Intravenous leiomyomatosis.

Intravenous leiomyomatosis is a rare tumor in which benign smooth muscle cells grow into the pelvic venous channels of female patients. A case of intravenous leiomyomatosis with cardiac extension in a 45-year-old woman is described. The patient was diagnosed with cardiac syncope 3 months after total abdominal hysterectomy and was successfully treated with a two-stage approach consisting of sternotomy followed by laparotomy. The cause, disease, presentation, diagnosis, treatment and recurrence are reviewed.

Role of the neutrophil in abdominal aortic aneurysm development.

Elastase release by neutrophils has been implicated in the etiology of abdominal aortic aneurysm (AAA). The present study investigated whether neutrophils in patients with AAA actively synthesize the neutrophil elastase enzyme and the effect of elastin-derived peptides on neutrophil elastase release. Total neutrophil elastase in patients with AAA was significantly higher than in those with aortic occlusive disease and controls. The neutrophil elastase gene was not expressed in any patient group. Elastin-derived peptides induced elastase release, which was significantly higher in patients with AAA than in those with aortic occlusive disease and controls. These data indicate that the peptides of elastin degradation stimulate the release of elastase, but that continuing production of elastase is absent in circulating neutrophils. It is concluded that: (1) neutrophils do not actively synthesize elastase but act as 'mules' or carriers of the enzyme; and (2) elastin breakdown products stimulate the release of elastase at the aortic wall by circulating neutrophils, which in patients with AAA have a predetermined increased amount of elastase.

Greenfield filter instead of heparin as primary treatment for deep venous thrombosis or pulmonary embolism in patients with cancer.

BACKGROUND AND METHOD: During the last 5 years, the authors placed Greenfield filters as primary therapy in 41 patients with cancer with deep venous thrombosis (DVT) and/or pulmonary embolism (PE) instead of administering heparin. RESULTS: There were no operative deaths. Complications included erythema of the incision in one patient, recurrent PE in one patient, and chronic filter prong penetration of the inferior vena caval wall in one patient. Follow-up was complete for 90% (37 of 41) of the patients. Forty-six percent of the patients died of their cancer early in the study. In follow-up, leg swelling improved completely or partially in 74.5% of patients and was unchanged in 22% of patients. The condition of one patient worsened secondary to recurrent DVT. The patients with improved symptoms also had improved functional ability, whereas those whose condition did not change were mostly bedridden, many with end-stage advanced metastatic disease. CONCLUSIONS: These results indicate that Greenfield filter insertion is safe and effective as primary therapy in patients with cancer with DVT and/or PE.

Endothelial cell injury in human saphenous veins following use of a circular valvulotome.

With increasing use of nonreversed saphenous vein as a bypass conduit (either in-situ or translocated) several techniques of valve ablation are used. The present study was designed to assess the extent of endothelial damage caused by a circular blade valvulotome.

Increased intestinal permeability: implications for thoracoabdominal aneurysm repair.

Coagulopathy and massive bleeding plays a major role in the mortality of thoraco-abdominal aneurysm repair. Increasing supraceliac aortic cross-clamp time from 0 to 90 minutes increases the degree of disseminated intravascular coagulation, which occurs as a result of occlusion and reperfusion of the superior mesenteric artery. The purpose of this study was to investigate the mechanism of the superior mesenteric artery reperfusion disseminated intravascular coagulation. Twenty dogs were divided into four groups: cross-clamp time of 30 minutes; cross-clamp time of 60 minutes; cross-clamp time of 90 minutes; and control. Permeability was determined by lactulose/mannitol absorption. The venous effluent was sampled for endotoxin, potassium, bacteria, and pH every hour and urine was collected for six hours. Lactulose absorption was significantly higher in all of the experimental groups. There was increased permeability in the 60 and 90 minute groups which correlated significantly with time. Venous endotoxin, potassium, and blood cultures for bacteria did not change significantly. The pH was significantly lower every hour for six hours in the 90 minute group. These data suggest that intestinal permeability is increased with supraceliac aortic clamping and can be kept to a minimum for clamp times of under one hour.