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1.
Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution.
Kosloff, Mickey; Han, Gye Won; Krishna, S Sri; Schwarzenbacher, Robert; Fasnacht, Marc; Elsliger, Marc-André; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Astakhova, Tamara; Axelrod, Herbert L; Canaves, Jaume M; Carlton, Dennis; Chiu, Hsiu-Ju; Clayton, Thomas; DiDonato, Michael; Duan, Lian; Feuerhelm, Julie; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Haugen, Justin; Jaroszewski, Lukasz; Jin, Kevin K; Johnson, Hope; Klock, Heath E; Knuth, Mark W; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Levin, Inna; McMullan, Daniel; Miller, Mitchell D; Morse, Andrew T; Moy, Kin; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Page, Rebecca; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Christopher L; Sims, Eric; Spraggon, Glen; Sridhar, Vandana; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff.
Proteins ; 65(3): 527-37, 2006 Nov 15.
Article in English | MEDLINE | ID: mdl-16988933

ABSTRACT

Glutathione S-transferases (GSTs) comprise a diverse superfamily of enzymes found in organisms from all kingdoms of life. GSTs are involved in diverse processes, notably small-molecule biosynthesis or detoxification, and are frequently also used in protein engineering studies or as biotechnology tools. Here, we report the high-resolution X-ray structure of Atu5508 from the pathogenic soil bacterium Agrobacterium tumefaciens (atGST1). Through use of comparative sequence and structural analysis of the GST superfamily, we identified local sequence and structural signatures, which allowed us to distinguish between different GST classes. This approach enables GST classification based on structure, without requiring additional biochemical or immunological data. Consequently, analysis of the atGST1 crystal structure suggests a new GST class, distinct from previously characterized GSTs, which would make it an attractive target for further biochemical studies.


Subject(s)
Agrobacterium tumefaciens/enzymology , Bacterial Proteins/chemistry , Glutathione Transferase/chemistry , Agrobacterium tumefaciens/chemistry , Agrobacterium tumefaciens/cytology , Amino Acid Sequence , Bacterial Proteins/classification , Crystallography, X-Ray , Dimerization , Glutathione Transferase/classification , Models, Molecular , Molecular Sequence Data , Phylogeny , Protein Structure, Secondary
2.
Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution.
Xu, Qingping; Schwarzenbacher, Robert; Krishna, S Sri; McMullan, Daniel; Agarwalla, Sanjay; Quijano, Kevin; Abdubek, Polat; Ambing, Eileen; Axelrod, Herbert; Biorac, Tanya; Canaves, Jaume M; Chiu, Hsiu-Ju; Elsliger, Marc-André; Grittini, Carina; Grzechnik, Slawomir K; DiDonato, Michael; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Hornsby, Michael; Jaroszewski, Lukasz; Klock, Heath E; Knuth, Mark W; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Miller, Mitchell D; Moy, Kin; Nigoghossian, Edward; Paulsen, Jessica; Reyes, Ron; Rife, Chris; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; White, Aprilfawn; Wolf, Guenter; Hodgson, Keith O; Wooley, John; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Wilson, Ian A.
Proteins ; 64(3): 808-13, 2006 Aug 15.
Article in English | MEDLINE | ID: mdl-16783794

Subject(s)
Dioxygenases/chemistry , Amino Acid Sequence , Animals , Binding Sites , Crystallization , Databases, Protein , Dioxygenases/genetics , Dioxygenases/metabolism , Metals/chemistry , Mice , Models, Molecular , Molecular Sequence Data , Molecular Structure , Protein Binding , Protein Structure, Secondary , Protein Structure, Tertiary
3.
Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold.
Jin, Kevin Kai; Krishna, S Sri; Schwarzenbacher, Robert; McMullan, Daniel; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Axelrod, Herbert; Canaves, Jaume M; Chiu, Hsiu-Ju; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Feuerhelm, Julie; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Haugen, Justin; Hornsby, Michael; Jaroszewski, Lukasz; Klock, Heath E; Knuth, Mark W; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; Miller, Mitchell D; Moy, Kin; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Chris; Stevens, Raymond C; Spraggon, Glen; van den Bedem, Henry; Velasquez, Jeff; White, Aprilfawn; Wolf, Guenter; Han, Gye Won; Xu, Qingping; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 63(4): 1112-8, 2006 Jun 01.
Article in English | MEDLINE | ID: mdl-16544291

