[The modelling of acute myocardial ischemia-reperfusion in animals with a closed chest and natural breathing]. / Modelirovanie ostroi ishemii--reperfuzii miokarda u zhivotnykh s zakrytoi grudnoi kletkoi i estestvennym dykhaniem.

A new method of reproduction of myocardial ischemia and reperfusion is represented in this article. It permits studying: cardiodynamic changes accompanying the local myocardial ischemia and reperfusion under physiological conditions; changes in the retrograde blood flow from the ischemic region; changes in the reperfusion blood flow; intercoronary relations; biochemical parameters of the blood from the ischemic region of the myocardium.

[The mechanisms of the changes in coronary vascular resistance in anaphylactic shock]. / O mekhanizmakh izmenenii koronarnogo sosudistogo soprotivleniia pri anafilakticheskom shoke.

Anaphylactic shock decreased the coronary perfusion pressure, systemic arterial pressure and cardiac output in anesthetised dogs. After combined inhibition of cyclo-oxygenase and lipoxygenase with linoleate-hydroxamic acid, the anaphylactic coronary constriction and morphological cardiac lesions were considerably diminished. Activation of the lipoxygenase pathway seems to play a major role in development of the coronary constriction in anaphylaxis.

[The effect of indomethacin on the changes in the hemodynamics and coronary vascular resistance during anaphylactic shock]. / Vliianie indometatsina na izmeneniia gemodinamiki i koronarnogo sosudistogo soprotivleniia pri anafilakticheskom shoke.

The preliminary inhibition of prostanoid biosynthesis by indomethacin (10 mg/kg, intravenously) strongly changes the typical anaphylactic shock reaction produced by the intracoronary injection of the challenging dose of the antigen in the dogs sensitized with normal horse serum. A rapid fall of blood pressure and cardiac output at the first stage of the anaphylactic reaction is sharply diminished, the reaction of the coronary vessels is inversed. Instead of dilatation, vasoconstriction occurred increasing with the repeated administration of the antigen. The data obtained suggest that the initial hypotension under anaphylactic shock is due to prostanoid production while the coronary spasm is the result of lipoxygenase activation.

[The effect of the 5-lipoxygenase inhibitor quercetin on the functional and morphologic manifestations of myocardial lesions in ischemia and reperfusion of the heart]. / Vliianie blokatora 5-lipoksigenazy kvertsetina na funktsional'nye i morfologicheskie proiavleniia porazheniia miokarda pri ishemii i reperfuzii serdtsa.

In experimental canine myocardial infarction induced by an hour coronary artery occlusion, followed by 5-hour reperfusion, quercetin solution, 10 mg/kg, was demonstrated to improve left ventricular myocardial contractility, to reduce the incidence of rhythm and conduction disturbances, to promote the limitation of an ischemic lesion area, to produce a protective effect on the ultrastructure of coronary artery, contributing to the maintenance of vessel integrity, improvement of coronary blood flow, and prevention of intravascular thrombus formation.

[Disorders of cardio- and hemodynamics in endotoxic shock]. / Narusheniia kardio- i gemodinamiki pri éndotoksicheskom shoke.

Relative significance of cardiac and vessel components as well as the role of arachidonic acid metabolites in the development of endotoxic shock have been investigated in two series of experiments on the mongrel dogs. It is determined that endotoxin exerts no direct negative inotropic influence on the myocardium: blood pool in peripheral capacitance vessels plays a main role in the development of the first phase of the endotoxic shock (the first 30 min), that is a result of prostacyclin influence on these vessels, while in the subsequent phase it is a result of the bloodflow disturbance in the myocardium or arachidonic acid metabolites influence on the myocardium. Administration of endotoxin to the bloodflow significantly increased concentration of prostanoids; thromboxane A2 and prostacyclin in it. Indomethacin, inhibitor of prostaglandin synthesis, prevents development of the endotoxic shock.

