[The clinical and immunological manifestations of food intolerance in obese patients].

The clinical and immunological manifestations of food intolerance in obese patients were studied. Food intolerance was diagnosed in 32.6 and 33.4% in obese patients stage 2 and stage 3 respectively, and was basically determined by 13 proteinaceous food products. The changes in immune status in obese patients created conditions for development of food intolerance. The timely diagnose food intolerance allows to personalize the diet therapy.

[Body composition in patients with different degree of obesity before and after dietetic correction].

The study included 400 patients with I-III obesity degree. All patients were tested before and after hypocaloric diet with energy value of 1600 kcal/day within 2 weeks. The bioimpedance analysis was spent on device "Inbody 720". The application of the hypocaloric diet is accompanied by clinically significant decrease in body weight in patients with obesity mainly due to the fatty component and visceral fat area and positive dynamics of clinical and biochemical parameters.

[Food status peculiarities, anthropometric, clinica and biochemical indices at professional sportsmen].

Under steady state conditions in 66 athletes involved in weightlifting, bodybuilding, judo and taekwondo have studied features of the metabolic status. Data on matter-of-fact nutrition, body weight content within the inter-competition period, energy exchange, clinical and biochemical indices and physical acceptability indices were analyzed. As a result, the decrease indexes of metabolism at all the sportsmen and high-level caloric value at sportsmen who are engaged in weightlifting, which corresponds their energy expenditures, was revealed.

[Experience in using the biologically active additive "miprovit" in the treatment of various metabolic diseases]. / Opyt primeneniia biologicheski aktivnoi dobavki "miprovit" v lechenii nekotorykh boleznei metabolizma.

Using of protein and vitamin enriched preparation "Miprovit" in treatment of 90 patients with obesity showed decreasing effect on serum cholesterol and glucose levels and coefficient of atherogenity which were increased in these patients. Decreasing of appetite and feeling of hungry were noted in 75% of patients. "Miprovit" favoured more comfortable feeling of patients during course of body weight reduction.

[Changes in the lipid composition of the lymphocyte membranes and in the reactions of the lymphocytic Fc receptors in obesity]. / Izmeneniia lipidnogo sostava membran limfotsitov i reaktsii limfotsitarnykh Fc-retseptorov pri ozhirenii.

The paper is concerned with a study of a response of lymphocytic Fc receptors (FcR) to modulators regulating their expression (prostaglandins E2 and F2, 2 X 10(-9) M, isoproterenol 10(-5), 10(-6) M) as compared to changes in the lymphocyte membrane lipid composition of patients with obesity of II-III degree with a high blood cholesterol level up to 9-10 nmol/l. Two groups were distinguished among obese patients: "areactive" in which lymphocytic FcR did not respond to modulators, and "reactive" in which FcR responded at least to one of 4 utilized modulators. Research into the lipid spectrum of lymphocytic membranes revealed a significant decrease in the concentration of nonesterified fatty acids in membranes of "areactive" lymphocytes to 4 +/- 0.6% (against the normal level of 8.9 +/- 0.7%). In order to make up completely for immunodeficiency in obesity, lipotropic agents and food rich in polyunsaturated fatty acids could be recommended.

[Effect of a diet with an elevated protein quota on the immune status in the malabsorption syndrome]. / Vliianie diety s povyshennoi kvotoi belka na immunnyi status pri sindrome narushennogo vsasyvaniia.

The immune status was examined in 126 patients with malabsorption. Of these, 100 subjects suffered from chronic enteritis of varying severity. Twenty-six patients developed malabsorption after extensive resection of the small intestine. Lymphocyte proliferation and migration of peripheral blood leukocytes exposed to PHA served as immunologic criteria. The secondary immunodeficient status ascertained by the authors correlated with the disease severity and stage. The diets differing in the protein quota (100, 130, 160 g) were applied as the basic therapeutic factor. The best effect was attained with the diet containing 130 g protein which makes it possible to use it for immunocorrection in secondary immunodeficient states of varying etiology.