Subject(s)
Bacterial Proteins/chemistry , Bacterial Proteins/metabolism , Cyclophilins/chemistry , Cyclophilins/metabolism , Peptidylprolyl Isomerase/chemistry , Peptidylprolyl Isomerase/metabolism , Thermotoga maritima/enzymology , Amino Acid Sequence , Bacterial Proteins/genetics , Binding Sites , Crystallography, X-Ray , Humans , Models, Molecular , Molecular Sequence Data , Peptidylprolyl Isomerase/classification , Polyethylene Glycols , Protein Folding , Protein Structure, Quaternary , Protein Structure, Tertiary
4.
Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution.
Mathews, Irimpan I; Krishna, S Sri; Schwarzenbacher, Robert; McMullan, Daniel; Abdubek, Polat; Ambing, Eileen; Canaves, Jaume M; Chiu, Hsiu-Ju; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Jaroszewski, Lukasz; Klock, Heath E; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; Levin, Inna; Miller, Mitchell D; Moy, Kin; Nigoghossian, Edward; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 63(4): 1106-11, 2006 Jun 01.
Article in English | MEDLINE | ID: mdl-16544324

Subject(s)
Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/chemistry , Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/metabolism , Thermotoga maritima/enzymology , Amino Acid Sequence , Binding Sites , Crystallography, X-Ray , Models, Molecular , Molecular Sequence Data , Protein Structure, Quaternary , Protein Structure, Tertiary , Structural Homology, Protein
5.
Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 A resolution.
DiDonato, Michael; Krishna, S Sri; Schwarzenbacher, Robert; McMullan, Daniel; Jaroszewski, Lukasz; Miller, Mitchell D; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Axelrod, Herbert; Biorac, Tanya; Chiu, Hsiu-Ju; Deacon, Ashley M; Elsliger, Marc-André; Feuerhelm, Julie; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Haugen, Justin; Hornsby, Michael; Klock, Heath E; Knuth, Mark W; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; Moy, Kin; Nigoghossian, Edward; Okach, Linda; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Chris; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 63(1): 256-60, 2006 Apr 01.
Article in English | MEDLINE | ID: mdl-16435371

Subject(s)
DNA-Binding Proteins/chemistry , Thermotoga maritima/metabolism , Amino Acid Sequence , Anisotropy , Crystallography, X-Ray , DNA, Single-Stranded , Escherichia coli/metabolism , Mitochondria/metabolism , Models, Molecular , Molecular Sequence Data , Plasmids/metabolism , Protein Structure, Secondary , Transcription Factors/chemistry , X-Ray Diffraction
6.
Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 A resolution reveals a new fold.
Xu, Qingping; Schwarzenbacher, Robert; McMullan, Daniel; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Axelrod, Herbert; Biorac, Tanya; Canaves, Jaume M; Chiu, Hsiu-Ju; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Hornsby, Michael; Jaroszewski, Lukasz; Klock, Heath E; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; Miller, Mitchell D; Moy, Kin; Nigoghossian, Edward; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Chris; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; White, Aprilfawn; Wolf, Guenter; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 62(1): 292-6, 2006 Jan 01.
Article in English | MEDLINE | ID: mdl-16287129

