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1.
J Gen Intern Med ; 36(7): 1921-1927, 2021 07.
Article in English | MEDLINE | ID: mdl-33507479

ABSTRACT

BACKGROUND: Patient knowledge about the purpose of medications is crucial to ensure safe and correct use, so it is an important index of adherence in patients with chronic illness. OBJECTIVE: We examined how health literacy and its components (processing capacity and knowledge about illness) influence memory for medication purposes. DESIGN: We conducted a cross-sectional study to examine memory for medication purposes in relation to health literacy, processing capacity, and illness knowledge among patients with diabetes in outpatient clinics. PARTICIPANTS: Six hundred seventy-four adults who were diagnosed with type II diabetes mellitus, age 40 years or older, taking 5 or more current medications, native speakers of English, and with glycosylated hemoglobin (HbA1c) of 6.0 or more, were recruited to the study. MAIN MEASURES: We included measures of processing capacity, illness knowledge, health literacy, and actionable memory for medication taking (memory for medication purpose). KEY RESULTS: Results suggested an association between health literacy and both processing capacity and health knowledge, with some evidence that knowledge can compensate for limited processing capacity in order to maintain health literacy. Furthermore, health literacy was associated with memory for medication purposes, with processing capacity and health knowledge partly mediating this association. This pattern of results supports the process-knowledge model of health literacy. CONCLUSIONS: Our findings establish the role of health literacy in medication taking, in relation to broader cognitive abilities and knowledge. Implications for improving the learning of medication purpose among diverse older adults with chronic illness are discussed. TRIAL REGISTRATION: NIH trial registry number: NCT01296633.


Subject(s)
Diabetes Mellitus, Type 2 , Health Literacy , Adult , Aged , Cross-Sectional Studies , Diabetes Mellitus, Type 2/drug therapy , Health Knowledge, Attitudes, Practice , Humans , Medication Adherence
2.
Gerontologist ; 58(4): 686-695, 2018 07 13.
Article in English | MEDLINE | ID: mdl-28329840

ABSTRACT

Purpose of the Study: Older adults' self-care often depends on understanding and utilizing health information. Inadequate health literacy among older adults poses a barrier to self-care because it hampers comprehension of this information, particularly when the information is not well-designed. Our goal was to improve comprehension of online health information among older adults with hypertension who varied in health literacy abilities. Design and Methods: We identified passages about hypertension self-care from credible websites (typical passages). We used a multi-faceted approach to redesign these passages, revising their content, language, organization and format (revised passages). Older participants read both versions of the passages at their own pace. After each passage, they summarized the passage and then answered questions about the passage. Results: Participants better remembered the revised than the typical passages, summarizing the passages more accurately and uptaking information more efficiently (less reading time needed per unit of information remembered). The benefits for reading efficiency were greater for older adults with more health knowledge, suggesting knowledge facilitated comprehension of information in the revised passages. Implications: A systematic, multi-faceted approach to designing health documents can promote online learning among older adults with diverse health literacy abilities.


Subject(s)
Consumer Health Information , Documentation/standards , Education, Distance/methods , Health Literacy , Patient Education as Topic/methods , Aged , Consumer Health Information/methods , Consumer Health Information/standards , Female , Health Knowledge, Attitudes, Practice , Humans , Male , Quality Improvement , Self Care/psychology , United States
3.
AMIA Annu Symp Proc ; 2018: 185-194, 2018.
Article in English | MEDLINE | ID: mdl-30815056

ABSTRACT

In an effort to guide the development of a computer agent (CA)-based adviser system that presents patient-centered language to older adults (e.g., medication instructions in portal environments or smartphone apps), we evaluated 360 older and younger adults' responses to medication information delivered by a set of CAs. We assessed patient memory for medication information, their affective responses to the information, their perception of the CA's teaching effectiveness and expressiveness, and their perceived level of similarity with each CA. Each participant saw CAs varying in appearance and levels of realism (Photo-realistic vs Cartoon vs Emoji, as control condition). To investigate the impact of affective cues on patients, we varied CA message framing, with effects described either as gains of taking or losses of not taking the medication. Our results corroborate the idea that CAs can produce a significant effect on older adults' learning in part by engendering social responses.


