Intranasal fentanyl and inhaled nitrous oxide for fracture reduction: The FAN observational study.

INTRODUCTION: Procedural sedation and analgesia (PSA) are frequently used for fracture reduction in pediatric emergency departments (ED). Combining intranasal (IN) fentanyl with inhalation of nitrous oxide (N2O) allow for short recovery time and obviates painful and time-consuming IV access insertions. METHODS: We performed a bicentric, prospective, observational cohort study. Patients aged 4-18years were included if they received combined PSA with IN fentanyl and N2O for the reduction of mildly/moderately displaced fracture or of dislocation. Facial Pain Scale Revised (FPS-R) and Face, Leg, Activity, Cry, Consolability (FLACC) scores were used to evaluate pain and anxiety before, during and after procedure. University of Michigan Sedation Score (UMSS), adverse events, detailed side effects and satisfaction of patients, parents and medical staff were recorded at discharge. A follow up telephone call was made after 24-72h. RESULTS: 90 patients were included. There was no difference in FPS-R during the procedure (median score 2 versus 2), but the FLACC score was significantly higher as compared to before (median score 4 versus 0, Δ 2, 95% CI 0, 2). Median UMSS was 1 (95% CI 1, 2). We recorded no serious adverse events. Rate of vomiting was 12% (11/84). Satisfaction was high among participants responding to this question 85/88 (97%) of parents, 74/83 (89%) of patients and 82/85 (96%) of physicians would want the same sedation again. CONCLUSION: PSA with IN fentanyl and N2O is effective and safe for the reduction of mildly/moderately displaced fracture or dislocation, and has a high satisfaction rate.

In vivo dynamic compression has less detrimental effect than static compression on newly formed bone of a rat caudal vertebra.

Fusionless devices are currently designed to treat spinal deformities such as scoliosis by the application of a controlled mechanical loading. Growth modulation by dynamic compression was shown to preserve soft tissues. The objective of this in vivo study was to characterize the effect of static vs. dynamic loading on the bone formed during growth modulation. Controlled compression was applied during 15 days on the 7(th) caudal vertebra (Cd7) of rats during growth spurt. The load was sustained in the "static" group and sinusoidally oscillating in the "dynamic" group. The effect of surgery and of the device was investigated using control and sham (operated on but no load applied) groups. A high resolution CT-scan of Cd7 was acquired at days 2, 8 and 15 of compression. Growth rates, histomorphometric parameters and mineral density of the newly formed bone were quantified and compared. Static and dynamic loadings significantly reduced the growth rate by 20% compared to the sham group. Dynamic loading preserved newly formed bone histomorphometry and mineral density whereas static loading induced thicker (+31%) and more mineralized (+12%) trabeculae. A significant sham effect was observed. Growth modulation by dynamic compression constitutes a promising way to develop new treatment for skeletal deformities.

Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children.

BACKGROUND: Recent genome-wide association studies based on adult and paediatric populations have implicated >30 genes/loci as susceptibility loci for Crohn's disease (CD). AIMS: To investigate whether reported genes/loci were also associated with CD in Canadian children. DESIGN AND METHODS: A case-control design was implemented at three paediatric gastroenterology clinics in Canada. Children < or =18 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in five genome-wide association studies reported genes/loci were genotyped. Associations between individual SNPs and CD were examined. RESULTS: A total of 406 cases and 415 controls were studied. The mean (+/-s.d.) age of the cases was 12.3 (+/-3.2) years. Most cases were male (56.6%), had ileo-colonic disease (L3 +/- L4, 52.0%) and inflammatory behaviour (B1 +/- p, 86.9%) at diagnosis. Allelic association analysis (two-tailed) showed that three of the five targeted SNPs were significantly associated with overall susceptibility for CD (ZNF365, r10995271, P = 0.001; PTPN2, rs1893217, P = 0.005; STAT3, rs744166, P = 0.01). Associations with SNP rs4613763 in the PTGER4 locus were marginally nonsignificant (P = 0.07). The ZNF365 and STAT3 SNPs were predominantly associated with ileal disease with or without colonic involvement. CONCLUSION: The identified susceptibility genes/loci for adult-onset CD also confer risk for paediatric-onset CD.

[Molecular and genetic aspects of idiopathic scoliosis. Blood test for idiopathic scoliosis]. / Molekulare und genetische Aspekte der idiopathischen Skoliose. Bluttest bei idiopathischer Skoliose.

