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Arch Virol ; 166(6): 1735-1739, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33761008

ABSTRACT

We developed a next-generation SARS-CoV-2 sequencing platform and obtained the first SARS-CoV-2 sequences from patients in Croatia at the beginning of the COVID-19 outbreak in the spring of 2020. Integrating the sequencing and the epidemiological data, we show that patients were infected with different SARS-CoV-2 variants belonging to different clades (mostly G and GH). This result confirms that there was widespread virus transmission early in 2020. Interestingly, we identified a unique mutation resulting in a V13I substitution in Nsp5A, the main viral protease, in a patient who had not received antiviral therapy.


Subject(s)
COVID-19/epidemiology , COVID-19/virology , Genetic Variation , SARS-CoV-2/genetics , Coronavirus 3C Proteases/chemistry , Croatia/epidemiology , Genome, Viral , Humans , Models, Molecular , Phylogeny , Protein Conformation , Whole Genome Sequencing
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