Subject(s)
Communication , Medication Therapy Management , Software , Translating , Adult , Age Factors , Aged , Audiovisual Aids , Female , Health Literacy , Humans , Male , Memory , Middle Aged , Unified Medical Language System
4.
Gerontologist ; 57(2): 261-268, 2017 04 01.
Article in English | MEDLINE | ID: mdl-26209450

ABSTRACT

Purpose of the Study: Health literacy is associated with health outcomes presumably because it influences the understanding of information needed for self-care. However, little is known about the language comprehension mechanisms that underpin health literacy. Design and Methods: We explored the relationship between a commonly used measure of health literacy (Short Test of Functional Health Literacy in Adults [STOFHLA]) and comprehension of health information among 145 older adults. Results: Results showed that performance on the STOFHLA was associated with recall of health information. Consistent with the Process-Knowledge Model of Health Literacy, mediation analysis showed that both processing capacity and knowledge mediated the association between health literacy and recall of health information. In addition, knowledge moderated the effects of processing capacity limits, such that processing capacity was less likely to be associated with recall for older adults with higher levels of knowledge. Implications: These findings suggest that knowledge contributes to health literacy and can compensate for deficits in processing capacity to support comprehension of health information among older adults. The implications of these findings for improving patient education materials for older adults with inadequate health literacy are discussed.


Subject(s)
Cognition , Health Knowledge, Attitudes, Practice , Health Literacy , Hypertension/therapy , Mental Recall , Self Care , Aged , Comprehension , Female , Humans , Male , Middle Aged
5.
J Diabetes Res ; 2016: 2129838, 2016.
Article in English | MEDLINE | ID: mdl-27699179

ABSTRACT

Among patients with various levels of health literacy, the effects of collaborative, patient-provider, medication-planning tools on outcomes relevant to self-management are uncertain. Objective. Among adult patients with type II diabetes mellitus, we tested the effectiveness of a medication-planning tool (Medtable™) implemented via an electronic medical record to improve patients' medication knowledge, adherence, and glycemic control compared to usual care. Design. A multicenter, randomized controlled trial in outpatient primary care clinics. 674 patients received either the Medtable tool or usual care and were followed up for up to 12 months. Results. Patients who received Medtable had greater knowledge about indications for medications in their regimens and were more satisfied with the information about their medications. Patients' knowledge of drug indication improved with Medtable regardless of their literacy status. However, Medtable did not improve patients' demonstrated medication use, regimen adherence, or glycemic control (HbA1c). Conclusion. The Medtable tool supported provider/patient collaboration related to medication use, as reflected in patient satisfaction with communication, but had limited impact on patient medication knowledge, adherence, and HbA1c outcomes. This trial is registered with ClinicalTrials.gov NCT01296633.


Subject(s)
Diabetes Mellitus, Type 2/drug therapy , Hypoglycemic Agents/therapeutic use , Patient Participation , Patient Satisfaction , Self Care , Adult , Blood Glucose , Electronic Health Records , Female , Humans , Male , Medication Adherence , Middle Aged
6.
Memory ; 23(4): 577-89, 2015.
Article in English | MEDLINE | ID: mdl-24787361

ABSTRACT

While there is evidence that knowledge influences understanding of health information, less is known about the processing mechanisms underlying this effect and its impact on memory. We used the moving window paradigm to examine how older adults varying in domain-general crystallised ability (verbal ability) and health knowledge allocate attention to understand health and domain-general texts. Participants (n = 107, age: 60-88 years) read and recalled single sentences about hypertension and about non-health topics. Mixed-effects modelling of word-by-word reading times suggested that domain-general crystallised ability increased conceptual integration regardless of text domain, while health knowledge selectively increased resource allocation to conceptual integration at clause boundaries in health texts. These patterns of attentional allocation were related to subsequent recall performance. Although older adults with lower levels of crystallised ability were less likely to engage in integrative processing, when they did, this strategy had a compensatory effect in improving recall. These findings suggest that semantic integration during reading is an important comprehension process that supports the construction of the memory representation and is engendered by knowledge. Implications of the findings for theories of text processing and memory as well as for designing patient education materials are discussed.


Subject(s)
Aging/psychology , Comprehension , Health Literacy , Memory , Aged , Aged, 80 and over , Attention , Female , Humans , Male , Mental Recall , Middle Aged , Reading
7.
Can J Gastroenterol Hepatol ; 28(1): 50-3, 2014 Jan.
Article in English | MEDLINE | ID: mdl-24212912

