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Bioorg Med Chem Lett ; 10(8): 715-7, 2000 Apr 17.
Article in English | MEDLINE | ID: mdl-10782671

ABSTRACT

4-Thiazolidinones were synthesized and evaluated for their ability to inhibit the bacterial enzyme MurB. Selected 4-thiazolidinones displayed activity against the enzyme in vitro. This activity, coupled with the design principles of the thiazolidinones, supports the postulate that 4-thiazolidinones may be recognized as diphosphate mimics by a biological selector.


Subject(s)
Bacteria/enzymology , Carbohydrate Dehydrogenases/antagonists & inhibitors , Enzyme Inhibitors/pharmacology , Thiazoles/pharmacology
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