ABSTRACT
BACKGROUND: Warthin's tumor can be associated with various secondary changes that challenge both clinical and cytologic diagnosis. CASE: A 44-year-old man presented with a Warthin's tumor (WT) that was associated with multiple secondary changes. The right parotid mass was present and mostly asymptomatic for 6 years, but during the 7th year, there was pain and ipsilateral facial nerve dysfunction following abrupt increase in size of the mass. Fine needle aspiration (FNA) yielded murky, brown, viscous fluid, and the residual mass was also aspirated. Cytologic examination showed acute, chronic and granulomatous inflammation and rare squamous cells in a background of finely granular necrotic debris. Oncocytes were not identified. Histologic examination of the excised mass revealed a WT with extensive necrotizing granulomatous inflammation, with acute and chronic inflammation, fibrosis and squamous metaplasia. Microorganisms were not identified by culture or by special stains of the FNA cell block and histologic sections. CONCLUSION: The secondary changes observed in this case probably relate to spontaneous infarction of the WT. Awareness of the secondary changes that can occur in WT will help prevent misdiagnosis, which could result in inappropriate therapy, including unnecessary radical surgery.
Subject(s)
Adenolymphoma/pathology , Facial Paralysis/etiology , Parotid Neoplasms/pathology , Adenolymphoma/complications , Adult , Biopsy, Fine-Needle , Granuloma/pathology , Humans , Inflammation/pathology , Male , Necrosis/pathology , Parotid Neoplasms/complicationsABSTRACT
BACKGROUND: The fine-needle aspiration (FNA) diagnosis of proliferative breast lesion is an indeterminate category. The aim of this correlative study was to determine whether a subcategory of "proliferative breast lesion with atypia" was achievable and whether this subcategory has management utility. METHODS: Breast FNA cases from 2000 through 2005 diagnosed as proliferative breast lesion and proliferative breast lesion with atypia were retrieved. Both cytologic and surgical slides of these cases were reviewed blindly. A cytologic diagnosis of proliferative breast lesion (without atypia) or proliferative breast lesion with atypia was used if the findings of the proliferative breast lesion did not fit a more specific category. RESULTS: Of the 3934 breast FNAs performed on palpable breast masses from January 2000 to December 2005 at the LAC + USC Medical Center, 317 (8.1%) were diagnosed cytologically as proliferative breast lesion with atypia, without atypia or without mention of atypia. There was subsequent histopathology on 201 of these cases. After the cytologic smears were reviewed, 29 cases were excluded from this study. Of the 172 remaining cases, 21 (12.2%) were found to be malignant and the remaining 151 (87.8%) were found to be benign on histology. Of the malignant cases, 90% had an FNA diagnosis of proliferative breast lesion with atypia; of the benign cases, 78% were interpreted as proliferative breast lesion without atypia. CONCLUSIONS: Proliferative breast lesion with atypia was clinically significant because it was associated with a significantly increased likelihood of malignancy compared with proliferative breast lesion without atypia. Most of the malignancies had hypocellularity or low nuclear grade on the FNA smears. Fibroadenoma accounted for most of the benign lesions in both proliferative breast lesion and proliferative breast lesion with atypia.
Subject(s)
Breast Diseases/classification , Breast Diseases/pathology , Breast/pathology , Adolescent , Adult , Aged , Biopsy, Fine-Needle , Breast Neoplasms/classification , Breast Neoplasms/pathology , Child , Cytodiagnosis/methods , Diagnosis, Differential , Female , Humans , Hyperplasia , Middle Aged , Precancerous Conditions/classification , Precancerous Conditions/pathology , Young AdultABSTRACT
With the advent of modern therapy, the differences in prognoses and treatment regimens among different subtypes of Hodgkin lymphoma (HL) have largely vanished. Stage and the presence of systemic symptoms are much more important than histologic subtypes as predictive factors. The current (2001) WHO classification markedly de-emphasizes spatial relationships as critical to the diagnosis of lymphoma and emphasizes cell morphology, immunophenotype, genetic features, and clinical information to define the disease states. This classification, thus, greatly enhances the capability of fine-needle aspiration (FNA) to accurately diagnose HL. We searched all the FNA cases in our institute in years 1999 through 2004 and found 42 cases, for which 13 were primarily diagnosed (31.0%), 2 were recurrent (4.8%), 5 were highly suspicious (11.9%), and 22 were suspicious (52.3%) for HL. On follow-up tissue biopsy, all the primarily diagnosed, recurrent, and highly suspicious cases were confirmed to be HL (100% agreement). For the 22 suspicious cases, 13 were HL (59.1%), 5 were other lymphomas (22.8%), 1 was lymphoma unclassifiable (4.5%), and 3 were reactive processes (13.6%). The effect of immunostains on the diagnosis of HL was examined, and its importance was emphasized. Analysis of demographic data and the distribution of HL subtypes demonstrate that the study sample is representative of the general HL patient population. On the basis of these results, we propose: (1) If the FNA diagnosis of HL is confirmed both by morphology and immunostains, no further tissue confirmation, subclassification and grading is necessary, and appropriate treatment regimens should follow. (2) The nodular lymphocyte predominant HL and classical HL can be differentiated by adequate immunostaining. (3) If a definitive diagnosis cannot be achieved by FNA, a second FNA or a tissue biopsy should be recommended.
