ABSTRACT
A possibility to use immunostimulator dibasole and methyluracil to increase [correction of decrease] the level of neutralising antibodies to polioviruses [correction of polyviruses] of types I, II, III in response to immunization by the alive poliomyelitis vaccine was studied in experiments on rabbits. The higher level of immune response when using the mentioned drugs, especially methyluracil, has been established; repeated immunization is needed to develop antibodies to poliovirus [correction of polyavirus] of type III.
Subject(s)
Adjuvants, Immunologic/pharmacology , Benzimidazoles/pharmacology , Poliomyelitis/prevention & control , Poliovirus Vaccine, Oral/immunology , Uracil/analogs & derivatives , Animals , Antibodies, Viral/blood , Antibodies, Viral/drug effects , Immunity/drug effects , Immunization/methods , Neutralization Tests , Poliovirus/immunology , Rabbits , Time Factors , Uracil/pharmacology , Vaccines, Attenuated/immunologyABSTRACT
The studies of the therapeutic and prophylactic action of a compound from the group of nonsteroid antiinflammatory substances, iodantipyrine-4, in newborn white mice infected with Coxsackie B3 virus showed the drug to possess both therapeutic and prophylactic activity in the acute period of infection.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Antipyrine/analogs & derivatives , Antiviral Agents/therapeutic use , Coxsackievirus Infections/drug therapy , Enterovirus B, Human , Animals , Antipyrine/therapeutic use , Coxsackievirus Infections/microbiology , Coxsackievirus Infections/mortality , Coxsackievirus Infections/pathology , Disease Models, Animal , Drug Evaluation, Preclinical , Enterovirus B, Human/isolation & purification , Mice , Myocardium/pathology , Pancreas/pathology , Time FactorsABSTRACT
The antiviral activity of iodantipyrine-4 belonging to the group of nonsteroid anti-inflammatory compounds was studied in inbred white mice of 10-12 g given a single subcutaneous injection of the Absettarov strain of tick-borne encephalitis virus. Iodantipyrine-4 in different doses was administered orally or parenterally, and the animals were observed for 21 days. In the group of mice infected with 10 LD50 of TBE virus which were treated with the drug orally in a dose of 50 mg/kg a reliable therapeutic effect was established in 60%, after parenteral injection in 53.4%. Prophylactic administration of the drug followed by challenge with 10 LD50 of virus was effective in 47% of mice. In the group of mice infected with 100 LD50 of the virus the therapeutic effect was observed in 38% and prophylactic in 30%. Iodantipyrine-4 was found to induce interferon production.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Antipyrine/analogs & derivatives , Antiviral Agents/therapeutic use , Encephalitis, Tick-Borne/drug therapy , Administration, Oral , Animals , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Antipyrine/administration & dosage , Antipyrine/therapeutic use , Antiviral Agents/administration & dosage , Dipyridamole/administration & dosage , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Encephalitis, Tick-Borne/blood , Encephalitis, Tick-Borne/prevention & control , Injections, Intraperitoneal , Interferon Inducers/administration & dosage , Interferon Inducers/therapeutic use , Interferon-alpha/blood , Male , MiceABSTRACT
An immunostimulating effect of PIF was studied. The augmentation of antibody production to Coxsackie A13 virus as well as protective effect during influenza infection have been found out in mice after PIF injections. An immunostimulating effect of PIF after SRBC immunization of mice has been also revealed. Possible mechanisms of immunostimulating effect of PIF are discussed.
Subject(s)
Adjuvants, Immunologic , Antibodies, Viral/analysis , Antibody Formation , Lymphokines/pharmacology , Animals , Enterovirus/immunology , Influenza A virus/immunology , Lymphokines/administration & dosage , Male , Mice , Mice, Inbred BALB CABSTRACT
There has been studied the influence of a number of nonsteroidal antiinflammatory agents (NSAID ) on the humoral immune response of mice in immunization with erythrocytic and viral antigen. It has been found out that NSAID have immunomodulating effect, stimulating humoral immune response (4-iodantipyrine, 4-bromantipyrine) or suppressing it (butadione, sodium salicylate). Apparently the mechanism of NSAID ++ immunostimulating effect is related to the inhibition of T-suppressors ++ function by the latter ones.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Antibody-Producing Cells/cytology , Antigens, Heterophile/immunology , Antigens, Viral/immunology , Enterovirus/immunology , Spleen/cytology , T-Lymphocytes/immunology , Adjuvants, Immunologic , Animals , Antibody-Producing Cells/drug effects , In Vitro Techniques , Mice , Sheep , Spleen/drug effects , T-Lymphocytes/drug effectsABSTRACT
Nonsteroid antiinflammatory agents (NAIA) such as antipyrine, butadion, acetylsalicylic acid, sodium salicylate, stampyrine and 4-iodantipyrine are not interferonogenic. Still, they stimulated interferonogenic action of poly(G).poly(C) in studies on animals. Relation between the interferon-stimulating action of the NAIA and their effect on activity of prostaglandin and the influence on the immune system was suggested.
