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5.
Gen Pharmacol ; 14(6): 579-83, 1983.
Article in English | MEDLINE | ID: mdl-6420225

ABSTRACT

Several groups of rats were treated with dipyridamol and dihydroergotoxine methane sulphonate and their association. Their clinical constants were then monitored and their brain tissue examined by optical microscopy. This study indicates that the association has a remarkable effect on the pO2, maintaining the level of 2,3-diphosphoglycerate concentration, and moreover a vasodilatory action, facilitating a better supply of oxygen to the cerebral cells. The results show the advantage of these drugs in treating cerebral vascular disease.


Subject(s)
Brain/metabolism , Dihydroergotoxine/pharmacology , Dipyridamole/pharmacology , Oxygen Consumption/drug effects , 2,3-Diphosphoglycerate , Animals , Bicarbonates/metabolism , Brain/anatomy & histology , Brain/drug effects , Carbon Dioxide/metabolism , Diphosphoglyceric Acids/metabolism , Drug Interactions , Hematocrit , Hydrogen-Ion Concentration , Male , Rats , Rats, Inbred Strains
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