Subject(s)
Bacterial Proteins/chemistry , Campylobacter jejuni/pathogenicity , Virulence Factors/chemistry , Bacterial Proteins/metabolism , Crystallography, X-Ray , Models, Molecular , Protein Folding , Protein Structure, Secondary , Virulence Factors/metabolism
7.
Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 A resolution reveals a new fold.
Klock, Heath E; Schwarzenbacher, Robert; Xu, Qingping; McMullan, Daniel; Abdubek, Polat; Ambing, Eileen; Axelrod, Herbert; Biorac, Tanya; Canaves, Jaume M; Chiu, Hsiu-Ju; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Hornsby, Michael; Jaroszewski, Lukasz; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Miller, Mitchell D; Moy, Kin; Nigoghossian, Edward; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Chris; Sims, Eric; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Vincent, Juli; White, Aprilfawn; Wolf, Guenter; Hodgson, Keith O; Wooley, John; Lesley, Scott A; Wilson, Ian A.
Proteins ; 61(4): 1132-6, 2005 Dec 01.
Article in English | MEDLINE | ID: mdl-16224779

Subject(s)
Databases, Protein , Proteins/chemistry , Animals , Conserved Sequence , Crystallography, X-Ray , Mice , Models, Molecular , Molecular Weight , Open Reading Frames , Protein Folding , Protein Structure, Secondary
8.
Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20 A resolution.
Jaroszewski, Lukasz; Schwarzenbacher, Robert; McMullan, Daniel; Abdubek, Polat; Agarwalla, Sanjay; Ambing, Eileen; Axelrod, Herbert; Biorac, Tanya; Canaves, Jaume M; Chiu, Hsiu-Ju; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Hornsby, Michael; Klock, Heath E; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; Miller, Mitchell D; Moy, Kin; Nigoghossian, Edward; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Rife, Chris; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Vincent, Juli; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 61(3): 669-73, 2005 Nov 15.
Article in English | MEDLINE | ID: mdl-16167343

Subject(s)
Bacterial Proteins/chemistry , Heat-Shock Proteins/chemistry , Molecular Chaperones/chemistry , Thermotoga maritima/chemistry , Amino Acid Sequence , Crystallization , Molecular Sequence Data , Zinc Fingers
9.
Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 A resolution reveals a new fold.
Rife, Chris; Schwarzenbacher, Robert; McMullan, Daniel; Abdubek, Polat; Ambing, Eileen; Axelrod, Herbert; Biorac, Tanya; Canaves, Jaume M; Chiu, Hsiu-Ju; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Hornsby, Michael; Jaroszewski, Lukasz; Klock, Heath E; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; Miller, Mitchell D; Moy, Kin; Nigoghossian, Edward; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Sims, Eric; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Vincent, Juli; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 61(2): 449-53, 2005 Nov 01.
Article in English | MEDLINE | ID: mdl-16104018

Subject(s)
Bacterial Proteins/chemistry , Models, Molecular , Pseudomonas putida , RNA-Binding Proteins/chemistry , Amino Acid Sequence , Crystallography, X-Ray , Dimerization , Molecular Sequence Data , Protein Folding
10.
Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold.
Rife, Chris; Schwarzenbacher, Robert; McMullan, Daniel; Abdubek, Polat; Ambing, Eileen; Axelrod, Herbert; Biorac, Tanya; Canaves, Jaume M; Chiu, Hsiu-Ju; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Hornsby, Michael; Jaroszewski, Lukasz; Klock, Heath E; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; Miller, Mitchell D; Moy, Kin; Nigoghossian, Edward; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Sims, Eric; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Vincent, Juli; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 61(2): 444-8, 2005 Nov 01.
Article in English | MEDLINE | ID: mdl-16104019

Subject(s)
Bacterial Proteins/chemistry , Models, Molecular , Thermotoga maritima , Amino Acid Sequence , Crystallography, X-Ray , DNA Gyrase/metabolism , Dimerization , Molecular Sequence Data , Protein Folding , Thermotoga maritima/enzymology
11.
Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution.
Han, Gye Won; Schwarzenbacher, Robert; McMullan, Daniel; Abdubek, Polat; Ambing, Eileen; Axelrod, Herbert; Biorac, Tanya; Canaves, Jaume M; Chiu, Hsiu-Ju; Dai, Xiaoping; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Haugen, Justin; Hornsby, Michael; Jaroszewski, Lukasz; Klock, Heath E; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; McPhillips, Timothy M; Miller, Mitchell D; Moy, Kin; Nigoghossian, Edward; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Vincent, Juli; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 60(4): 797-802, 2005 Sep 01.
Article in English | MEDLINE | ID: mdl-16001405

