ABSTRACT
The paper presents an evaluation of the results of surgical and combined treatment received by 961 patients at the Center's Clinics within 28 years. The analysis was based on 3 protocols of prospective randomized study. It dealt with assessment of the end results of surgical and combined treatment for operable rectal cancer using one preoperative hyperfractonated STD of 5-25 Gy. That was combined with local microwave hyperthermia and two radio modifiers--local microwave hyperthermia+intrarectal administration of a preparation containing metronidazolum. Due to the latter factor, the rate of 3-year relapse-free survival rose considerably. Also, loco-regional and distant metastasis incidence was cut down due to superior ablasticity of surgery.
Subject(s)
Rectal Neoplasms/mortality , Rectal Neoplasms/therapy , Combined Modality Therapy , Disease-Free Survival , Female , Humans , Male , Prospective Studies , Randomized Controlled Trials as Topic , Retrospective Studies , Survival RateABSTRACT
The values of luminescence quantum yield and duration have been measured for rhodoporphyrin XV, deoxophyllerythrin, phyllerythrin, etiochlorin, chlorin e6 and their zinc complexes as well as for bacteriochlorin and isobacteriochlorin. The effect of the structural elements, which are characteristic of the chlorophyll molecule, on the probabilities (rate constants) of primary photophysical processes has been traced. It has been shwon, in particular, that all these elements enhance the radiationless de-excitation of the lowest triplet state.
Subject(s)
Chlorophyll/analogs & derivatives , Metalloporphyrins , Zinc , Chemical Phenomena , Chemistry, Physical , Fluorescence , Molecular ConformationABSTRACT
The phosphorescence of dihydrooctaethylporphin (octaethylchlorin or OEC), of its complexes with magnesium, zinc, copper and palladium, and of zinc and palladium complexes of isobacteriooctaethylchlorin (5,6,7,8-tetrahydrooctaethylporphin with adjacent hydrogenated pyrrole rings or THOEP-ADJ) has been investigated. The phosphorescence spectra and phosphorescence excitation spectra as well as the ratio of fluorescence and phosphorescence yields and the triplet state lifetume have been measured. It has been shown that the singlet-triplet interval is about 4100 cm-1 for OEC complexes and about 4300 cm-1 for THOEP-ADJ complexes, and depends wealky on the nature of the metal atom forming the complex. The triplet level position of chlorophyll alpha is discussed. It is concluded that the maximum of chlorophyll alpha phosphorescence spectrum must be located at 895 nm.