ABSTRACT
BACKGROUND: Renal and splenic infarctions are close entities, with few data concerning their clinical, biological and radiological features. AIM: The aim of this study was to compare the clinical presentations, etiologies and outcomes of acute renal infarctions (RI) and splenic infarctions (SI). DESIGN: A retrospective multicentric cohort study included patients of the 6 university hospitals in Lyon with RI, SI, or associated RI-SI infarctions was conducted. METHODS: All consecutive cases diagnosed by CT imaging, between January 2013 and October 2016, were included. The exclusion criteria were causes of infarction that did not require additional investigations. RESULTS: A total of 161 patients were selected for analysis: 34 patients with RI, 104 patients with SI and 23 patients with both RI-SI. Mean ± SD age of patients was 63.2 ± 16.6 years; 59.6% were male. Only 5/161 (3.1%) were healthy prior to the event. The main symptoms were diffuse abdominal pain (26.4%), followed by nausea/vomiting (18.3%) and fever (16.4%).The causes of RI or SI varied significantly within the three groups. Hypercoagulable state was associated with SI, and embolic disease and arterial injury were associated with RI. Extensive (i.e.>2/3 of organ volume) (OR 6.22, 95%CI 2.0119.22) and bilateral infarctions (OR 15.05, 95%CI 1.79-126.78) were significantly associated with hemodynamic shocks. The survival at 1 month follow-up did not significantly differ between the three groups. CONCLUSION: Acute RI and SI are heterogenous entities in regards to their clinical presentation, etiology, associated venous or arterial thrombosis, but prognoses were not different at short term follow-up.
Subject(s)
Infarction/diagnostic imaging , Kidney/blood supply , Splenic Infarction/diagnostic imaging , Abdominal Pain/etiology , Acute Disease , Adult , Aged , Aged, 80 and over , Female , France , Humans , Infarction/diagnosis , Infarction/pathology , Kidney/diagnostic imaging , Male , Middle Aged , Retrospective Studies , Splenic Infarction/etiology , Thrombophilia/complications , Thrombosis/complications , Tomography, X-Ray ComputedABSTRACT
The aim of this study was to determine, first, the effect of sex and age on the results of plasma fibronectin (Fn), and also the possible influence of the gestational age. The plasma Fn concentrations are higher in men than in women only in a range of 15-29 years old. The age dependence is very strong on plasma Fn levels; it practically double during life. The Fn concentrations according to age increase exponentially in men, linearly in women. The influence of gestational age is effective when it is less than thirty one weeks. Then, the Fn concentrations are significantly lower than in healthy newborn infants.