Subject(s)
Apoenzymes/chemistry , Endoribonucleases/chemistry , RNA, Messenger/metabolism , Amino Acid Sequence , Animals , Crystallography, X-Ray , Mice , Models, Molecular , Molecular Sequence Data , Protein Structure, Secondary , Sensitivity and Specificity
12.
Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 A resolution reveals a new fold.
Levin, Inna; Miller, Mitchell D; Schwarzenbacher, Robert; McMullan, Daniel; Abdubek, Polat; Ambing, Eileen; Biorac, Tanya; Cambell, Jamison; Canaves, Jaume M; Chiu, Hsiu-Ju; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Hornsby, Michael; Jaroszewski, Lukasz; Karlak, Cathy; Klock, Heath E; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; Morse, Andrew; Moy, Kin; Nigoghossian, Edward; Ouyang, Jie; Page, Rebecca; Quijano, Kevin; Reyes, Ron; Robb, Alyssa; Sims, Eric; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Vincent, Juli; Wang, Xianhong; West, Bill; Wolf, Guenter; Xu, Qingping; Zagnitko, Olga; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 59(4): 864-8, 2005 Jun 01.
Article in English | MEDLINE | ID: mdl-15822122

Subject(s)
Bacterial Proteins/chemistry , Thermotoga maritima/enzymology , Bacterial Proteins/metabolism , Crystallography, X-Ray , Models, Molecular , Piperidones/metabolism , Protein Conformation , Protein Folding
13.
Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold.
Mathews, Irimpan; Schwarzenbacher, Robert; McMullan, Daniel; Abdubek, Polat; Ambing, Eileen; Axelrod, Herbert; Biorac, Tanya; Canaves, Jaume M; Chiu, Hsiu-Ju; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Hornsby, Michael; Jaroszewski, Lukasz; Klock, Heath E; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; Levin, Inna; Miller, Mitchell D; Moy, Kin; Nigoghossian, Edward; Ouyang, Jie; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Vincent, Juli; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 59(4): 869-74, 2005 Jun 01.
Article in English | MEDLINE | ID: mdl-15822125

Subject(s)
Isomerases/chemistry , Protein Folding , Thermotoga maritima/enzymology , Crystallography, X-Ray/methods , Isomerases/metabolism , Ligands , Models, Molecular , Protein Conformation , Solvents
14.
Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold.
Xu, Qingping; Schwarzenbacher, Robert; McMullan, Daniel; Abdubek, Polat; Ambing, Eileen; Biorac, Tanya; Canaves, Jaume M; Chiu, Hsiu-Ju; Dai, Xiaoping; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hampton, Eric; Hornsby, Michael; Jaroszewski, Lukasz; Klock, Heath E; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; Levin, Inna; Miller, Mitchell D; Morse, Andrew; Moy, Kin; Ouyang, Jie; Page, Rebecca; Quijano, Kevin; Reyes, Ron; Robb, Alyssa; Sims, Eric; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Vincent, Juli; von Delft, Frank; Wang, Xianhong; West, Bill; White, Aprilfawn; Wolf, Guenter; Zagnitko, Olga; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 58(4): 976-81, 2005 Mar 01.
Article in English | MEDLINE | ID: mdl-15651027

