A Causality-guided Statistical Approach for Modeling Extreme Mei-yu Rainfall Based on Known Large-scale Modes-A Pilot Study.

Extreme Mei-yu rainfall (MYR) can cause catastrophic impacts to the economic development and societal welfare in China. While significant improvements have been made in climate models, they often struggle to simulate local-to-regional extreme rainfall (e.g., MYR). Yet, large-scale climate modes (LSCMs) are relatively well represented in climate models. Since there exists a close relationship between MYR and various LSCMs, it might be possible to develop causality-guided statistical models for MYR prediction based on LSCMs. These statistical models could then be applied to climate model simulations to improve the representation of MYR in climate models. In this pilot study, it is demonstrated that skillful causality-guided statistical models for MYR can be constructed based on known LSCMs. The relevancy of the selected predictors for statistical models are found to be consistent with the literature. The importance of temporal resolution in constructing statistical models for MYR is also shown and is in good agreement with the literature. The results demonstrate the reliability of the causality-guided approach in studying complex circulation systems such as the East Asian summer monsoon (EASM). Some limitations and possible improvements of the current approach are discussed. The application of the causality-guided approach opens up a new possibility to uncover the complex interactions in the EASM in future studies.

A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology.

Surfactants, whose existence has been recognized as early as 2800 BC, have had a long history with the development of human civilization. With the rapid development of nanotechnology in the latter half of the 20th century, breakthroughs in nanomedicine and food nanotechnology using nanoparticles have been remarkable, and new applications have been developed. The technology of surfactant-coated nanoparticles, which provides new functions to nanoparticles for use in the fields of nanomedicine and food nanotechnology, is attracting a lot of attention in the fields of basic research and industry. This review systematically describes these "surfactant-coated nanoparticles" through various sections in order: 1) surfactants, 2) surfactant-coated nanoparticles, application of surfactant-coated nanoparticles to 3) nanomedicine, and 4) food nanotechnology. Furthermore, current progress and problems of the technology using surfactant-coated nanoparticles through recent research reports have been discussed.

Influence of quercetin on the global DNA methylation pattern in pigs.

The plant flavonol quercetin causes multiple health-promoting effects in human and animals. In this study, we investigated the possible effects of quercetin on global DNA methylation in growing pigs after 7 weeks of feeding a quercetin-enriched diet. The results indicated that a trend for an improved feed conversion was observed in the quercetin fed group compared to the control group. Furthermore, quercetin influenced global DNA methylation by upregulating DNA methyltransferase 1 (DNMT1) in both mRNA and protein expressions in a tissue specific manner. The observed bioactivity of quercetin against the global methylation marker in pigs indicates that quercetin could be a potential inducer of DNA methylation which might be of economic significance for effective nutritional interventions affecting the health and productivity of animals.

Vitamin E: Regulatory Redox Interactions.

Vitamin E is an essential nutrient that was discovered in the 1920s. Many of the physiological functions of vitamin E, including its antioxidative effects, have been studied for nearly 100 years. Changes in redox balance induced by both endogenously and exogenously generated reactive oxygen species (ROS) are involved in various diseases, and are also a phenomenon that is considered essential for survival. Vitamin E is known to regulate redox balance in the body due to its high concentration among the lipid soluble vitamin groups, and exists ubiquitously in the whole body, including cell membranes and lipoproteins. However, it has been reported that the beneficial properties of vitamin E, including its antioxidative effects, are only displayed in vitro, and not in vivo. Therefore, there exists an ongoing debate regarding the biological functions of vitamin E and its relationship with redox balance. In this review, we introduce the relationship between vitamin E and redox interactions with (i) absorption, distribution, metabolism, and excretion of vitamin E, (ii) oxidative stress and ROS in the body, (iii) mechanism of antioxidative effects, (iv) non-antioxidant functions of vitamin E, and (v) recent recognition of the field of oxidative stress research. Understanding the recent findings of the redox interaction of vitamin E may help to elucidate the different antioxidative phenomena observed for vitamin E in vitro and in vivo. © 2019 IUBMB Life, 71(4):430-441, 2019.

