1.
Bioorg Med Chem Lett
; 14(14): 3727-31, 2004 Jul 16.
Article
in English
| MEDLINE
| ID: mdl-15203151
ABSTRACT
Through structure-based drug design and parallel synthesis, we have discovered a novel series of nonpeptidic phenyl-based thrombin inhibitors using oxyguanidines as guanidine bioisosteres. These compounds have been found to be highly potent, highly selective, and orally bioavailable.