1.
Bioorg Med Chem Lett
; 20(12): 3579-83, 2010 Jun 15.
Article
in English
| MEDLINE
| ID: mdl-20483614
ABSTRACT
A series of 5-arylamino-1,2,4-triazin-6(1H)-ones was synthesized and evaluated as antagonists at the corticotropin releasing factor receptor. Formation of CYP-mediated oxidative reactive metabolites previously observed in a related N(3)-phenylpyrazinone structure was minimized by incorporation of the additional ring nitrogen found in the triazinones.