ABSTRACT
The authors studied duodenal myoelectric activity and the activity of trypsin, alpha 1-antitrypsin, alpha 2-macroglobulin, alpha-amylase, and kallikrein after 15-minute occlusion of the hepatic portal vein. The correlation was found between the activity of alpha 1-antitrypsin and the phases of the myoelectrical complex. It is concluded that the discharge of pancreatic proteases during an operative trauma may underlie the pathogenesis of postoperative inhibition of intestinal peristalsis.
Subject(s)
Gastrointestinal Motility/physiology , Hydrolases/blood , Intestine, Small/physiopathology , Peritoneal Diseases/surgery , Postoperative Complications/etiology , Animals , Humans , Hydrolases/antagonists & inhibitors , Intestinal Diseases/enzymology , Intestinal Diseases/etiology , Male , Pancreas/enzymology , Postoperative Complications/enzymology , RatsABSTRACT
The effect of pancreas atrophy on myoelectrical activity of the duodenum and serum trypsin, trypsin inhibitor, amylase, lipase activity has been described. The activation of the duodenum motor activity has been established. The changes in the motor activity were connected with trypsin and trypsin inhibitor activity of serum. The motor activity changes were compensated by trypsin therapy.