oxidising agent peroxyborate to chlorhexidine, proved to be superior to chlorhexidine alone with regard to the inhibition of plaque and development of gingivitis. In addition, the proportion of stained surfaces was significantly less when adding the oxidising mouthrinse to chlorhexidine.

The inhibitory effect of combining chlorhexidine and hydrogen peroxide on 3-day plaque accumulation.

In a blind, randomised, 4-cell, cross-over study, the effect of rinsing with a perborate solution (1.9 g sodium perborate-monohydrate dissolved in 30 ml water/Bocasan, Oral-B) on the in vivo plaque-inhibiting effect of 0.12% chlorhexidine (Oral-B) was examined. After a thorough professional prophylaxis including interdental cleaning, 12 subjects started to rinse according to 4 different regimens: regimen (C-P-C): chlorhexidine in the morning, perborate at noon and chlorhexidine in the evening; regimen (CP-CP): chlorhexidine immediately followed by perborate in the morning and in the evening; regimen (PC-PC): perborate immediately followed by chlorhexidine in the morning and in the evening; regimen (C-C): chlorhexidine in the morning and in the evening. No further oral hygiene measures were allowed for the next 72 h. After 72 h, the subjects were scored for plaque, and a washout period of 4 days followed; cross-over was randomly assigned according to a Latin square design. Following this procedure, all subjects went through all 4 regimens. The regimens C-P-C and PC-PC resulted in significantly lower plaque-scores, 0.27 and 0.28 respectively, than regimen C-C (0.40). For the regimen CP-CP, the plaque-score was 0.28, which was not significantly different from the C-C regimen. The results suggest a positive interaction between chlorhexidine and hydrogen peroxide. Rinsing with a combination of 0.12% chlorhexidine (Oral-B) and a perborate solution (Bocasan Oral-B) can result in more effective short-term plaque growth inhibition than rinsing with chlorhexidine alone.