ABSTRACT

BACKGROUND: Endoscopic transmural necrosectomy (ETN) is emerging as a viable treatment option for walled-off pancreatic necrosis. This NOTES-type procedure is significantly less invasive than an extensive surgical debridement; however, published data regarding the success of ETN in treating pancreatic necrosis have varied. OBJECTIVE: To evaluate the published medical literature to determine the success of treating walled-off pancreatic necrosis with ETN. METHODS: Studies using ETN as a primary mode of therapy to treat organized pancreatic necrosis were selected. Success was defined as resolution of the necrotic cavity proven by radiology. Articles were searched in Medline, PubMed, Ovid journals, CINAH, old Medline, Medline nonindexed citations and the Cochrane controlled trials registry. The summary estimates were expressed as pooled proportions. First, the individual study proportions were transformed into a quantity using Freeman-Tukey variant of the arcsine square root transformed proportion. The pooled proportion was calculated as the back-transform of the weighted mean of the transformed proportions, using inverse arcsine variance weights for the fixed-effects model and DerSimonian-Laird weights for the random-effects model. Publication bias was calculated using the Begg-Mazumdar and Harbord bias estimators. RESULTS: The initial search identified 920 reference articles, of which 129 relevant articles were selected and reviewed. Data were extracted from eight studies (n=233) that met the inclusion criteria. Organization of pancreatic necrosis was determined by computed tomography scan in all of the studies. The mean time of ETN after onset of acute pancreatitis/abdominal pain was seven weeks. The weighted mean size of the necrotic cavity was 12.87 cm (95% CI 10.54 cm to 15.20 cm). The weighted mean number of endoscopic procedures needed to resolve the necrotic cavity was 4.09 (95% CI 2.31 to 5.87). Pooled proportion of successful resolution of pancreatic necrosis using ETN was 81.84% (95% CI 76.73% to 86.44%). The pooled proportion of recurrence in the form of necrotic cavity or pseudocyst after ETN was 10.88% (95% CI 7.27% to 15.11%). Complications were noted in 21.33% (95% CI 16.40% to 26.72%) of patients and included bleeding, sepsis and perforation. The weighted mean number of days in hospital after ETN was 32.85 days (95% CI 10.50 to 55.20 days). For pancreatic necrosis that did not resolve, surgery had to be performed in 12.98% (95% CI 9.05% to 17.51%) of patients. The fixed-effect model was used to report all of the pooled proportions. Estimates calculated using fixed- and random-effects models were similar. Test of heterogeneity yielded P>0.10, indicating that the studies could be combined. The publication bias calculated using Begg-Mazumdar bias indicator yielded a Kendall's tau b value of -0.07 (P=0.72) and the same using Harbord bias indicator gave a value of 0.33 (95% CI -1.35 to 2.01; P=0.60). Both of these indicators show that there was no publication bias. CONCLUSION: The present meta-analysis showed that ETN is safe and effective at treating patients with symptomatic walled-off necrosis. ETN offers the advantage of minimally invasive endoscopic treatment without transabdominal surgery; however, better techniques and equipment are still needed to improve procedural efficiency. Decisions to perform ETN should be made by advanced endoscopists in collaboration with a multidisciplinary team with the facilities and personnel to manage these complex patients.


Subject(s)
Cholangiopancreatography, Endoscopic Retrograde , Debridement , Natural Orifice Endoscopic Surgery , Pancreatic Diseases/surgery , Cholangiopancreatography, Endoscopic Retrograde/methods , Clinical Trials as Topic , Debridement/methods , Endosonography , Evidence-Based Medicine , Humans , Interdisciplinary Communication , Natural Orifice Endoscopic Surgery/methods , Necrosis , Pancreatectomy/methods , Pancreatic Diseases/diagnostic imaging , Pancreatic Diseases/pathology , Pancreatitis, Acute Necrotizing/surgery , Reproducibility of Results , Treatment Outcome
8.
Stat Med ; 32(5): 884-97, 2013 Feb 28.
Article in English | MEDLINE | ID: mdl-22961832

ABSTRACT

The debate over whether certain antihypertensive medications have benefits beyond what would be expected from their blood pressure lowering spurred the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, which randomized 42,418 participants to chlorthalidone (15,255), amlodipine (9048), lisinopril (9054), or doxazosin (9061). We compared chlorthalidone, the active control, with each of the other three agents with respect to the primary outcome, fatal coronary heart disease or nonfatal myocardial infarction, and several other clinical endpoints. The arms were similar with respect to the primary endpoint, although some differences were found for other endpoints, most notably heart failure. Although the desire was to achieve similar blood pressure reductions in the four arms, we found some systolic blood pressure and diastolic blood pressure differences. A natural question is to what degree can observed treatment group differences in cardiovascular outcomes be attributed to these blood pressure differences. The purpose of this paper was to delineate the problems inherent in attempting to answer this question, and to present analyses intended to overcome these problems.


