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Gematol Transfuziol ; 35(7): 25-8, 1990 Jul.
Article in Russian | MEDLINE | ID: mdl-2210320

ABSTRACT

Acute experimental hepatitis was induced by a single injection of 1% water solution of allyl spirit in a dose of 100 mg/kg. Morphofunctional state of peripheral blood and bone marrow cells was studied with the use of hematological and cytochemical methods. Specific changes were detected in the peripheral blood and bone marrow cell parameters in the early (6 and 12 h) and late (24h--10 days) periods after the injection. Changes in the liver and in the blood and bone marrow cells were irreversible. Most of the parameters studied returned to normal 22 days after the injection of allyl spirit.


Subject(s)
Blood Cells/pathology , Bone Marrow/pathology , Disease Models, Animal , Hematopoietic Stem Cells/pathology , Hepatitis, Animal/blood , Acute Disease , Animals , Blood Cell Count/drug effects , Blood Cells/drug effects , Blood Cells/metabolism , Hematopoietic Stem Cells/drug effects , Hematopoietic Stem Cells/metabolism , Hepatitis, Animal/chemically induced , Hepatitis, Animal/pathology , Male , Propanols , Rats , Rats, Inbred Strains
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