[Effect of von Willebrand factor and endothelin-1 on formation of thrombotic status in patients with ischemic heart disease].

In 44 patients with ischemic heart disease (IHD) and 35 healthy subjects we studied cascade mechanism of platelets activation by von Willebrand factor (vWF), and interrelationship of platelet aggregation, level of vWF, and endothelial dysfunction. The latter was estimated by severity of vasoconstriction determined basing on endothelin-1 levels. Quantitative assessment of platelet aggregation revealed differences in aggregation capacity between healthy subjects and patients with IHD. Of particular importance was absence of spontaneous aggregation in healthy subjects. It was shown that in IHD patients influence of vWF resulted in augmentation and convergence of activating signal. Positive correlation was found in patients with IHD between elevation of levels of vWF, endothelin-1, and spontaneous and induced platelet aggregation activity. Interrelationship was revealed between character of IHD course and degree of elevation of the studied markers.

[Galavit-induced change of immunologic parameters in patients with non-small lung cancer].

Administration of an immunomodulator, galavit, for stage II-III non-small lung cancer along with standard therapy was followed by immunological vigor improvement by the end of the course. CD3, CD4, IgA, IgM and IgG indices were normal in more than 80% of the study group by day 51 after surgery; CD8, CD20 and HLA-DR--in more than 50%; CD16--in 45.2%. In control, by day 51, normal IgG and HLA-DR levels were reported in 60%. The remaining indices were normal in less than 50%. Our results point to immunological vigor improvement due to use of galavit. The drug is well tolerated, has neither side effects nor toxicity.

[Occupational bronchial asthma due to organic solvents]. / Professional'naia bronkhial'naia astma ot organicheskikh rastvoritelei.

Thorough clinical, allergologic and immunologic examination of 65 patients who worked as building painters in contact with organic solvents proved these agents, not being allergens, to contribute in formation of occupational bronchial asthma. This type of bronchial asthma is characterized by some clinical features and pathogenetic mechanisms. A complex of clinical, allergologic and immunologic methods was elaborated to diagnose this type of bronchial asthma.

[Food habits and work capacity indices of adolescents learning the specialties of locksmith and automobile mechanics]. / Fakticheskoe pitanie i pokazateli rabotosposobnosti podrostkov, osvaivaiushchikh spetsialnost slesaria- avtoremontnika.

Complex assessment of the pupils studied the metalworker of motorcar repair service. Profession was given in aspect of their diet. Some recommendations based on the assessment were worked out.

[Actual problems of allergy in occupational pathology]. / Aktualnye problemy allergii v professionalnoi patologii.

Data from different sources concerning the modern status of the allergy problem in the occupational pathology are represented. Features of immunologic pathogenesis in occupational respiratory tract diseases formation due to the simple and composite substances, protein denaturants, immune modulators and histamine-liberators organic and non-organic by origin are described. The most promising directions for the further investigation of the problem are stated and based.

[Basic achievements in the diagnosis and in the problems of the pathogenesis and clinical picture of respiratory organ diseases of dust etiology]. / Osnovnye dostizheniia v diagnostike, voprosakh patogeneza i kliniki zabolevanii organov dykhaniia pylevoi étiologii.

The article contains new data concerned with the respiratory pathologic processes caused by industrial aerosols of different compositions, as well as the mechanisms of their functioning and development. Current problems of occupational lung diseases' treatment are considered in this connection.

[A biochemical assessment of the glucocorticoid function of the adrenal cortex in patients with occupational bronchial asthma and asthmatic bronchitis]. / Biokhimicheskaia otsenka gliukokortikoidnoi funktsii kory nadpochechnikov u bol'nykh professional'noi bronkhial'noi astmoi i astmaticheskim bronkhitom.

The article contains a study of the basal level and the circadian rhythm of the hydrocortisone secretion in patients with occupational bronchial asthma and asthmatic bronchitis. Relationships were established between the hydrocortisone secretion levels and severity of the clinical course. Circadian rythm disorders resulted into double hydrocortisone secretion increases at 8 a.m. and 11 p.m. Hydrocortisone secretion circadian rhythm data should be taken into account in the development of individual therapies.

[Mechanisms of the development of immunodependent inflammation in silicosis]. / Mekhanizmy razvitiia immunozavisimogo vospaleniia pri silikoze.

Patients with uncomplicated silicosis were found to develop chronic immunodependent inflammation caused by an adjuvant effect of silica and characterized by autoimmune, histamine- and complement-dependent components. Reduced specific and non-specific antimicrobial defence underlies frequent complication of silicosis by tuberculosis and nonspecific infectious diseases of the bronchopulmonary system. A diagram showing the development of immunodependent inflammation in silicosis is presented.

[Histamine-related reactions in patients with byssinosis]. / Gistaminzavisimnye reaktsii u bol'nykh bissinozom.

The purpose of the study was to analyze the mechanism of histamine action in histamine-dependent reactions of neutrophils and lymphocytes in patients with byssinosis and chronic asthmatic bronchitis under cotton and flax dust effect. The appraisal of histamine content in blood serum, receptor/histamine distribution of lymphocyte and neutrophil subpopulations (rosette-forming double and triple reactions), determination of histamine modeling effect on lymphocyte-neutrophil cooperation in the inhibition reaction of leukocyte migration revealed that under cotton dust effect neutrophils and the complement system were involved into the histamine liberation process in byssinosis patients, lymphocytes were most likely not involved into the process. Flax dust-affected histamine reactions were not so distinct: lymphocyte and neutrophil reactivity in byssinosis patients did not exceed the standards. Patients with chronic asthmatic bronchitis had high blood concentration of histamine and experienced some changes in cells' migration characteristics. It was assumed that primarily nonimmune mechanisms of histamine liberation and activation of the complement system were involved into byssinosis pathological process in patients exposed to cotton and flax dust effect. In patients with chronic asthmatic bronchitis there occurred all 3 activation mechanisms of biologically active substances, i.e., allergic and nonantigenic ways of histamine liberation and activation of the complement system.