Behavioural changes in adult rats following administration of antibodies again brain gangliosides.

Mature rats, previously trained in a standard two-lever chamber, were injected with antibodies against ganglioside and the effect was evaluated in a series of different behavioural tests. Compared with the controls, the injected rats showed transient differences in their response to stimuli. The apparent counter-intuitive superiority of the treated animals over the controls is discussed with reference to other experimental studies performed in young rats, and to discrete pathological human conditions associated with the presence of brain antibodies.