ABSTRACT
BACKGROUND: Bloating is a fastidious symptom reported by many patients who also have other gastrointestinal functional disorders. Bloating is more common in women, and it is often associated with meals and improves or disappears overnight. No specific treatments are to date available for this disturbing symptom. AIMS: to evaluate the effects of an oral enterovaccine (Colifagina) on bloating and other abdominal symptoms in patients with prevalent complaints of functional bloating. PATIENTS AND METHODS: One hundred and forty-eight patients with functional bloating according to Rome III criteria were recruited. Questionnaires and a VAS scale on their symptoms were administered at baseline and after four weeks of therapy with Colifagina. RESULTS: After treatment, a significant amelioration of bloating (p < 0.0001), abdominal pain (p < 0.0001) and flatus (p < 0.0001) was observed; nausea and vomiting scores were not significantly different at the end of the treatment. Subjective wellbeing was also generally improved (p < 0.001) in treated patients. CONCLUSION: Treatment with an enterovaccine may help improve symptoms in patients with functional bloating.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Bacteria/immunology , Bacterial Vaccines/therapeutic use , Flatulence/therapy , Probiotics/therapeutic use , Adolescent , Adult , Animals , Disease Models, Animal , Female , Flatulence/etiology , Humans , Interviews as Topic , Male , Mice , Middle Aged , Nausea/therapy , Pain Measurement , Statistics, Nonparametric , Surveys and Questionnaires , Treatment Outcome , Vomiting/therapyABSTRACT
Background: bloating is a fastidious symptom reported bymany patients who also have other gastrointestinal functional disorders.Bloating is more common in women, and it is often associatedwith meals and improves or disappears overnight. No specifictreatments are to date available for this disturbing symptom.Aims: to evaluate the effects of an oral enterovaccine (Colifagina®) on bloating and other abdominal symptoms in patients withprevalent complaints of functional bloating.Patients and methods: one hundred and forty-eight patientswith functional bloating according to Rome III criteria were recruited.Questionnaires and a VAS scale on their symptoms wereadministered at baseline and after four weeks of therapy with Colifagina®.Results: after treatment, a significant amelioration of bloating(p < 0.0001), abdominal pain (p < 0.0001) and flatus (p <0.0001) was observed; nausea and vomiting scores were not significantlydifferent at the end of the treatment. Subjective wellbeingwas also generally improved (p < 0.001) in treated patients.Conclusion: treatment with an enterovaccine may help improvesymptoms in patients with functional bloating(AU)
Subject(s)
Humans , Animals , Male , Female , Adolescent , Adult , Mice , Adjuvants, Immunologic/therapeutic use , Bacterial Vaccines/therapeutic use , Flatulence/etiology , Flatulence/therapy , Probiotics/therapeutic use , Vomiting/therapy , Disease Models, Animal , Interviews as Topic , Nausea/therapy , /methods , Surveys and Questionnaires , Statistics, Nonparametric , Treatment OutcomeSubject(s)
Botulinum Toxins/administration & dosage , Chagas Disease/diagnosis , Chagas Disease/drug therapy , Travel , Trypanosoma cruzi/isolation & purification , Adult , Allopurinol/therapeutic use , Animals , Deglutition Disorders/diagnosis , Deglutition Disorders/etiology , Esophagoscopy/methods , Female , Follow-Up Studies , Gastroscopy/methods , Humans , Manometry , Risk Assessment , Treatment OutcomeABSTRACT
BACKGROUND: Patients with gastro-oesophageal reflux disease may complain of epigastric pain, bloating, early satiety, epigastric fullness, epigastric burning, nausea and vomiting. AIMS: To evaluate the symptoms in response to gastric distension and its relationship to a therapeutic course in patients with gastro-oesophageal reflux disease using the water load test, compared to healthy controls. METHODS: Thirty gastro-oesophageal reflux disease patients with grade A oesophagitis (studied before and after 4 weeks of therapy with esomeprazole, 40 mg per day) and 15 patients with reflux-related symptoms demonstrated at wireless pH monitoring (non-erosive reflux disease) were compared to 30 healthy volunteers. RESULTS: Patients with grade A oesophagitis and with reflux-related symptoms ingested significantly lower water volumes than did controls, before onset of fullness, without statistically significant difference between erosive or non-erosive gastro-oesophageal reflux disease; this variable improved in patients after treatment. Nausea scores were higher basally in patients, pre- and post-therapy, and improved after therapy. Thirty-minute fullness and bloating scores improved after therapy in all gastro-oesophageal reflux disease patients compared to controls and pre-therapy. In all pre-treatment patients, a significant correlation was found only with epigastric fullness; after treatment, there was no significant relationship between the water load and the symptom scores. CONCLUSIONS: In patients with reflux-related symptoms, with or without grade A oesophagitis, the water load test is frequently abnormal, suggesting an altered gastric function. This could explain the incomplete resolution of symptoms after treatment in some patients, and should lead to additional studies aimed at exploring gastric function in gastro-oesophageal reflux disease patients.
