ABSTRACT
The effect of hepatitis Bs-antigen (AgHBs) and anti-hepatitis C virus (HCV) positivity on renal transplant outcomes is still controversial. Some studies describe higher rates of acute rejection and allograft loss, and greater mortality in transplant recipients with hepatitis. We retrospectively evaluated data from 2284 allograft recipients who underwent transplantation at our hospital between July 1980 and December 2012. Statistical analysis was made using chi-square and Student t tests, Kaplan-Meier curves, and survival analysis. We identified 62 AgHBs+ patients, 99 anti-HCV+ patients, and 14 AgHBs+/anti-HCV+ patients; 2109 patients had "no hepatitis." Mean follow-up time was 7.93 years. No statistical differences were identified on allograft acute rejection rate or patient survival between groups. AgHBs+ patients had, however, an inferior allograft survival, with statistical significance. According to our study, hepatitis B has a harmful impact on allograft survival, although it does not compromise the patient survival.
Subject(s)
Graft Rejection/epidemiology , Hepatitis B/complications , Hepatitis C/complications , Kidney Failure, Chronic/surgery , Kidney Transplantation , Acute Disease , Adult , Case-Control Studies , Cohort Studies , Female , Graft Rejection/mortality , Graft Survival , Hepacivirus/immunology , Hepatitis B/immunology , Hepatitis B Surface Antigens/immunology , Hepatitis B virus/immunology , Hepatitis C/immunology , Humans , Kidney Failure, Chronic/complications , Kidney Transplantation/mortality , Male , Middle Aged , Retrospective Studies , Survival Analysis , Transplantation, HomologousABSTRACT
Chronic kidney disease and sexual dysfunction are common entities in clinical practice in haemodialysis (HD) units. This article is a review of some articles that focus on sexual dysfunction in patients undergoing HD and its possible relationship in multiple ways.
