ABSTRACT
A case is reported of a patient with chronic urticaria. The correlation between the symptoms and dental treatment gave rise to the supposition that a root canal cement was causing the trouble. This hypothesis has been tested with epicutaneous patch tests and intradermal tests in cooperation with the Utrecht University Hospital (the Netherlands), Institute of Dermatology, Clinical Allergy Section. A causal relationship with eugenol, a cement constituent, could only be established through provocative oral ingestion. Nevertheless, caution is needed when dealing with chronic urticaria in view of the risk of anaphylactic reaction. Consequently, the article highlights the allergenic aspects of eugenol, as a substance associated with balsam of Peru. Attention is focused on the fact that eugenol, used in dental materials, is able to elicit and maintain urticaria protractedly.
Subject(s)
Dental Cements/adverse effects , Eugenol/adverse effects , Urticaria/chemically induced , Adult , Chronic Disease , Dental Cements/analysis , Drug Hypersensitivity/diagnosis , Female , Humans , Urticaria/etiologyABSTRACT
A case is reported of a patient with chronic urticaria. The correlation between the symptoms and dental treatment gave rise to the supposition that a root canal cement was causing the trouble. A causal relationship with eugenol, a cement constituent, could only be established through provocative oral ingestion. There is a high probability that the oral provocation tests to eugenol are relevant. Nevertheless, caution is needed when dealing with chronic urticaria.
Subject(s)
Eugenol/adverse effects , Urticaria/chemically induced , Adult , Chronic Disease , Dental Cements/analysis , Drug Hypersensitivity/diagnosis , Eugenol/analysis , Eugenol/immunology , Female , Humans , Root Canal TherapyABSTRACT
Cisapride is a newly developed substance that stimulates gastrointestinal motility, possibly enhancing acetylcholine release in the gut wall. The aim of our study was to investigate the effect of cisapride on oesophageal motor function in man. In a blind fashion and in random order six healthy volunteers received cisapride (0.5 mg/h intravenously, preceded by a three day oral loading at 10 mg tid) and matching placebo. Oesophageal contractions and lower oesophageal sphincter pressure were constantly recorded during a complete cycle of the interdigestive migrating motor complex and during two and half hours after a mixed test meal. Cisapride did not disturb the interdigestive migrating motor complex. In the fasting state the lower oesophageal sphincter pressure showed considerable interdigestive migrating motor complex phase-related variations, whereas amplitude and duration of the oesophageal contractions did not. In the dosis used cisapride was found to increase lower oesophageal sphincter pressure in the interdigestive and in the late postprandial state, but to have no effect in the early postprandial period. Amplitude and duration of oesophageal contractions were not affected by cisapride.