Spinal deformities, and particularly scoliosis, are the most frequent forms of orthopedic deformities in children and adolescents. About 1-6% of the population has scoliosis. This disorder leads to severe spinal deformities and predominantly affects adolescent girls.Although the multifactorial origin of adolescent idiopathic scoliosis (AIS) is broadly recognized, the genetic causes of AIS are still largely unknown. Our previous studies suggested a generalized dysfunction of melatonin transduction (the hormone that is primarily produced in the brain and epiphysis). In the meantime we have demonstrated that such a defect of signal transduction is caused by chemical alterations, which inactivate the function of the inhibitory G protein-coupled melatonin receptors. This discovery has led to the development of the first blood test to detect children without symptoms who are at risk of developing scoliosis. Since a single function (cellular reaction to melatonin) is determined, the unique advantage of this test is that it can be performed without knowledge of mutations in defective genes that could provoke the onset of AIS.

Interleukin 10 (IL-10) gene variants and susceptibility for paediatric onset Crohn's disease.

BACKGROUND: A recent genome-wide association study in adult patients with ulcerative colitis (UC) has implicated the interleukin 10 (IL-10) gene as an important candidate gene. Moreover, a UC-associated single nucleotide polymorphism (SNP) rs3024405 was also significantly associated with adult Crohn's disease (CD). AIMS: To examine whether IL-10-CD associations extended to paediatric-onset CD. METHODS: We implemented the case-control design at three paediatric gastroenterology clinics in Canada. CD patients (

A variability study of computerized sagittal spinopelvic radiologic measurements of trunk balance.

OBJECTIVE: The accurate measurement of spinal and pelvic alignment in the sagittal plane is of prime importance for various disorders. Pelvic incidence (PI) is a fundamental anatomic parameter that is specific and constant for each adult individual and is related to pelvic orientation as well as to the size of lumbar lordosis (LL). It is the summation of the sacral slope (SS) and pelvic tilt (PT), two position-dependent variables that determine pelvic orientation in the sagittal plane. The authors have proposed a computer software designed to measure PI, SS, PT, LL, and thoracic kyphosis (TK) on standardized standing lateral digitized x-rays of the spine and pelvis. The purpose of this study was to evaluate the inter- and intraobserver variability of measurements using this software, to determine if it can be used reliably in a clinical environment. METHODS: The standing lateral x-rays of 30 subjects were randomly selected from the database of two medical institutions. The normal population had standard radiographs on which the various pertinent landmarks were marked by one operator prior to digitization, whereas the scoliotic population had digital radiographs that obviated the need for prior marking of landmarks. Four individuals measured all variables on the 30 x-rays on two occasions, with a 15-day interval between the two sessions. Statistical analysis was done with intraclass correlation coefficients (ICCs). RESULTS: The ICC measured within observers was between 0.93 and 0.99, whereas the ICC between observers varied between 0.92 and 0.99. The variations observed were similar for normal and scoliotic subjects, and prior marking of the x-rays had no significant influence. CONCLUSION: We conclude that the variability of measurements with this method is lower than with similar radiologic measures done manually and that the use of this software can be recommended for future clinical and research studies of spinopelvic sagittal balance.

Evolution of 3D deformities in adolescents with progressive idiopathic scoliosis.

The objective of this study was to conduct an intrasubject longitudinal study quantifying the evolution of two- and three-dimensional geometrical scoliotic descriptors. The evolution of regional and local scoliotic descriptors was analyzed between two scoliotic visits on a cohort of 28 adolescents with progressive idiopathic scoliosis. Mean age at the first visit was 12.7 +/- 1.7 years old and averaged time interval between two assessments reached 22.8 +/- 10.8 months. Scoliotic descriptors were obtained from three-dimensionally reconstructed spines. The initial thoracic Cobb angle was on average 35.3 degrees +/- 8.4 degrees (range, 14 degrees-54 degrees). The evolution of spinal curvatures and vertebral deformities was assessed statistically in terms of descriptor absolute variations, and of descriptor variations normalized with respect to time and to the increase in Cobb angle. At the thoracic level, vertebral wedging increased with curve severity in a relatively consistent pattern for most scoliotic patients and axial rotation mainly increased towards curve convexity with scoliosis severity. No consistent evolution was associated with the angular orientation of the maximum wedging. Thoracic kyphosis changes (increase and decrease) were observed in important proportions. Results of this study challenge the existence of a typical scoliotic evolution pattern and suggest that the scoliotic evolution is quite variable and patient-specific.

