ABSTRACT
Peripheral nerve injuries not repaired in an effective and timely manner may lead to permanent functional loss and/or pain. For gaps greater than 5 mm, autograft has been the gold standard. Allograft has recently emerged as an attractive alternative, delivering comparable functional recovery without risk of second surgical site morbidities. Cost is an important factor when considering surgical options, and with a paucity of nerve repair cost data, this study aimed to compare allograft and autograft procedure costs. Methods: A retrospective cross-sectional observational study using the US all-payer PINC AI Healthcare Database examined facility procedure costs and cost drivers in patients undergoing allograft or autograft repair of an isolated single peripheral nerve injury between January 2018 and August 2020. Inpatient repairs were limited to nerve-specific DRGs. Multivariable regression evaluated risk-adjusted procedure cost differences. Results: Peripheral nerve graft repairs (n = 1363) were more frequent in the outpatient setting, and more than half involved the use of allograft nerve. Procedure costs for allograft and autograft repair were not significantly different in the outpatient (P = 0.43) or inpatient (P = 0.71) setting even after controlling for other risk factors. Operating room cost was significantly higher for autograft in outpatient (P < 0.0001) but not inpatient (P = 0.46), whereas allograft implant cost was significantly higher in both settings (P < 0.0001). Conclusions: No significant differences in procedure costs for autograft and allograft repair in inpatient and outpatient settings were found using real-world data. Future research should explore longer-term costs.
ABSTRACT
PURPOSE: Tendon reconstruction is frequently required under conditions of tendon deficiency. The authors sought a technique that could obviate the need for tendon harvest yet meet the minimum load of 45 N required for an early active motion protocol. This study was designed to determine the ideal suture construct utilizing the tendon with Z-lengthening (TWZL) technique. METHODS: Sixty fresh-frozen cadaveric flexor digitorum profundus tendons of the index, middle, and ring fingers were randomized into 5 different TWZL construct designs using 3-0 braided polyethylene suture. Constructs were tested on an electromechanical actuator until failure was observed on the load-elongation recording. Data points on maximum yield and load at 8% strain were recorded for each construct. RESULTS: The maximum yield data revealed the construct with a 4-core suture type configuration (construct #4) had the highest overall mean load to failure at 150 N compared with all other constructs. The construct with the highest mean load at 8% strain was that with a 4-core type repair (construct #4) at 59 N. The constructs with Krackow locking sutures (constructs #2, #3, and #4 were found to withstand a significantly higher mean load at 8% strain than those without Krackow sutures (#0 and #1). Comparison among constructs with Krackow locking sutures #2 (56 N), #3 (48 N), and #4 (59 N) did not show a significant difference in mean load at 8% strain. Construct #3, however, had an SD and 95% confidence interval that fell below the 45 N early active motion threshold, whereas both #2 and #4 had 95% confidence intervals that fell no lower than 50 N. CONCLUSIONS: This study provides evidence that the TWZL technique utilizing either construct #2 or #4 could provide sufficient strength and reproducibility for tendon reconstruction. CLINICAL RELEVANCE: The study describes the application of the TWZL technique for utilization in tendon reconstruction and quantifies differences in the yield strengths of the 5 proposed constructs.