Subject(s)
Ammonia-Lyases/chemistry , Thermotoga maritima/enzymology , Amino Acid Sequence , Binding Sites , Crystallization , Crystallography, X-Ray , Enzyme Stability , Models, Chemical , Models, Molecular , Molecular Conformation , Molecular Sequence Data , Protein Conformation , Protein Structure, Secondary , Protein Structure, Tertiary
15.
Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor.
Han, Gye Won; Schwarzenbacher, Robert; Page, Rebecca; Jaroszewski, Lukasz; Abdubek, Polat; Ambing, Eileen; Biorac, Tanya; Canaves, Jaume M; Chiu, Hsiu-Ju; Dai, Xiaoping; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Haugen, Justin; Hornsby, Michael; Klock, Heath E; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; Levin, Inna; McMullan, Daniel; McPhillips, Timothy M; Miller, Mitchell D; Morse, Andrew; Moy, Kin; Nigoghossian, Edward; Ouyang, Jie; Paulsen, Jessica; Quijano, Kevin; Reyes, Ron; Sims, Eric; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Vincent, Juli; von Delft, Frank; Wang, Xianhong; West, Bill; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Zagnitko, Olga; Hodgson, Keith O.
Proteins ; 58(4): 971-5, 2005 Mar 01.
Article in English | MEDLINE | ID: mdl-15657930

Subject(s)
Anabaena/enzymology , Proteins/chemistry , Transaminases/chemistry , Amino Acid Sequence , Crystallography, X-Ray , Electrons , Humans , Models, Molecular , Molecular Sequence Data , Protein Conformation , Protein Structure, Tertiary , Sequence Homology, Amino Acid , Stereoisomerism
16.
Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution.
Arndt, Joseph W; Schwarzenbacher, Robert; Page, Rebecca; Abdubek, Polat; Ambing, Eileen; Biorac, Tanya; Canaves, Jaume M; Chiu, Hsiu-Ju; Dai, Xiaoping; Deacon, Ashley M; DiDonato, Michael; Elsliger, Marc-André; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hale, Joanna; Hampton, Eric; Han, Gye Won; Haugen, Justin; Hornsby, Michael; Klock, Heath E; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Jaroszewski, Lukasz; Lesley, Scott A; Levin, Inna; McMullan, Daniel; McPhillips, Timothy M; Miller, Mitchell D; Morse, Andrew; Moy, Kin; Nigoghossian, Edward; Ouyang, Jie; Peti, Wolfgang S; Quijano, Kevin; Reyes, Ron; Sims, Eric; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Vincent, Juli; von Delft, Frank; Wang, Xianhong; West, Bill; White, Aprilfawn; Wolf, Guenter; Xu, Qingping; Zagnitko, Olga.
Proteins ; 58(3): 755-8, 2005 Feb 15.
Article in English | MEDLINE | ID: mdl-15624212

Subject(s)
Crystallography, X-Ray/methods , Hydrolases/chemistry , Saccharomyces cerevisiae Proteins/chemistry , Saccharomyces cerevisiae/metabolism , Serine/chemistry , Amino Acid Sequence , Binding Sites , Computational Biology , Models, Molecular , Molecular Conformation , Molecular Sequence Data , Protein Conformation , Protein Structure, Secondary , Protein Structure, Tertiary , Software
17.
Scalable high-throughput micro-expression device for recombinant proteins.
Page, Rebecca; Moy, Kin; Sims, Eric C; Velasquez, Jeffrey; McManus, Brendan; Grittini, Carina; Clayton, Thomas L; Stevens, Raymond C.
Biotechniques ; 37(3): 364, 366, 368 passim, 2004 Sep.
Article in English | MEDLINE | ID: mdl-15470889

Subject(s)
Escherichia coli/genetics , Proteomics/instrumentation , Recombinant Proteins/biosynthesis , Equipment Design , Escherichia coli/metabolism , Gene Expression , Proteomics/methods , Recombinant Proteins/genetics , Solubility
18.
Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution.
Miller, Mitchell D; Schwarzenbacher, Robert; von Delft, Frank; Abdubek, Polat; Ambing, Eileen; Biorac, Tanya; Brinen, Linda S; Canaves, Jaume M; Cambell, Jamison; Chiu, Hsiu-Ju; Dai, Xiaoping; Deacon, Ashley M; DiDonato, Mike; Elsliger, Marc-André; Eshagi, Said; Floyd, Ross; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hampton, Eric; Jaroszewski, Lukasz; Karlak, Cathy; Klock, Heath E; Koesema, Eric; Kovarik, John S; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; Levin, Inna; McMullan, Daniel; McPhillips, Timothy M; Morse, Andrew; Moy, Kin; Ouyang, Jie; Page, Rebecca; Quijano, Kevin; Robb, Alyssa; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Vincent, Juli; Wang, Xianhong; West, Bill; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 57(1): 213-7, 2004 Oct 01.
Article in English | MEDLINE | ID: mdl-15326606

