Subject(s)
AIDS-Associated Nephropathy/etiology , Alopecia/etiology , Dermatitis/etiology , HIV Infections/diagnosis , HIV-1 , AIDS-Associated Nephropathy/pathology , Adult , Antigens, Differentiation, T-Lymphocyte/analysis , CD4 Antigens/analysis , CD8 Antigens , Dermatitis/pathology , Diagnosis, Differential , Female , HIV Infections/blood , HIV Infections/complications , HumansABSTRACT
Inflammatory muscle involvement during the course of human immunodeficiency virus (HIV) infection is described and guidelines are suggested for its differentiation from the myopathy associated with azidothymidine (AZT) therapy. Six patients infected with HIV presented with proximal muscle weakness, biochemical and electromyographic abnormalities consistent with myositis. One patient had a skin rash characteristic of dermatomyositis. Muscle biopsy findings demonstrated the presence of an inflammatory cell infiltrate and HIV-p24 antigen. All patients developed their clinical picture prior to AZT therapy and responded to steroids with or without coadministration of AZT.
Subject(s)
HIV Infections/complications , Muscular Diseases/chemically induced , Myositis/etiology , Zidovudine/adverse effects , Adult , Dermatomyositis/diagnosis , Dermatomyositis/etiology , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Muscular Diseases/diagnosis , Myositis/diagnosisABSTRACT
The association between the recently described eosinophilia-myalgia syndrome and L-tryptophan is now well established. We describe a patient with eosinophilia-myalgia syndrome who developed incapacitating myalgias and peripheral eosinophilia responsive only to high dose corticosteroids. When massive upper gastrointestinal hemorrhage developed while receiving corticosteroid therapy, surgery was complicated by striking abdominal wall rigidness. A discussion of this case and of eosinophilia-myalgia syndrome is presented.