Progression of vertebral and spinal three-dimensional deformities in adolescent idiopathic scoliosis: a longitudinal study.

STUDY DESIGN: The evolution of scoliotic descriptors was analyzed from three-dimensionally reconstructed spines and assessed statistically in a group of adolescents with progressive idiopathic scoliosis. OBJECTIVES: To conduct an intrasubject longitudinal study quantifying evolution of two- and three-dimensional geometrical descriptors characterizing the scoliotic spine and vertebral deformities. SUMMARY OF BACKGROUND DATA: The data available on geometric descriptors usually are based on cross-sectional studies comparing scoliotic configurations of different individuals. The literature reports very few longitudinal studies that evaluated different phases of scoliotic progression in the same patients. METHODS: The evolution of regional and local descriptors between two scoliotic visits was analyzed in 28 adolescents with scoliosis. Several statistical analyses were performed to determine how spinal curvatures and vertebral deformities change during scoliosis progression. RESULTS: At the thoracic level, vertebral wedging increases with curve severity in a relatively consistent pattern for most patients with scoliosis. Axial rotation mainly increases toward curve convexity with scoliosis severity, worsening the progression of vertebral body deformities. No consistent evolution is associated with the angular orientation of the maximum wedging. Thoracic kyphosis varies considerably among subjects. Both increasing and decreasing kyphosis are observed in nonnegligible proportions. A decrease in kyphosis is associated with a shift in the plane of maximum deformity toward the frontal plane, which worsens the three-dimensional shape of the spine. CONCLUSIONS: The results of this study challenge the existence of a typical scoliotic evolution pattern and suggest that scoliotic evolution is quite variable and patient specific.

[Treatment of diaphyseal femoral fractures in children: a clinical study]. / Traitement des fractures diaphysaires du fémur chez l'enfant: un essai clinique.

UNLABELLED: Many therapeutic modalities have been reported for the management of femoral shaft fractures in children and young adolescents but there is no consensus on the preferable method. PURPOSE: To compare the malunion rate of femoral shaft fractures in children treated either by traction and spica cast or traction and functional brace. MATERIAL AND METHODS: Between 1982 and 1984 a prospective study was carried out in a tertiary pediatric university hospital on 43 patients (24 boys, 19 girls) with a closed femoral shaft fracture. The patient's age ranged from 5 to 13 years old. Open, pathologic, subtrochanteric and physeal fractures were excluded. Fifteen (15) patients were treated by a functional brace and 28 were treated by a spica cast. Clinical and radiological assessments of all patients were performed 5 years or more after the fracture by an independent observer. A malunion occurred if one of these criteria were met: an angulation > or = 10 degrees in the coronal plane, an angulation > or = 15 degrees in the sagittal plane, a malrotation > or = 15 degrees by opposition to the other leg, and a discrepancy > or = 10 mm between femur's length. RESULTS: A malunion was found in 17 patients, 6 in the functional brace and 11 in the spica cast group (p > 0.05). The leg length discrepancy was the most common type of malunion. The length of stay was not significantly different between both treatment groups. The functional brace was worn longer than the spica cast. CONCLUSION: There was no statistical difference between the malunion rate of children treated by traction-spica cast and traction-functional brace. The functional brace appears to be a good alternative for the treatment for femoral shaft fracture in children allowing an earlier ambulation than spica cast.

Risk factors associated with alpine skiing injuries in children. A case-control study.

We investigated the relative contribution of four risk factors to the occurrence of injuries among alpine skiers aged 12 years and younger (3 to 12 years old; mean age, 9.43 years). The risk factors selected were deficient binding adjustment, absence of formal training, low skill level, and use of rented equipment. A group of injured skiers (N = 41) and a control group of uninjured skiers (N = 313) were recruited among young skiers at one major alpine ski center in the Quebec City, Canada, area during the 1995 to 1996 season. No significant group differences were found for mean age or sex distribution. The adjusted odds ratios for injury were 7.54 (95% confidence interval [2.57, 22.15]) for skiers in the low level of skill category relative to highly skilled skiers, 7.14 (2.59, 19.87) for skiers who rented their ski equipment compared with skiers who owned their equipment, and 2.11 (1.02, 4.33) for skiers with ill-adjusted bindings compared with skiers with better-adjusted bindings. Only formal training did not meet the 0.05 significance level for entry into the model; this is probably because of methodologic limitations. Implications of these results for the development of a prevention program aimed at young skiers are discussed.

Open fractures of the tibia in children.

