[The effect of regulator peptides on pancreatic endocrine function in experimental acute pancreatitis]. / Vliianie reguliatornykh peptidov na éndokrinnuiu funktsiiu podzheludochnoi zhelezy pri éksperimental'nom ostrom pankreatite.

The comparative analysis of the influence on the glucose metabolism of rats in acute pancreatitis of synthetic analogues was made: somatostatin, calcitonin, leu-enkefalin-dalargin. It was shown that dalargin has the maximum normalizing effect as a result of its antistress qualities. Physiological reaction of beta-cells is preserved in infusion of somatostatin. However, infusion of calcitonin results in the distortion of counterregulatory action of insulin and glucagon.

[A comparative study of the effectiveness of regulatory peptides in acute experimental pancreatitis]. / Sravnitel'naia otsenka éffektivnosti reguliatornykh peptidov pri ostrom éksperimental'nom pankreatite.

The effect of regulatory peptides on the functional activity of pancreatic cells and phagocytic cells of reticuloendothelial system were determined in intact dogs against the background of acute experimental pancreatitis. Assessment of the efficacy of regulatory peptides was made with the aid of scintigraphic studies in gamma chamber using for this purpose colloid 198Au and 75Se-methionine. It was established that introduction of regulatory peptides to dogs leads to inhibition of capture of labeled methionine by pancreatocytes, practically not influencing the elimination of colloid gold from circulation.

[Effects of several regulatory peptides on the functional activity of the pancreas in acute experimental pancreatitis]. / Vliianie nekotorykh reguliatornykh peptidov na funktsional'nuiu aktivnost' podzheludochnoi zhelezy pri éksperimental'nom ostrom pankreatite.

The influence of regulatory peptides (somatostatin, calcitonin, and dalargin) on xanthine oxidase activity and lipid peroxidation level in pancreatic tissues as well as on the release of pancreatic enzymes (alpha-amylase, trypsin, lipase, and transamidinase) into blood was studied in 205 rats with experimental acute pancreatitis. Somatostatin and dalargin were shown to have obvious antioxidant effect seen by reduced xanthine oxidase activity and MDA level. All studied peptides stimulate reduced release of pancreatic enzymes. Particularly, reduction of dalargin and somatostatin is caused by inhibition of their synthesis as well as by pancreas protective effect of the peptides. Release of enzymes reduced by calcitonin is probably associated only with inhibition of secretory activity of the pancreas.

[Role of xanthine oxidase in the genesis of acute pancreatitis]. / Rol' ksantinoksidazy v geneze ostrogo pankreatita.

Experiments were conducted on 268 male albino rats with modeled acute pancreatitis to study the xanthine oxidase (XO) activity in the pancreatic tissue during intraperitoneal administration of stimulators of pancreatic exocrine function (pilocarpine) and inhibitors of enzyme activity (allopurinol). Pilocarpine (0.1 mg/kg) increased XO activity by 90-100% one-three hours after injection, which was due to increased synthesis of the enzyme. Allopurinol (500 mg/kg) inhibiting XO activity removes the XO activating effect of pilocarpine in the first two hours after injection. It was established that one of the tranquilizers of the 1,4-benzodiazepine series--seduxen (15 mg/kg) produces an inhibiting effect on XO activity and, like allopurinol, removes the XO activating effect of pilocarpine. Complete parallelism was also revealed between the dynamics of changes of XO activity in the pancreatic tissue and alpha-amylase in blood under the effect of the preparations studied.

[Dalargin in the prevention of acute postoperative pancreatitis]. / Dalargin v profilaktike ostrogo posleoperatsionnogo pankreatita.

In the experiment on 200 rats with acute pancreatitis, it was revealed that in administration of dalargin at a dose of 10 mg/kg of the mass, the activity of xanthinoxidase and lipid peroxidation in the pancreas was suppressed, at the same time, the activity of trypsin, amylase and transamidinase in the blood serum decreased. In 48 patients, who underwent the intravenous administration of dalargin at a dose of 50 mg/kg at operation on the pancreas and after it, the incidence of acute postoperative pancreatitis development decreased 4.16-fold when compared to the use of protease inhibitors, and 2.4-fold when compared to the use of fluorouracil.

[Changes in the external respiration function and hemodynamics after surgery of the pancreas]. / Izmenenie funktsii vneshnego dykhaniia i gemodinamiki posle operatsii na podzheludochnoi zheleze.

Pancreatic surgical operations, being very traumatic, cause considerable and lasting disorders on the part of external respiration, gas exchange, and central and regional hemodynamics. Patients with pancreatic tumors show systolic myocardial strain, which may be related to increased sympatho-adrenal influences. In the early days after pancreatoduodenal resection for pancreatic tumors, patients develop hyperdynamic circulation. Extensive use of neuropeptides is indicated as part of combined treatment preventing postoperative complications after pancreatic surgery.