Subject(s)
Dyspepsia/drug therapy , Enzyme Inhibitors/therapeutic use , Esomeprazole/therapeutic use , Esophagitis, Peptic/drug therapy , Gastroesophageal Reflux/drug therapy , Water , Adult , Drinking/physiology , Dyspepsia/etiology , Esophagitis, Peptic/complications , Esophagitis, Peptic/diagnosis , Female , Gastroesophageal Reflux/complications , Gastroesophageal Reflux/diagnosis , Humans , Male , Middle Aged , Treatment OutcomeABSTRACT
The Authors report their experience of major and minor complications in carotid surgery. They analyse the causes and emphasize that a thorough preoperative study and a quick surgical technique are very important in reducing the rate of complications in this essentially preventive form of surgery.
Subject(s)
Carotid Arteries/surgery , Aged , Aged, 80 and over , Carotid Artery Diseases/surgery , Carotid Artery, Internal/surgery , Constriction, Pathologic , Female , Humans , Male , Middle Aged , Postoperative ComplicationsABSTRACT
Two cases of splenectomy are reported following the diagnosis of a rare pathology of the spleen in the form of two primary, non-parasitic and non traumatic spleen cysts. One was located on an epithelial wall and the other on an endothelial wall.
Subject(s)
Cysts/surgery , Lymphangioma/surgery , Splenic Diseases/surgery , Splenic Neoplasms/surgery , Adult , Cysts/diagnosis , Diagnosis, Differential , Female , Humans , Lymphangioma/diagnosis , Male , Splenectomy , Splenic Diseases/diagnosis , Splenic Neoplasms/diagnosisABSTRACT
The paper describes 20 cases of early gastric cancer diagnosed by endoscopy and multiple biopsies, combined with x-ray tests using a double contrast medium, with the aim of reducing the number of false negatives. Surgery was modified according to the site and macroscopic characteristics of the neoplastic lesion (type 1, 2a, 2b: total gastrectomy + extended lymphadenectomy; type 2c and 3: gastric resection, except for different indications according to the site). In line with data reported by other Authors, the five-year survival rate was 90%.
Subject(s)
Adenocarcinoma, Mucinous/surgery , Polyps/surgery , Precancerous Conditions/surgery , Stomach Neoplasms/surgery , Female , Follow-Up Studies , Gastrectomy , Humans , Lymph Node Excision , Male , Middle Aged , Stomach Neoplasms/mortality , Time FactorsSubject(s)
Duodenum/pathology , Whipple Disease/diagnosis , Biopsy , Duodenoscopy , Humans , Male , Middle Aged , Whipple Disease/pathologySubject(s)
Precancerous Conditions , Stomach Neoplasms , Adult , Aged , Chronic Disease , Duodenal Ulcer/complications , Duodenitis/complications , Female , Gastritis, Atrophic/complications , Humans , Male , Middle Aged , Polyps/complications , Risk , Stomach Neoplasms/etiology , Stomach Ulcer/complicationsSubject(s)
Clindamycin/adverse effects , Enterocolitis, Pseudomembranous/etiology , Lincomycin/adverse effects , Administration, Oral , Adult , Clindamycin/administration & dosage , Drug Therapy, Combination , Enterocolitis, Pseudomembranous/therapy , Humans , Infusions, Parenteral , Lincomycin/administration & dosage , Male , Oxytetracycline/administration & dosageABSTRACT
A case of angiosarcoma of the spleen is examined. In a review of reports in the literature of primary malignant tumours of the spleen, the extreme variety of this neoplasia and the lack of any precise classification are underlined.
Subject(s)
Hemangiosarcoma/pathology , Splenic Neoplasms/pathology , Diabetes Mellitus, Type 1/complications , Humans , Male , Middle Aged , Obesity/complications , Splenic Neoplasms/complications , UltrasonographyABSTRACT
105 duodenal ulcer patients were examined over a two-year period. Apart from anamnesis, endoscopy and radiology, a personal treatment protocol was used to assess the indications for medical or surgical treatment. Endoscopy undeniably plays a central role in identifying the characteristics of the ulcer and its complications and will indicate medical treatment for the majority of duodenal ulcers though it also serves to confirm or modify the indication for surgery.
