ABSTRACT
The states characterized by pronounced hypercoagulable components (deep vein thrombosis, cardio- and cerebro-vascular pathologies) are caused by multiple pathophysiological factors, including insufficient supply of magnesium (Mg) and other micronutrients. AIM: to present results of analysis of the Institute of Microelements Data Base (IMDB) performed from point of view of interrelationships of Mg deficit and hypercoagulable states in adults treated in medico-preventive facilities of Central, Northwestern, Northern, and Siberian federal districts of Russia. METHODS: The analysis was realized as analysis of data obtained in a cross-sectional study. In the cohort of patients (n=1453) formed from the IMBD adequacy of Mg supply was assessed by magnesium levels in blood plasma (Mg BP) (0.69±0.15 mmol/L) and estimates of daily Mg consumption according to dietary diaries (Mg D) (185±90 mg/day). RESULTS: Mg supply was adequate (Mg BP >0.80 mmol/L, Mg D >300 mg/day) in not more than 6 % of patients. Presence of "Hypercoagulation" label in data base was associated with greater number of chronic diseases (2.3±2.1 and 0.83±0.8 with and without this label, respectively, Ñ=0.0006) and elevated risk of the presence on 4 comorbid pathologies (odds ratio [OR] 18, 95 % confidence interval [CI] 10-25, Ñ=0.0006). Mg deficit (Mg BP.
Subject(s)
Magnesium Deficiency , Adolescent , Adult , Cross-Sectional Studies , Humans , Magnesium , Middle Aged , Russia , Young AdultABSTRACT
The states characterized by pronounced hypercoagulable components (deep vein thrombosis, cardio- and cerebro-vascular pathologies) are caused by multiple pathophysiological factors, including insufficient supply of magnesium (Mg) and other micronutrients. AIM: to present results of analysis of the Institute of Microelements Data Base (IMDB) performed from point of view of interrelationships of Mg deficit and hypercoagulable states in adults treated in medico-preventive facilities of Central, Northwestern, Northern, and Siberian federal districts of Russia. METHODS: The analysis was realized as analysis of data obtained in a cross-sectional study. In the cohort of patients (n=1453) formed from the IMBD adequacy of Mg supply was assessed by magnesium levels in blood plasma (MgBP) (0.69±0.15 mmol/L) and estimates of daily Mg consumption according to dietary diaries (MgD) (185±90 mg/day). RESULTS: Mg supply was adequate (MgBP >0.80 mmol/L, MgD >300 mg/day) in not more than 6% of patients. Presence of "Hypercoagulation" label in data base was associated with greater number of chronic diseases (2.3±2.1 and 0.83±0.8 with and without this label, respectively, Ñ=0.0006) and elevated risk of the presence on 4 comorbid pathologies (odds ratio [OR] 18, 95% confidence interval [CI] 10-25, Ñ=0.0006). Mg deficit (MgBP.
Subject(s)
Diet , Magnesium Deficiency , Adolescent , Adult , Cross-Sectional Studies , Humans , Magnesium , Middle Aged , Odds Ratio , Russia , Young AdultSubject(s)
Fatty Acids, Omega-3/pharmacology , Psychotropic Drugs/pharmacology , Adult , Blood Pressure/drug effects , Electroencephalography , Fatty Acids, Omega-3/administration & dosage , Humans , Lipid Metabolism/drug effects , Male , Middle Aged , Psychological Tests , Psychotropic Drugs/administration & dosageABSTRACT
Anti-sea-sickness effect of a new homeopathic drug [see text] and its influence on operator's working capacity during Coriolis acceleration was evaluated in blind placebo-controlled investigation conducted in practically healthy volunteers with low vestibular resistance. For comparison "Dimenhydrinate" was used. The investigation has demonstrated that [see text] has rather strong anti-sea-sickness effect, is comparable with dimenhydrinate effectiveness and prevents the development of disorders in sensory-and-motor and cognitive functions during the influence of static-and- kinetic loads. According to the data obtained the protective action of [see text] is most likely connected with adaptive effect on organs and systems that form the functional protective system against sea-sickness. The negative influence of the drug on CNS complex functions was not observed that allows recommending its prophylactic use in subjects with low sea-sickness resistance including the operators.
Subject(s)
Homeopathy/methods , Materia Medica/therapeutic use , Motion Sickness/prevention & control , Adolescent , Adult , Dimenhydrinate/administration & dosage , Dimenhydrinate/therapeutic use , Female , Humans , Male , Materia Medica/administration & dosage , Middle Aged , Military Personnel , Syndrome , Treatment OutcomeABSTRACT
Psycho- and neurophysiologic investigation of 66 Navy specialists aged 18-71 has revealed the consecutive age-related worsening of different components of operators' activities with predominant and more early disorders in the processes of sensomotor coordination and attention. Apparently the age-related changes in functional state of certain cerebral areas underlie the observed disorders in operators' activities. It is supported by the results of correlation analysis between neurophysiologic and psychophysiologic indices.