[External respiration, gas exchange and blood acid-base status in dogs with hyperthermia]. / Vneshnee dykhanie, gazoobmen i kislotno-osnovnoe sostoianie krovi pri gipertermii u sobak.

Experiments on dogs have shown that hyperthermia intensifies respiration, increases oxygen consumption, induces pronounced discrepancy of the alveolar ventilation to carbon dioxide elimination, severe hypocapnia and decompensated respiratory alkalosis.

[Changes in the blood-air barrier of the lungs in hyperthermia]. / Izmeneniia aérogematicheskogo bar'era legkikh pri gipertermii.

The influence of hyperthermia on the ultrastructure of lung air-blood barrier (ABB) was studied in experiments on dogs. It was shown that in hyperthermia both mean arithmetic and mean harmonic thickness of ABB were increased. The lung capillary endothelial layer was the most thick ABB layer, in which severe micropinocytosis could be observed. Marked destructive changes were noted in lung alveolar epithelial ABB layer up to the appearance of cell content in alveolar space and denudation of the epithelial basal membrane.

[Blood oxygenation in the lungs and characteristics of the development of a hypoxic state during hyperthermia]. / Oksigenatsiia krovi v legkikh i osobennosti razvitiia gipoksicheskogo sostoianiia pri gipertermii.

The effect of 3-hr hyperthermia on the oxygen body regimen parameters and lung blood oxygenation was studied in dogs. A hypoxic state was shown to develop specific by arterial and venous hypoxemia, an imbalance between arterial oxygen transport and oxygen consumption, as well as hypocapnia and acid-base disturbances.

[Energy metabolism and myocardial contractile activity in cardiocytotoxic injury]. / Energeticheskoe obmen i sokratitel'naia aktivnost' miokarda pri kardiotsitotoksicheskom povrezhdenii.

It was established in experiments on anesthetized dogs with a closed thorax that injection of anticardiac cytotoxix serum into one of the main branches of the left coronary artery is accompanied by regional disturbances of energy metabolism, manifested by a decrease in ATP, ADP, AMP and glycogen content, and in the contractility of a injured area of the left ventricle. Undamaged myocardium of the left and right ventricles showed a compensatory hyperfunction and an increased level of noradrenaline. The energy metabolism parameters of undamaged cardiac area do not undergo any material changes.

[Study of the relation between cardiac function and the tonus of resistant vessels in experimental disorder of coronary circulation]. / Issledovanie vzaimootnoshenii mezhdu funktsiei serdtsa i tonusom rezistivnykh sosudov pri eksperimental'nom narushenii koronarnogo krovoobrashcheniia

In tests set up on dogs under morphine-chloralose anesthesia features specific for upset cardio- and hemodynamics following a primary and repeated (against the background of a preliminarily provoked myocardial infarction) acute disruption of the coronary circulation were investigated. The development of an acute ischemia of the myocardium in animals with preliminarily induced chronic disruption of the coronary circulation was shown to be attended by more intensive than in healthy dogs hemodynamic shifts and functional disorders of the heart, whereas the reflex component of the reaction, the vasodilating reactions of the peripheral vessels, in particular, proved much less marked. Possible mechanisms accounting for differences in the derangement of the cardio- and hemodynamics in primary and repeated ischemia of the myocardium are discussed.

[Functional state of the left ventricle of the heart in cardiocytotoxic shock]. / Funktsional'noe sostoianie levogo zheludochka serdtsa pri kardiotsitotoksicheskom shoke

Changes in the cardiodynamics and the contractile myocardium function under experimental shock caused by intracoronary injection of the anticardial cytotoxic serum were studied on 20 anesthetized dogs. Along with the symptoms of disturbance of the left ventricle function (a decrease of the systolic index, stroke work index of the left ventricle, rate of the intraventricular pressure rise, indices of myocardial contractility, ejection fraction) a decrease of the end-diastolic volume and pressure in the left ventricle was observed. These data show that disturbances in the cardiodynamics were cause not only by the cytotoxic heart damage, but also by derangement of the blood flow to the left heart.