Subject(s)
Antihypertensive Agents/therapeutic use , Biostatistics/methods , Blood Pressure/drug effects , Cardiovascular Diseases/prevention & control , Amlodipine/therapeutic use , Chlorthalidone/therapeutic use , Coronary Disease/prevention & control , Endpoint Determination/statistics & numerical data , Heart Failure/prevention & control , Humans , Hypertension/drug therapy , Hypertension/physiopathology , Lisinopril/therapeutic use , Myocardial Infarction/prevention & control , Randomized Controlled Trials as Topic/statistics & numerical data , Regression Analysis , Treatment Outcome
9.
Am Heart J ; 164(6): 925-31.e2, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23194494

ABSTRACT

BACKGROUND/AIMS: The value of the Framingham equation in predicting cardiovascular risk in African Americans and patients with chronic kidney disease (CKD) is unclear. The purpose of the study was to evaluate whether the addition of CKD and race to the Framingham equation improves risk stratification in hypertensive patients. METHODS: Participants in the ALLHAT were studied. Those randomized to doxazosin, older than 74 years, and those with a history of coronary heart disease were excluded. Two risk stratification models were developed using Cox proportional hazards models in a two-thirds developmental sample. The first model included the traditional Framingham risk factors. The second model included the traditional risk factors plus CKD, defined by estimated glomerular filtration rate categories, and stratification by race (black vs non-black). The primary outcome was a composite of fatal coronary heart disease, nonfatal myocardial infarction, coronary revascularization, and hospitalized angina. RESULTS: There were a total of 19,811 eligible subjects. In the validation cohort, there was no difference in C-statistics between the Framingham equation and the ALLHAT model including CKD and race. This was consistent across subgroups by race and sex and among those with CKD. One exception was among Non-Black women where the C-statistic was higher for the Framingham equation (0.68 vs 0.65, P = .02). In addition, net reclassification improvement was not significant for any subgroup based on race and sex, ranging from -5.5% to 4.4%. CONCLUSION: The addition of CKD status and stratification by race does not improve risk prediction in high-risk hypertensive patients.


Subject(s)
Coronary Disease/ethnology , Hypertension/ethnology , Renal Insufficiency, Chronic/ethnology , Angina Pectoris/ethnology , Black People , Cohort Studies , Female , Humans , Male , Middle Aged , Myocardial Infarction/ethnology , Myocardial Revascularization , Proportional Hazards Models , Racial Groups , Risk Assessment
10.
Contemp Clin Trials ; 33(5): 1023-32, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22664648

ABSTRACT

Patients with type II diabetes often struggle with self-care, including adhering to complex medication regimens and managing their blood glucose levels. Medication nonadherence in this population reflects many factors, including a gap between the demands of taking medication and the limited literacy and cognitive resources that many patients bring to this task. This gap is exacerbated by a lack of health system support, such as inadequate patient-provider collaboration. The goal of our project is to improve self-management of medications and related health outcomes by providing system support. The Medtable™ is an Electronic Medical Record (EMR)-integrated tool designed to support patient-provider collaboration needed for medication management. It helps providers and patients work together to create effective medication schedules that are easy to implement. We describe the development and initial evaluation of the tool, as well as the process of integrating it with an EMR system in general internal medicine clinics. A planned evaluation study will investigate whether an intervention centered on the Medtable™ improves medication knowledge, adherence, and health outcomes relative to a usual care control condition among type II diabetic patients struggling to manage multiple medications.


Subject(s)
Cooperative Behavior , Diabetes Mellitus, Type 2/drug therapy , Electronic Health Records , Hypoglycemic Agents/therapeutic use , Medication Adherence/statistics & numerical data , Health Knowledge, Attitudes, Practice , Health Literacy , Humans , Hypoglycemic Agents/administration & dosage , Multicenter Studies as Topic/methods , Nurse-Patient Relations , Nurses , Randomized Controlled Trials as Topic/methods , Self Care/methods
11.
Circulation ; 124(17): 1811-8, 2011 Oct 25.
Article in English | MEDLINE | ID: mdl-21969009

ABSTRACT

BACKGROUND: In the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), a randomized, double-blind, practice-based, active-control, comparative effectiveness trial in high-risk hypertensive participants, risk of new-onset heart failure (HF) was higher in the amlodipine (2.5-10 mg/d) and lisinopril (10-40 mg/d) arms compared with the chlorthalidone (12.5-25 mg/d) arm. Similar to other studies, mortality rates following new-onset HF were very high (≥50% at 5 years), and were similar across randomized treatment arms. After the randomized phase of the trial ended in 2002, outcomes were determined from administrative databases. METHODS AND RESULTS: With the use of national databases, posttrial follow-up mortality through 2006 was obtained on participants who developed new-onset HF during the randomized (in-trial) phase of ALLHAT. Mean follow-up for the entire period was 8.9 years. Of 1761 participants with incident HF in-trial, 1348 died. Post-HF all-cause mortality was similar across treatment groups, with adjusted hazard ratios (95% confidence intervals) of 0.95 (0.81-1.12) and 1.05 (0.89-1.25), respectively, for amlodipine and lisinopril compared with chlorthalidone, and 10-year adjusted rates of 86%, 87%, and 83%, respectively. All-cause mortality rates were also similar among those with reduced ejection fractions (84%) and preserved ejection fractions (81%), with no significant differences by randomized treatment arm. CONCLUSIONS: Once HF develops, risk of death is high and consistent across randomized treatment groups. Measures to prevent the development of HF, especially blood pressure control, must be a priority if mortality associated with the development of HF is to be addressed. Clinical Trial Registration- http://www.clinicaltrials.gov. Unique identifier: NCT00000542.


