ABSTRACT
BACKGROUND: Congenital Spitz nevus has been reported previously in the literature, but the histopathologic features have not been examined in detail. OBJECTIVE: To histologically examine and report on congenital Spitz nevus. METHOD: We examined 10 clinically submitted congenital melanocytic nevi that were histopathologically identified as congenital Spitz nevi and compared them to the characteristics seen in acquired Spitz nevus and superficial congenital melanocytic nevus. RESULTS: Of the 10 congenital Spitz nevi, 9 were compound and 1 was dermal. Two showed features of combined Spitz nevus (Spitz and blue). Six cases showed all 16 listed characteristics of acquired Spitz nevus, with two cases having 15 and two cases having 14 characteristics. Of the superficial congenital melanocytic nevus characteristics, all except three cases had all 12 attributes. The one dermal lesion had all the characteristics of the acquired Spitz nevus and all but one of the characteristics of the superficial congenital melanocytic nevus in regards to intradermal findings. CONCLUSIONS: Congenital Spitz nevi are true congenital lesions, with histopathologic features of both acquired Spitz nevus and superficial congenital melanocytic nevus.
Subject(s)
Nevus, Epithelioid and Spindle Cell/congenital , Nevus, Epithelioid and Spindle Cell/pathology , Skin Neoplasms/congenital , Skin Neoplasms/pathology , Adolescent , Adult , Biopsy, Needle , Child , Child, Preschool , Female , Humans , Immunohistochemistry , Male , Nevus, Epithelioid and Spindle Cell/surgery , Retrospective Studies , Sensitivity and Specificity , Skin Neoplasms/surgeryABSTRACT
Squamous cell carcinoma on sun-damaged skin is a malignant neoplasm that evolves from its inception as squamous cell carcinoma in situ, which is commonly referred to as an actinic keratosis. In this study, we reviewed 1011 squamous cell carcinomas on sun-damaged skin and found that nearly 100% of these lesions contained histopathologic changes consistent with squamous cell carcinoma in situ at the periphery or within the confines of the squamous cell carcinoma. These malignant changes began in single layer areas of the lower epidermis and evolved into the epidermis and dermis.
Subject(s)
Carcinoma in Situ/pathology , Carcinoma, Squamous Cell/pathology , Skin Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Female , Humans , Keratinocytes/pathology , Keratinocytes/radiation effects , Male , Middle Aged , Retrospective Studies , Skin/pathology , Skin/radiation effects , Sunlight/adverse effectsSubject(s)
Carcinoma, Squamous Cell/surgery , Nasal Mucosa , Nose Neoplasms/surgery , Aged , Female , Humans , Methods , Nasal Mucosa/surgeryABSTRACT
It is often desirable in laser spectroscopy and isotope separation to extract as much as possible of an atomic or molecular population that is distributed among a number of ground-state sublevels and low-lying metastable levels. We describe a form of coherent trapping that occurs when multiple resonant laser beams are used to couple the various ground states to a common upper level. This effect prevents the extraction of the entire population. We then study the effect with two dye lasers and an atomic beam and suggest possible ways to maximize the pumping efficiency.