Ninety open fractures of the tibia treated at the authors' institution between 1985 and 1994 were retrospectively reviewed. There were 38 Grade I, 35 Grade II, and 17 Grade III fractures. All patients had debridement and lavage of the wound under general anesthesia. Seventeen wounds (19.8%) were closed primarily and 69 (80.2%) were left open. Forty fractures (45.0%) were stabilized in casts, 31 (34.8%) in an external fixator, and 18 (20.2%) with casts and internal fixation. Six patients (7.1%) had superficial infection occur, 2 had vascular injuries, 1 of whom required an amputation, and only 1 had a neurologic injury. The average time to union was 4.5 months (range, 1.2-28.3 months). there were 10 delayed and 7 nonunions. Multiple regression analysis showed that only age of the patient and grade of the fracture were significantly associated with union time. Open fractures of the tibia in children older than 12 years of age have a high risk of developing delayed or nonunion when compared with the same injuries in children younger than 6 years of age.

Rates of transcervical and pertrochanteric hip fractures in the province of Quebec, Canada, 1981-1992.

Two distinct subtypes of hip fracture, transcervical and pertrochanteric, can be distinguished on the basis of the anatomical location of the injury. While the epidemiology of hip fractures has been well described, typically, little or no distinction is made between these subtypes. The objective of this study was to compare and contrast age- and sex-specific rates of transcervical and pertrochanteric fractures in Quebec, Canada. The data for this study were obtained from a database containing records of all persons discharged from all hospitals in Quebec from 1981 to 1992. Rates of hip fractures were calculated by using the population aged 50 years and older as the denominator, and changes in rates over time were assessed using Poisson regression. There were no statistically significant trends in the changes in rates over time (i.e., 95 percent confidence intervals overlapped the null value). Among women below age 70 years, transcervical fractures were more common, whereas among older women, pertrochanteric fractures predominated. Among men, pertrochanteric fractures predominated at all ages. There was a marked seasonal variation in the occurrence of all hip fractures combined: Compared with the summer months, the relative risk of all hip fractures during the winter was 1.32 (95 percent confidence interval 1.28-1.36). The results of this study indicate that the two subtypes of hip fracture, transcervical and pertrochanteric, have different patterns of occurrence, suggesting different risk factor profiles. Clearly, a multidisciplinary research approach is needed before it will be possible to untangle the complex relation between the metabolic processes occurring at the level of the individual and the distribution of the disease in the population.

Head injuries in helmeted child bicyclists.

OBJECTIVE: To determine the characteristics and the severity of head and facial injuries to helmeted child bicyclists, and whether the helmet contributed to the injury, and to study factors related to bicycle accidents. DESIGN: Retrospective review of two case series. Children sustaining head injury while not wearing helmets were studied as a form of reference group. SETTING: Large paediatric teaching hospital. SUBJECTS: 34 helmeted child bicyclists and 155 non-helmeted bicyclists, aged 5-14 years. MAIN OUTCOME MEASURES: Number of injuries, type of injuries, injury severity score, deaths, and accident circumstances. RESULTS: 79% of the head injuries of the helmeted child group were mild and two thirds of these had facial injuries. Children in the helmet group were in a greater proportion of bike-car collisions than the no helmet group and at least 15% of the helmets were lost on impact. There were no injuries secondary to the helmet. CONCLUSIONS: Most of the head injuries sustained by the helmeted children were of mild severity and there was no evidence to suggest that the helmet contributed to injury. Nevertheless, consideration should be given to designing a facial protector for the bicycle helmet and to improvement of the fastening device.

Diurnal variation of Cobb angle measurement in adolescent idiopathic scoliosis.

To investigate the possible influence of gravity on daily variations of curve magnitude in adolescent idiopathic scoliosis, standardized anteroposterior standing radiographs of the spine were taken at 8:00 AM and repeated in the same conditions at 8:00 PM on the same day, 19 girls with idiopathic scoliosis, aged 10-16 years were included. The Cobb angle of the primary thoracic curve was measured blindly by four skilled orthopaedic surgeons. The mean interobserver variation in measuring Cobb angles on the 38 radiographs was 1.6 degrees. The average Cobb angle on morning radiographs was 60 degrees (range, 42-91 degrees) as compared to 65 degrees (range, 47-89 degrees) in the afternoon, a significant (P < 0.001) difference using a paired two-sided Student t test. It was concluded that there is a statistically and clinically significant daily increase of curve severity in moderate to severe idiopathic scoliosis.