Subject(s)
Antihypertensive Agents/therapeutic use , Heart Failure/drug therapy , Hypolipidemic Agents/therapeutic use , Myocardial Ischemia/prevention & control , Aged , Double-Blind Method , Female , Follow-Up Studies , Heart Failure/mortality , Heart Failure/physiopathology , Humans , Male , Middle Aged , Myocardial Ischemia/mortality , Myocardial Ischemia/physiopathology , Time Factors , Treatment Outcome
12.
J Health Commun ; 16 Suppl 3: 222-41, 2011.
Article in English | MEDLINE | ID: mdl-21951254

ABSTRACT

We investigated the effects of domain-general processing capacity (fluid ability such as working memory), domain-general knowledge (crystallized ability such as vocabulary), and domain-specific health knowledge for two of the most commonly used measures of health literacy (S-TOFHLA and REALM). One hundred forty six community-dwelling older adults participated; 103 had been diagnosed with hypertension. The results showed that older adults who had higher levels of processing capacity or knowledge (domain-general or health) performed better on both of the health literacy measures. Processing capacity interacted with knowledge: Processing capacity had a lower level of association with health literacy for participants with more knowledge than for those with lower levels of knowledge, suggesting that knowledge may offset the effects of processing capacity limitations on health literacy. Furthermore, performance on the two health literacy measures appeared to reflect a different weighting for the three types of abilities. S-TOFHLA performance reflected processing capacity as well as general knowledge, whereas performance on the REALM depended more on general and health knowledge than on processing capacity. The findings support a process-knowledge model of health literacy among older adults, and have implications for selecting health literacy measures in various health care contexts.


Subject(s)
Educational Measurement/methods , Health Knowledge, Attitudes, Practice , Health Literacy , Mental Processes , Models, Psychological , Aged , Aged, 80 and over , Female , Humans , Hypertension/psychology , Knowledge , Male , Memory, Short-Term , Middle Aged , Vocabulary
13.
J Clin Hypertens (Greenwich) ; 11(9): 466-74, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19751458

ABSTRACT

J Clin Hypertens (Greenwich). 2009;11:466-474. (c)2009 Wiley Periodicals, Inc.Lower heart failure (HF) rates in individuals taking chlorthalidone vs amlodipine, lisinopril, or doxazosin were unanticipated in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). HF differences appeared early, leading to questions about the possible influence of pre-enrollment antihypertensive drugs. A post hoc study evaluated hospitalized HF events. During year 1479 individuals had HF, with pre-entry antihypertensive medication data obtained on 301 patients (63%). Case-only analysis examined interactive effects (interaction odds ratio [OR, ratio of ORs]) of previous medication and ALLHAT treatment on HF outcomes, eg, did treatment effect differ by pre-entry antihypertensive class? Among cases, 39%, 37%, 17%, and 47% were taking pre-entry diuretics, angiotensin-converting enzyme inhibitors, beta-blockers, and calcium channel blockers, respectively. Interaction OR for year 1 HF for amlodipine vs chlorthalidone for patients taking vs not taking diuretics pre-entry was 1.08 (95% confidence interval [CI], 0.53-2.21; P=.83); for lisinopril vs chlorthalidone, 1.33 (95% CI, 0.65-2.74; P=.44); and for doxazosin vs chlorthalidone, 1.13 (95% CI, 0.57-2.25; P=.73). Controlling for other pre-entry antihypertensives yielded similar results. There was no significant evidence that pre-entry drug type explained observed hospitalized HF differences by ALLHAT treatment.


Subject(s)
Adrenergic alpha-Antagonists/therapeutic use , Antihypertensive Agents/therapeutic use , Doxazosin/therapeutic use , Heart Failure/prevention & control , Hypertension/drug therapy , Treatment Outcome , Aged , Confidence Intervals , Double-Blind Method , Female , Heart Failure/etiology , Heart Failure/pathology , Humans , Hypertension/complications , Male , Multivariate Analysis , Odds Ratio , Risk , Risk Factors
14.
J Hosp Med ; 4(6): 356-63, 2009 Jul.
Article in English | MEDLINE | ID: mdl-19621342

