[The myocardial contractile function and central hemodynamics of patients with insulin-dependent diabetes mellitus during treatment]. / Sokratitel'naia funktsiia miokarda i tsentral'naia gemodinamika u bol'nykh insulinzavisimym sakharnym diabetom v protsesse lecheniia.

The results of echocardiographic investigation of 48 patients with type I diabetes mellitus (DM) were compared: 48 patients received routine therapy including diabetic management, insulin and vitamin therapy, 32 received this type of therapy plus a complex consisting of inosine, benphothiamine and pyridoxal phosphate. A considerable decrease in myocardial contractility and hemodynamic disorder were revealed against a background of DM decompensation in both groups of patients. Clinical improvement resulting from the use of the above complex showed good correlation with a positive course of echocardiographic values of myocardial contractility and pumping function. Elimination of myocardial insufficiency was accompanied by an increase in the stroke volume, ejection fraction, the rate of circulatory shortening of myocardial fibers, left ventricular mass, and a decrease in end diastolic and systolic volumes. The second type of therapy was well tolerated by the patients and made it possible to considerably lessen myocardial insufficiency and reduce a period of treatment in hospital as compared to routine therapy.

[Age differences in the state of hemodynamics in diabetes mellitus patients]. / Vozrastnye razlichiia sostoianiia gemodinamiki u bol'nykh sakharnym diabetom.

Age-related changes in hemodynamics assessed with the help of integral rheography were compared for two age groups of patients suffering from type I diabetes mellitus (DM). Twenty-three patients were under 40 (group 1) and twenty-five were over 40 (group 2). Age-related changes typical for central hemodynamics in health disappeared in decompensated DM and were not registered after DM compensation. More profound hemodynamic affections were recorded in group 1 patients who had probably impaired parasympathetic innervation of the heart.

[Central hemodynamics, effectiveness of endocardial blood flow and general physical work capacity in impaired glucose tolerance and diabetes mellitus]. / Tsentral'naia gemodinamika, effektivnost' endokardial'nogo krovotoka i obshchaia fizicheskaia rabotosposobnost' pri pri narushennoi tolerantnosti k gliukoze i sakharnom diabete.

The end diastolic pressure, myocardial viability index and other parameters of myocardial contractility, as well as central hemodynamics and general physical working capacity were studied in 120 subjects, including 20 subjects with impaired glucose tolerance, 80 patients with diabetes mellitus, and a control group of 20 healthy subjects. In impaired glucose tolerance, a tendency to reduced endocardial blood flow and myocardial contractility as well as elevated end diastolic pressure were observed. The physical working capacity remained within normal. In decompensated diabetes mellitus, the efficacy of endocardial blood flow considerably reduced, the end diastolic pressure rose more than twofold, myocardial contractility deteriorated, the stroke volume decreased, the general physical working capacity sharply fell. In compensated diabetes mellitus, versus decompensated one, subendocardial perfusion and myocardial contractility improved, stroke volume increased; the exercise tolerance threshold rose but did not reach normal.