1.
J Nat Prod
; 64(12): 1559-61, 2001 Dec.
Article
in English
| MEDLINE
| ID: mdl-11754612
ABSTRACT
Pibocin B (2), the first representative of marine alkaloids with a unique structural feature, an N-O-methylindole group, was isolated from the Far-Eastern ascidian Eudistoma sp. Its structure has been established as (8 beta)-2-bromo-N-O-methyl-6,8-dimethylergoline on the basis of NMR data, FAB and MALDI-TOF MS, and chemical correlations. Pibocin B showed moderate cytotoxic activity against mouse Ehrlich carcinoma cells.
Subject(s)
Anti-Infective Agents/isolation & purification , Antifungal Agents/isolation & purification , Antineoplastic Agents/isolation & purification , Indole Alkaloids/isolation & purification , Urochordata/chemistry , Animals , Anti-Bacterial Agents , Anti-Infective Agents/chemistry , Anti-Infective Agents/pharmacology , Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Bacillus subtilis/drug effects , Candida albicans/drug effects , Carcinoma, Ehrlich Tumor , Crystallography, X-Ray , Indole Alkaloids/chemistry , Indole Alkaloids/pharmacology , Mice , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Russia , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization , Staphylococcus aureus/drug effects , Tumor Cells, Cultured/drug effects
2.
J Nat Prod
; 58(2): 254-8, 1995 Feb.
Article
in English
| MEDLINE
| ID: mdl-7769392
ABSTRACT
Varacin [1] and three new antimicrobial marine polysulfides, varacins A-C [3-5], have been isolated from the Far Eastern ascidian Polycitor sp. Their structures have been elucidated by spectroscopic methods and by chemical transformations.