ABSTRACT

BACKGROUND: Hospital discharge software potentially improves communication and clinical outcomes. OBJECTIVE: To measure patient and physician perceptions after discharge with computerized physician order entry (CPOE) software. DESIGN: Cluster randomized controlled trial. SETTING: Tertiary care, teaching hospital in central Illinois. PATIENTS: A total of 631 inpatients discharged to home with high risk for readmission. INTERVENTION: A total of 70 internal medicine hospital physicians randomly assigned (allocation concealed) to discharge software vs. usual care, handwritten discharge. MEASUREMENTS: Discharge perceptions from patients, outpatient primary care physicians, and hospital physicians. RESULTS: One week after discharge, 92.4% (583/631) of patients answered interviews. For 78.6% (496/631) of patients, their outpatient physicians returned questionnaires 19 days (median) postdischarge. Generalized estimating equations gave intervention variable coefficients with 95% confidence intervals (CIs). When comparing patients assigned to discharge software vs. usual care, patient mean (standard deviation [SD]) scores for discharge preparedness were higher (17.7 [4.1] vs. 17.2 [4.0]; coefficient = 0.147; 95% CI = 0.005-0.289; P = 0.042), patient scores for satisfaction with medication information were unchanged (12.3 [4.8] vs. 12.1 [4.6]; coefficient = -0.212; 95% CI = -0.937-0.513; P = 0.567), and their outpatient physicians scored higher quality discharge (17.2 [3.8] vs. 16.5 [3.9]; coefficient = 0.133; 95% CI = 0.015-0.251; P = 0.027). Hospital physicians found mean effort to use discharge software was more difficult than the usual care (6.5 [1.9] vs. 7.9 [2.1]; P = 0.011). CONCLUSIONS: Discharge software with CPOE caused small improvements in discharge perceptions by patients and their outpatient physicians. These small improvements might balance the difficulty perceived by hospital physicians who used discharge software.


Subject(s)
Attitude of Health Personnel , Medical Records Systems, Computerized , Patient Discharge , Patient Satisfaction , Physicians , Software , Adolescent , Adult , Aged , Aged, 80 and over , Cluster Analysis , Female , Humans , Male , Medical Records Systems, Computerized/trends , Middle Aged , Patient Discharge/trends , Patient Readmission , Physicians/trends , Software/trends , Young Adult
15.
Clin Trials ; 6(4): 329-43, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19587068

ABSTRACT

BACKGROUND: Conventional dissemination of clinical trial results has inconsistent impact on physician practices. A more comprehensive plan to influence determinants of prescribing practices is warranted. PURPOSE: To report the response from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial to the National Heart, Lung, and Blood Institute's requirement for dissemination and evaluation of trials with potential immediate public health applicability. METHODS: ALLHAT's dissemination plan had two-components: (1) a traditional approach of media coverage, scientific presentation, and publication; and (2) a theory-based approach targeting determinants of clinician behavior. Strategies included: (1) academic detailing, in which physicians approach colleagues regarding blood pressure management, (2) direct patient messages to stimulate communication with physicians regarding blood pressure control, (3) approaches to formulary systems to use educational and economic incentives for evidence-based prescription, and (4) direct professional organization appeals to clinicians. RESULTS: One hundred and forty-seven Investigator Educators reported 1698 presentations to 18,524 clinicians in 41 states and the District of Columbia. The pre- and post-test responses of 1709 clinicians in the face-to-face meetings indicated significant changes in expectations for positive patient outcomes and intention to prescribe diuretics. Information was mailed to 55 individuals representing 20 professional organizations and to eight formulary systems. Direct-to-patient messages were provided to 14 sites that host patient newsletters and Web sites such as health plans and insurance companies, 62 print mass media outlets, and 12 broadcast media sites. LIMITATIONS: It was not within the scope of the project to conduct a randomized trial of the impact of the dissemination. However, impact evaluation using quasi-experimental designs is ongoing. CONCLUSION: A large multi-method dissemination of clinical trial results is feasible. Planning for dissemination efforts, including evaluation research, should be considered as a part of the funding and design of the clinical trial and should begin early in trial planning.


Subject(s)
Clinical Trials as Topic/methods , Evidence-Based Medicine/methods , Program Development , Blood Pressure , Data Collection , Data Interpretation, Statistical , District of Columbia , Feasibility Studies , Humans , Program Evaluation , Surveys and Questionnaires
16.
J Hosp Med ; 4(7): E11-9, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19479782

