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Surg Obes Relat Dis ; 13(2): 162-168, 2017 Feb.
Article in English | MEDLINE | ID: mdl-28341056

ABSTRACT

BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for obesity and associated metabolic complications. Obesity and type 2 diabetes are associated with increased oxidative stress. Previous studies have examined changes in plasma oxidative stress after laparoscopic Roux-en-Y gastric bypass, but there is limited evidence of the effects of LSG. OBJECTIVES: To examine the effects of LSG on plasma thiobarbituric acid reactive substances (TBARS) and total antioxidant status (TAOS) at 1 and 6 months after LSG in patients with obesity and impaired glucose regulation. SETTING: University hospital, United Kingdom. METHODS: Twenty-two participants with impaired glucose homeostasis undergoing LSG (body mass index 50.1 kg/m2, glycated hemoglobin 53 mmol/mol) were studied. Measurements of fasting and 120-minute TBARS and TAOS were performed during an oral glucose tolerance test preoperatively and postoperatively. RESULTS: Compared with preoperative levels, significant decreases were seen 6 months postoperatively in fasting TBARS (61.0±17.9 versus 39.4±13.8 ng/mL, P = .04) and 120-minute TBARS (76.0±29.5 versus 46.5±16.3 ng/mL, P = .02). No significant changes were observed in plasma TAOS. No significant association was observed between changes in TBARS and other clinical or biochemical measures. CONCLUSION: We observed a significant reduction in TBARS, a global measure of lipid peroxidation 6 months after LSG in participants with obesity and impaired glucose regulation.


Subject(s)
Antioxidants/metabolism , Blood Glucose/metabolism , Gastrectomy/methods , Laparoscopy/methods , Oxidative Stress/physiology , Thiobarbiturates/metabolism , Adult , Biomarkers/metabolism , Diabetes Mellitus, Type 2/blood , Diabetes Mellitus, Type 2/surgery , Female , Glucose Intolerance/blood , Glucose Intolerance/surgery , Glucose Tolerance Test , Homeostasis , Humans , Male , Middle Aged , Obesity, Morbid/surgery , Postoperative Care , Prospective Studies , Young Adult
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