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Bioorg Med Chem Lett
; 13(16): 2641-5, 2003 Aug 18.
Article
in English
| MEDLINE
| ID: mdl-12873484
ABSTRACT
We report the synthesis and pharmacological evaluation of new derivatives of the natural dipeptide antibiotic TAN 1057 A,B containing heterocycles either in the beta-amino acid side chain or as mimics of the urea function. In the course of this program, we identified novel analogues that display activity towards a broader panel of Gram-positive bacteriae.