ABSTRACT

BACKGROUND: One of the causes of postdischarge adverse events is poor discharge communication between hospital-based physicians, patients, and outpatient physicians. The value of hospital discharge software to improve communication and clinically relevant outcomes is unknown. OBJECTIVE: To measure effects of a discharge software application of computerized physician order entry (CPOE). DESIGN: Cluster randomized controlled trial. SETTING: Tertiary care, teaching hospital in central Illinois. PATIENTS: A total of 631 inpatients discharged to home with high risk for readmission. INTERVENTION: Seventy internal medicine hospital physicians were randomly assigned (allocation concealed) to discharge software versus usual care, handwritten discharge. MEASUREMENTS: Blinded assessment of patient readmission, emergency department visit, and postdischarge adverse event. RESULTS: A total of 590 (94%) patients provided 6-month follow-up data. Generalized estimating equations gave intervention variable coefficients with 95% confidence interval (CI). When comparing patients assigned to discharge software versus usual care, there was no difference in hospital readmission within 6 months (37.0% versus 37.8%; coefficient -0.005 [95% CI, -0.074 to 0.065]; P = 0.894), emergency department visit within 6 months (35.4% versus 40.6%; coefficient -0.052 [95% CI, -0.115 to 0.011]; P = 0.108), or adverse event within 1 month (7.3% versus 7.3%; coefficient 0.003 [95% CI; -0.037 to 0.043]; P = 0.884). CONCLUSIONS: Discharge software with CPOE did not affect readmissions, emergency department visits, or adverse events after discharge. Future studies should assess other endpoints such as patient perceptions or physician perceptions to see if discharge software has value.


Subject(s)
Continuity of Patient Care/organization & administration , Emergency Service, Hospital/statistics & numerical data , Medical Records Systems, Computerized , Patient Discharge/standards , Patient Readmission/statistics & numerical data , Software , Cluster Analysis , Female , Humans , Male , Patient Discharge/statistics & numerical data , Patient Satisfaction , Sample Size
17.
J Hosp Med ; 3(6): 446-54, 2008.
Article in English | MEDLINE | ID: mdl-19084894

ABSTRACT

BACKGROUND: Adverse events occur when patients transition from the hospital to outpatient care. For quality improvement and research purposes, clinicians need appropriate, reliable, and valid survey instruments to measure and improve the discharge processes. OBJECTIVE: The object was to describe psychometric properties of the Brief PREPARED (B-PREPARED) instrument to measure preparedness for hospital discharge from the patient's perspective. METHODS: The study was a prospective cohort of 460 patient or proxy telephone interviews following hospital discharge home. We administered the Satisfaction with Information about Medicines Scale and the PREPARED instrument 1 week after discharge. PREPARED measured patients' perceptions of quality and outcome of the discharge-planning processes. Four weeks after discharge, interviewers elicited emergency department visits. The main outcome was the B-PREPARED scale value: the sum of scores from 11 items. Internal consistency, construct, and predictive validity were assessed. RESULTS: : The mean B-PREPARED scale value was 17.3 +/- 4.2 (SD) with a range of 3 to 22. High scores reflected high preparedness. Principal component analysis identified 3 domains: self-care information, equipment/services, and confidence. The B-PREPARED had acceptable internal consistency (Cronbach's alpha 0.76) and construct validity. The B-PREPARED correlated with medication information satisfaction (P < 0.001). Higher median B-PREPARED scores appropriately discriminated patients with no worry about managing at home from worriers (P < 0.001) and predicted patients without emergency department visits after discharge from those who had visits (P = 0.011). CONCLUSIONS: The B-PREPARED scale measured patients' perceptions of their preparedness for hospital discharge home with acceptable internal consistency and construct and predictive validity. Brevity may potentiate use by patients and proxies. Clinicians and researchers may use B-PREPARED to evaluate discharge interventions.


Subject(s)
Patient Discharge/standards , Patient Education as Topic/standards , Weights and Measures/standards , Adult , Aged , Aged, 80 and over , Cohort Studies , Female , Follow-Up Studies , Health Care Surveys/methods , Health Care Surveys/standards , Humans , Male , Middle Aged , Patient Education as Topic/methods , Patient Satisfaction , Prospective Studies , Psychometrics
18.
J Hosp Med ; 3(6): 455-64, 2008.
Article in English | MEDLINE | ID: mdl-19084895

ABSTRACT

BACKGROUND: Adverse events occur when patients transition from hospital to outpatient care. For quality improvement and research purposes, clinicians need appropriate, reliable, and valid survey instruments to measure and improve discharge processes. OBJECTIVE: The objective of this study was to validate the Modified Physician-PREPARED scale to measure qualities of hospital discharge from the outpatient physician perspective. Descriptions include item development and psychometric properties. METHODS: The design was a postal survey of outpatient physicians/practitioners who followed 403 patients who were discharged from hospital to home. We mailed questionnaires 10 days after discharge. Questionnaire items assessed perceptions of quality and outcome of discharge planning and communication. Analysis yielded the Modified Physician-PREPARED scale value: the sum of scores from 8 items. Internal consistency and construct validity were assessed. RESULTS: Survey response rate was 76%. Mean Modified Physician-PREPARED scale value was 16.6 +/- 4.0 with range 8 to 24. High scores reflected high perceptions of discharge quality. Analysis identified 2 principal components: timeliness of communication, and adequacy of discharge plan/transmission. The scale had acceptable internal consistency (Cronbach's alpha 0.86) and construct validity. When considering the discharge planning and communication for a specific patient, outpatient primary care physicians reported higher scores when they were involved in the discharge planning (P < 0.001) and when they were aware of community support services (P = 0.002). CONCLUSIONS: The Modified Physician-PREPARED scale measured outpatient physician perceptions of quality of hospital discharge to home. Clinicians and researchers may find the scale useful to evaluate discharge processes.