Subject(s)
Bacterial Proteins/chemistry , Cystathionine beta-Synthase/chemistry , Thermotoga maritima/enzymology , Amino Acid Sequence , Crystallography , Models, Molecular , Molecular Sequence Data , Protein Structure, Secondary , Protein Structure, Tertiary
19.
Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold.
Bakolitsa, Constantina; Schwarzenbacher, Robert; McMullan, Daniel; Brinen, Linda S; Canaves, Jaume M; Dai, Xiaoping; Deacon, Ashley M; Elsliger, Marc-André; Eshagi, Said; Floyd, Ross; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Jaroszewski, Lukasz; Karlak, Cathy; Klock, Heath E; Koesema, Eric; Kovarik, John S; Kreusch, Andreas; Kuhn, Peter; Lesley, Scott A; McPhillips, Timothy M; Miller, Mitchell D; Morse, Andrew; Moy, Kin; Ouyang, Jie; Page, Rebecca; Quijano, Kevin; Robb, Alyssa; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Vincent, Juli; von Delft, Frank; Wang, Xianhong; West, Bill; Wolf, Guenter; Hodgson, Keith O; Wooley, John; Wilson, Ian A.
Proteins ; 56(3): 607-10, 2004 Aug 15.
Article in English | MEDLINE | ID: mdl-15229892

Subject(s)
Bacterial Proteins/chemistry , Thermotoga maritima/chemistry , Amino Acid Sequence , Crystallography, X-Ray , Models, Molecular , Molecular Sequence Data , Multiprotein Complexes , Protein Structure, Secondary , Sequence Homology , Structural Homology, Protein
20.
Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 A resolution.
McMullan, Daniel; Schwarzenbacher, Robert; Jaroszewski, Lukasz; von Delft, Frank; Klock, Heath E; Vincent, Juli; Quijano, Kevin; Abdubek, Polat; Ambing, Eileen; Biorac, Tanya; Brinen, Linda S; Canaves, Jaume M; Dai, Xiaoping; Deacon, Ashley M; DiDonato, Mike; Elsliger, Marc-André; Eshaghi, Said; Floyd, Ross; Godzik, Adam; Grittini, Carina; Grzechnik, Slawomir K; Hampton, Eric; Karlak, Cathy; Koesema, Eric; Kreusch, Andreas; Kuhn, Peter; Levin, Inna; McPhillips, Timothy M; Miller, Mitchell D; Morse, Andrew; Moy, Kin; Ouyang, Jie; Page, Rebecca; Reyes, Ron; Rezezadeh, Fred; Robb, Alyssa; Sims, Eric; Spraggon, Glen; Stevens, Raymond C; van den Bedem, Henry; Velasquez, Jeff; Wang, Xianhong; West, Bill; Wolf, Guenter; Xu, Qingping; Hodgson, Keith O; Wooley, John; Lesley, Scott A; Wilson, Ian A.
Proteins ; 56(3): 615-8, 2004 Aug 15.
Article in English | MEDLINE | ID: mdl-15229894

Subject(s)
Bacterial Proteins/chemistry , Thermotoga maritima/enzymology , Amino Acid Sequence , Binding Sites , Conserved Sequence , Crystallization , Magnetic Resonance Spectroscopy , Models, Molecular , Molecular Sequence Data , Protein Structure, Secondary , Structural Homology, Protein
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