Subject(s)
Biopsy, Fine-Needle , Hodgkin Disease/classification , Hodgkin Disease/diagnosis , Adolescent , Adult , Antigens, CD/metabolism , Biomarkers, Tumor/analysis , Female , Hodgkin Disease/metabolism , Humans , Immunohistochemistry , Male , Middle Aged , Retrospective Studies , Sensitivity and SpecificityABSTRACT
Pleomorphic lipoma is a rare soft-tissue tumor, most commonly seen in the head and neck regions of middle-aged men. Fine-needle aspiration (FNA) of these lesions can present a diagnostic challenge. Its large, hyperchromatic cells and multinucleated forms (floret cells) can easily be mistaken for a malignancy. A patient with a round, well-circumscribed, painless, soft, subcutaneous posterior neck mass for 6 yr presented to our FNA clinic. Aspiration of the mass showed a hypocellular specimen with atypical large and floret cells with fragments of mature fibroadipose tissue in the background. Based on the clinical and cytomorphological findings, a diagnosis of pleomorphic lipoma was suggested, and it was confirmed on excision. This case highlights the need to be aware of unusual benign lesions that may arise in the head and neck region. Knowledge of these benign lesions will help in making the correct cytological diagnosis when these lesions are sampled by FNA.
Subject(s)
Adipose Tissue/pathology , Head and Neck Neoplasms/pathology , Lipoma/pathology , Biopsy, Fine-Needle , Humans , Male , Middle AgedABSTRACT
Adenoid cystic carcinoma (ACC) is most often primary in the major and minor salivary glands but can also arise from the submucosal seromucinous glands of the larynx and trachea. We report a case of adenoid cystic carcinoma of the larynx that presented as a diffuse swelling in the thyroid area. Fine-needle aspiration (FNA) was consistent with a neoplastic process, which was difficult to classify further but was felt to be of thyroid origin. Subsequent gross and histopathologic examination showed the lesion to represent an ACC arising from the larynx. This case highlights the need to be aware of unusual lesions that may arise in the region of the thyroid. Knowledge of these non-thyroidal lesions that can clinically mimic a thyroid mass will help in making the correct cytologic diagnosis when these lesions are sampled by FNA.
Subject(s)
Carcinoma, Adenoid Cystic/pathology , Laryngeal Neoplasms/pathology , Thyroid Neoplasms/pathology , Aged , Biopsy, Fine-Needle , Diagnosis, Differential , Humans , MaleABSTRACT
The clinical and pathologic features of 51 cases of pilomatrixoma found in our archives from 1990-1999 were reviewed, with emphasis on the cytopathologic features of the 22 cases that were sampled by fine-needle aspiration (FNA) biopsy prior to excision. Although uncommon, almost 20% of the pilomatrixomas in this series occurred in adults over age 30. Of the commonly reported features, the presence of basaloid cells and ghost cells in FNA smears, associated with a cutaneous location of the lesion, was sufficient for a confident cytologic diagnosis of pilomatrixoma. The presence of foreign body-type giant cells, nucleated squamous cells, and calcification, alone or in combination, was less specific, but supported a diagnosis of pilomatrixoma. Although infrequently reported, prominent nucleoli in basaloid cells and smears containing refractile keratin clumps were very useful clues in the diagnosis of pilomatrixoma. Finally, the routine use of cell blocks is recommended because in many of the cases presented ghost cells were fragmented or obscured in smears, but were more readily identified in cell block sections.