Subject(s)
Attitude of Health Personnel , Patient Discharge/standards , Physicians/standards , Residence Characteristics , Surveys and Questionnaires/standards , Adult , Aged , Aged, 80 and over , Ambulatory Care/standards , Female , Humans , Male , Middle Aged , Physician-Patient Relations , Reproducibility of Results , Young Adult
19.
Inform Prim Care ; 14(2): 109-19, 2006.
Article in English | MEDLINE | ID: mdl-17059700

ABSTRACT

Discharge communication between inpatient and outpatient physicians is often an inefficient and error-prone process. Adverse events result from poor communication at the time of discharge. The objective of this study was to describe development of discharge software to overcome communication barriers. The secondary objective was to assess factors that influence the time to complete tasks with the software. Methods were a performance improvement model and database analysis of 336 discharges. Software design specifications included computerised physician order entry, immediate utility, minimal development and deployment costs, acceptability to physician-users, and satisfaction of primary care physicians, patients and pharmacists. Design features included simple 'just-in-time' prompts and point-of-care prescribing resources. The dependent variable for analysis was physician time to complete discharge prescriptions and instructions while using the software. General linear and mixed-effects regression models adjusted for physician effects and other predictors. Results revealed that physician factors significantly affected the time to complete a discharge while using the software. As the number of accesses (log-ins) and free text typing increased, then time to complete the computerised discharge increased. Patient-related factors that increased physician time were discharge diagnoses, prescriptions and length of stay. In conclusion, discharge software can help inpatient physicians transfer timely, complete and legible information to outpatient physicians, pharmacists and patients. Physician and patient factors influence the time to complete discharges using the software.


Subject(s)
Hospital Information Systems , Patient Discharge , Software Design , Adolescent , Adult , Aged , Aged, 80 and over , Continuity of Patient Care , Female , Hospitals, Teaching , Humans , Illinois , Male , Medical Records Systems, Computerized , Middle Aged
20.
Pharmacotherapy ; 25(10): 1296-302, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16185172

ABSTRACT

STUDY OBJECTIVES: To compare the incidence of hypoglycemic events in patients exposed to gatifloxacin or levofloxacin, and to measure the odds of experiencing a hypoglycemic event after receiving gatifloxacin versus levofloxacin while adjusting for confounders. DESIGN: Nested case-control study within a historical cohort. SETTING: A tertiary care, 730-bed, teaching hospital in central Illinois. PATIENTS: Seven thousand two hundred eighty-seven hospitalized patients who received gatifloxacin or levofloxacin therapy. MEASUREMENTS AND MAIN RESULTS: A total of 113 patients (case patients) had blood glucose levels below 51 mg/dl; 113 control patients, matched for age and sex, had no hypoglycemia. Matched conditional logistic regression models adjusted the odds of having hypoglycemia for significant covariates. The 12-month incidence of hypoglycemia was 11/1000 patients after levofloxacin administration and 21/1000 patients after gatifloxacin (absolute risk increase 10/1000 patients, 95% confidence interval [CI] 4-16/1000). Renal failure, sepsis syndrome, and concomitant hypoglycemic drug therapy significantly predicted hypoglycemia. After adjustment for significant predictors, the odds of having hypoglycemia were 2.81 (95% CI 1.02-7.70) times higher after gatifloxacin than levofloxacin therapy. CONCLUSION: Among inpatients, the incidence of hypoglycemic events is greater after treatment with gatifloxacin than levofloxacin. The odds of experiencing hypoglycemic events are greater with gatifloxacin even after adjusting for other hypoglycemia risk factors, such as concomitant hypoglycemic drugs, renal failure, and sepsis syndrome.


Subject(s)
Anti-Infective Agents/adverse effects , Fluoroquinolones/adverse effects , Hypoglycemia/chemically induced , Levofloxacin , Ofloxacin/adverse effects , Adult , Aged , Aged, 80 and over , Blood Glucose/analysis , Case-Control Studies , Female , Gatifloxacin , Humans , Male , Middle Aged , Risk Factors
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