Chromatographic study of local anaesthetics--basic esters of substituted carbanilic acids. II. The relationship between chromatographic values, other physico-chemical parameters and activity.

RM values and the increments delta RM(CH2) have been calculated from the chromatographic values RF of a group of anaesthetics comprising an homologous series of basic esters of substituted carbanilic acids. A linear relationship is demonstrated between RM values from partition chromatography and the partition coefficient (log P) or the substitution constant mu. The chromatographic parameter RM is also correlated with the pharmacological characteristic log U, the logarithm of the surface anaesthetic activity.