Modelling serial clustering and inter-annual variability of European winter windstorms based on large-scale drivers.

Winter windstorms are known to be among the most dangerous and loss intensive natural hazards in Europe. In order to gain a better understanding of their variability and driving mechanisms, this study analyses the temporal variability which is often referred to as serial or seasonal clustering. This is realized by developing a statistical model relating the winter storm counts to known teleconnection patterns affecting European weather and climate conditions (e.g., North Atlantic Oscillation [NAO], Scandinavian pattern [SCA], etc.). The statistical model is developed via a stepwise Poisson regression approach that is applied to windstorm counts and large-scale indices retrieved from the ERA-20C reanalysis. Significant large-scale drivers accountable for the inter-annual variability of storms for several European regions are identified and compared. In addition to the SCA and the NAO which are found to be the essential drivers for most areas within the European domain, other teleconnections (e.g., East Atlantic pattern) are found to be more significant for the inter-annual variability in certain regions. Furthermore, the statistical model allows an estimation of the expected number of storms per winter season and also whether a season has the characteristic of being what we define an active or inactive season. The statistical model reveals high skill particularly over British Isles and central Europe; however, even for regions with less frequent storm events (e.g., southern and eastern Europe) the model shows adequate positive skill. This feature could be of specific interest for the actuarial sector.

Climate and socioeconomic influences on interannual variability of cholera in Nigeria.

Cholera is one of the most important climate sensitive diseases in Nigeria that pose a threat to public health because of its fatality and endemic nature. This study aims to investigate the influences of meteorological and socioeconomic factors on the spatiotemporal variability of cholera morbidity and mortality in Nigeria. Stepwise multiple regression and generalised additive models were fitted for individual states as well as for three groups of the states based on annual precipitation. Different meteorological variables were analysed, taking into account socioeconomic factors that are potentially enhancing vulnerability (e.g. absolute poverty, adult literacy, access to pipe borne water). Results quantify the influence of both climate and socioeconomic variables in explaining the spatial and temporal variability of the disease incidence and mortality. Regional importance of different factors is revealed, which will allow further insight into the disease dynamics. Additionally, cross validated models suggest a strong possibility of disease prediction, which will help authorities to put effective control measures in place which depend on prevention, and or efficient response.

Position-resolved determination of trace elements in mandibular gnathobases of the Antarctic copepod Calanoides acutus using a multimethod approach.

Previous studies have revealed silica formation in the teeth of mandibular gnathobases of copepods while significant amounts of zinc and copper are present, which might improve mechanical stability of the teeth and represent an adaptation to compact food particles. The present study aimed at analysing the distribution and concentration of trace elements in the mandibular gnathobases of females of the Antarctic copepod species Calanoides acutus. Because of the low overall masses of few micrograms per specimen the application of a combination of position-resolved micro-beam techniques was necessary and micro-particle-induced X-ray emission spectrometry and laser ablation inductively coupled plasma mass spectrometry were used to determine Ba, Br, Ca, Cl, Cu, Fe, K, Mg, Na, Ni, P, S, Si and Zn in the samples with µm to sub-µm resolution. Calibration strategies were optimised to fit for the carbonate matrix. The analyses revealed a distinct enrichment of Br, Ca, Fe, K, S, Si and Zn in the teeth of the gnathobases.

Conformational plasticity in an HIV-1 antibody epitope.

