Subject(s)
Fusion Proteins, bcr-abl/genetics , Janus Kinase 2/genetics , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics , Mutation , Myeloproliferative Disorders/genetics , Adult , Chronic Disease , Clone Cells , Female , Humans , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology , Male , Middle Aged , Myeloproliferative Disorders/pathologySubject(s)
Bone Marrow Cells , Urticaria Pigmentosa/pathology , Female , Humans , Ilium , Male , Mast Cells , SternumABSTRACT
The combination of aplastic anaemia and thymona was observed in a 49-year old woman. Concomitant with severe normochromic anaemia and reticulocytopenia was a cell-rich bone marrow smear in which erythropoietic precursors were almost absent. Immunological phenomena could not be demonstrated. The erythropoietin level was maximally increased. Pathological anatomy typically revealed a predominantly spindle-cell thymonal with only minor capsular invasion.
Subject(s)
Anemia, Aplastic/complications , Thymoma/complications , Thymus Neoplasms/complications , Anemia, Aplastic/blood , Bone Marrow Examination , Erythrocyte Count , Erythropoietin/analysis , Female , Humans , Middle Aged , Reticulocytes , Thymoma/blood , Thymus Neoplasms/bloodABSTRACT
A patient with multiple myeloma died of an acute myeloid leukaemia 15 years after onset of the former. At time of diagnosis the 39 year-old-patient had bone marrow infiltration of maximally 32 plasma cells/100 white bone marrow cells, a paraprotein (IgG, light-chain type lambda), osteoporosis of late onset and occasional osteolysis. The long survival time, as well as the acute myeloid leukaemia, are probably due to the effective treatment, first with cyclophosphamide (198 g over four years), later melphalan (3000 mg over eight years).
