[Comparative study of 2 combined treatment regimens in stage-III to -IV ovarian cancer]. / Sravnitel'noe izuchenie rezhimov kombinirovannogo lecheniia raka iaichnikov III-IV stadii.

The results of the treatment of 75 patients with ovarian carcinoma of epithelial origin are reported. The authors give a randomised clinical comparison of the efficacy of two schemes of complex treatment of 54 patients with ascitic ovarian carcinoma and 21 patients with non-ascitic ovarian carcinoma. The first scheme included cytoxan chemotherapy plus surgery plus polychemotherapy (25 patients); the second--surgery plus polychemotherapy (29 patients). Patients with non-ascitic carcinoma (21) received the second type of treatment. Polychemotherapy consisted of two alternating schedules: 5 fluorouracil plus cyclophosphamide and hexamethylamine plus cyclophosphamide after a two week interval. Better results were obtained in the group of patients treated surgically at the initial stage of treatment.

[Diagnosis and treatment of trophoblastic uterine tumors]. / Diagnostika i lechenie trofoblasticheskikh opukholei matki.

An evaluation of 801 cases of different forms of uterine trophoblastic tumors treated at the Center in 1960-1981 is given. Chorionepithelioma was confirmed histologically in 488 cases. Modern means of diagnosis of uterine trophoblastic tumors are discussed. A retrospective analysis of treatment of patients is presented. The result of up-to-date combination chemotherapy of patients with uterine chorionepithelioma are reported. The role of surgery in the treatment of trophoblastic tumors is discussed.

[Surgical method and combination chemotherapy in treating stage-III and IV ovarian cancer]. / Khirurgicheskii metod i kombinirovannaia khimioterapiia pri lechenii raka iaichnikov III-IV stadii.

The results of treatment of 50 patients with ovarian cancer (serous carcinoma) are reported. At the first step all the patients were treated surgically. Following the operation the combined chemotherapy was employed with three schedules: 1. 5-fluoruracil-cyclophosphane--26 patients; 2. 5-fluoruracil-cyclophosphane-methotrexate-hexamethyl melamine--16 patients; 3. fluorofur-cyclophosphane-methotrexate-hexamethyl melamine--8 patients. An analysis of the results of the treatment in ovarian cancer patients has demonstrated that a positive therapeutic effect may be gained using each of the schedules of the polychemotherapy employed, of special importance being such factors as the degree of tumor proliferation, radicality of surgical intervention and the magnitude of toxic reactions of antitumor drugs.

[Immunological reactivity study of patients with uterine trophoblastic tumors]. / Issledovanie immunologicheskoi reaktivnosti bol'nykh trofoblasticheskimi opukholiami matki.

By using DNCB delayed hypersensitivity test, the reaction of spontaneous rosette formation (RSRF) and the reaction of inhibition of leucocytes migration the authors examined 55 female patients with different forms of trophoblastic tumors of the uterus and 15 females following the removal of the mole without any signs of the disease concerned. Forty three patients showed a positive DNCB test, 93 of them were completely cured, a negative test was noted in 12 patients, only a 50% cure being observed. RSRF indicated the increased level of rosette-forming cells from 4,7--28% up to 10,3--73% in a successful treatment and its decrease down to 0--5% in the tumor progression, except 7 patients showing reduced RFC levels after the recovery. The reaction of leucocytes migration inhibition has revealed a considerable depression of leucocytes migration (MI--from 0.35 to 0.78) in 18 of 25 patients with manifestations of an acute tumor process (72%). In 7 cases no inhibition was noted, in 6--the treatment being insignificantly effective or time-consuming. In 21 (47.8%) of 27 patients without any signs of the affection there was no inhibitory effect. Leucocytes of healthy donors failed to respond to the tumor extract in either of 24 cases.