[Method for determination the action of psychoactive agents on the central nervous system based on the molecular docking method]. / Sposob ustanovleniya deistviya na tsentral'nuyu nervnuyu sistemu psikhoaktivnykh soedinenii na osnove metoda molekulyarnogo dokinga.

A large number of narcotic substances are currently being synthesized. In 2018, at least one drug with a new chemical formula was created and distributed around the world every week. In a number of countries, it became necessary to change legislation to optimize the regulation of drug trafficking to speed up and simplify the procedure for adding chemical compounds to the list of drugs. The new global legal and regulatory terminology has made it possible to approach the definition of «psychoactive substance¼ from a legal and medical point of view. The legislative definitions of medical organizations have been clarified that have determined the main features of new psychoactive substances: the possibility of influencing the human nervous system and the ability to form addictive behavior. The problem in the production of forensic medical examination is the answer to the question about the state of drug intoxication (poisoning) of a person from the action of a new psychoactive substance in the absence of information about the clinical picture of intoxication (poisoning). The proposed method of molecular docking allows confirming the possibility of a chemical substance acting on the human nervous system to determine the similarity with the effects of drugs and to consider the properties of a chemical compound as the properties of a "new psychoactive substance". Molecular docking - modeling the interaction of a bio-target - a human receptor protein sensitive to a drug with a ligand - a drug. The method allows to determine the fundamental possibility of a chemical reaction between molecules, as well as to estimate the reaction energy for the isolation of the most chemically active ligands.

[Prognostic criteria for the forensic diagnosis of acute drug poisoning at the stage of study of corpse]. / Prognosticheskie kriterii sudebno-meditsinskoi diagnostiki ostrykh otravlenii narkotikami na etape issledovaniya trupa.

We studied the morphological criteria that allow us to assess the need to send biological material to a forensic chemical study based on the results of a forensic medical study of a corpse in cases of suspected acute drug poisoning. According to a statistical analysis, it was determined that under the condition of death with a fast agonal period, the most characteristic prognostic signs of acute drug poisoning are young age, the presence of traces of injections and/or «wells¼, lung mass more than 1050 g, the sum of the size of the spleen exceeding 25. The use of a combination of the three indicated characteristic signs encountered in acute drug poisoning can increase the likelihood of detecting acute poisoning with psychoactive substances. Taking into account the tendency of recent years to increase the age of drug users, the possibility of using exclusively morphological characters has been objectively proven while maintaining the specificity of the diagnosis of acute drug poisoning.

[Traumatic brain injury in drug users]. / Cherepno-mozgovaya travma u narkopotrebitelei.

We assessed the incidence of mechanical injury in drug users. Incidence was 21.9% and exceeds the global average injury rate by 2.4 times Mortality from mechanical injury among drug users ranges from 4.46% to 5%. This value is 4.46-5%, which is 64-71 times higher than the average mortality rates from injury and 89-100 times higher than trauma mortality rate in Russia. Psychoactive drugs from the groups of neurostimulators and neurodepressors have a significant impact on the course of traumatic brain injury; hallucinogens only increase the risk of traumatic injury. In cases of mild traumatic brain injury and concussion combined with drug intoxication, the action of the psychoactive drug is the leading link of pathogenesis. In cases of moderate to severe traumatic brain injury combined with drug intoxication, craniocerebral trauma determines the outcome.