The structure of a short fragment of the human HIV-1 membrane glycoprotein gp41 has been examined using a combination of parallel tempering molecular dynamics (PTMD) and far UV circular dichroism spectroscopy. The aim is to resolve conflicting reports on the solution state conformational bias in this membrane proximal domain spanning the epitope for the 2F5 monoclonal antibody. We conclude that gp41(659-671) exhibits conformational plasticity in which competing folding propensities are present and can be influenced by local microenvironment. Contrary to previous reports, the 3(10) helix does not emerge as a dominant motif from either simulation or experiment, and this peptide is therefore not a model system for this fold type. Other fold groups such as turn motifs are identifiable at elevated temperatures in the PTMD trajectories and are potentially relevant in antibody binding. Helical populations in pure water are significantly overestimated according to the CHARMM parametrization. However, circular dichroism (CD) data show that helices are promoted in membrane mimetic solvents. As this is a membrane proximal peptide, the helical motif may well have physiological significance.

Discordance between physicians and coders in assignment of diagnoses.

OBJECTIVE: To measure concordance between physicians and medical record coders in their assignment of diagnoses. DESIGN: Prospective cohort series. SETTING: Five hundred and fifty-bed, tertiary-care, university teaching hospital. Study participants. In-patients who were discharged from either the Cardiac Sciences Program (n=125), the Renal Program (n=43), or the HIV-AIDS Program (n=25) during the period May 18-July 1, 1995. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Physicians and coders assigned diagnoses for individual in-patients based on their independent interpretations of the patient chart and discharge summary sheet. All assigned diagnoses were coded using the ICD-9-CM classification system. Concordance was measured for the most responsible diagnosis and for all assigned diagnoses. Difference in calculated resource intensity weights based on physicians' and coders' assignment of diagnoses was also calculated. RESULTS: Concordance rates for the most responsible diagnosis in each program were: Cardiac Sciences [27%; 95% confidence interval (CI)=20-36%], Renal Program (35%; 95% CI=21-53%), and HIV-AIDS Program (20%; 95% CI, 6-41%). Concordance rates for all diagnoses per chart were similar: Cardiac Sciences (20%; 95% CI, 14-25%), Renal Program (25%; 95% CI, 20-33%), and HIV-AIDS Program (29%; 95% CI, 25-44%). Resource intensity weights assigned by coders for the Cardiac Sciences and HIV-AIDS Program were significantly higher than those assigned by the physicians.

Reduced length of stay and improved appropriateness of care with a clinical path for total knee or hip arthroplasty.

BACKGROUND: In 1991 the orthopedics department at St Paul's Hospital, Vancouver, British Columbia, Canada, identified the clinical path as a way to shorten length of stay, improve efficiency of resource use, and minimize variation in care processes without compromising clinical outcomes for patients admitted for elective knee or hip arthroplasty. METHODS: A team of direct care providers collected baseline data for 77 patients to identify variables influencing length of stay (LOS) and variability in care processes. The team proposed an improved sequence of coordinated clinical decisions and treatments on a daily basis. The clinical path was disseminated by educating nursing and medical staff and by developing pre-printed orders and modifying the nursing care plan. RESULTS: Nine months after implementation of the clinical path, there was a statistically significant reduction in median LOS (12 to 9 days; p < 0.001), which was sustained for at least 18 additional months. Decreased use of inappropriate perioperative antibiotics and laboratory tests and no change in postoperative complications or readmission rate were also found. DISCUSSION: A new team is now developing a clinical path for hip fracture patients. In addition, other programs are using the template employed by the arthroplasty team to develop clinical paths for acute myocardial infarction, coronary artery bypass grafting, stroke, and drug overdose in the intensive care unit. SUMMARY: The team is now working toward a seven-day LOS for these patients. This experience has served as a model for development and implementation of other clinical paths for other groups of patients at the hospital.

[Socioeconomic factors in high risk pregnancy]. / Factores socioeconómicos en el embarazo de alto riesgo.

PIP: The study of high risk during pregnancy was undertaken to show the most viable ways for solving those problems affecting maternal-fetal morbidity and mortality. The authors are hopeful that in the future, the 2 branches of medicine, perinatology and obstetrics, will no longer differentiate between high risk for mother and fetus or neonate but will direct attention to what is high risk for 1 society in particular. These professionals will undertake an interdisciplinary approach of the problem to benefit society. (author's)^ieng