ABSTRACT
Bronchial asthma and chronic polypous rhinosinusitis are diseases associated with a T2-inflammatory immune response. These nosologies can be combined, creating the preconditions for a more severe course of multimorbidity, requiring the use of genetic engineering biological therapy. Dupilumab is a monoclonal antibody that can specifically bind to the alpha subunit of the interleukin-4 receptor and block the action of interleukins 4 and 13, which play a key role in the development of T2 inflammation. Numerous studies have demonstrated the high effectiveness of this medicament. The use of dupilumab in some cases may be accompanied by an increase in eosinophils in the blood. This article presents scientific base and our own experience in treating patients with dupilumab-associated eosinophilia, in addition we describe an algorithm for examining this group of patients for the purpose of timely diagnosis of diseases such as eosinophilic granulomatosis with polyangiitis, eosinophilic pneumonia, etc. It should be noted that in the most cases eosinophilia during targeted therapy with dupilumab is temporary and does not cause clinical manifestations.
Subject(s)
Antibodies, Monoclonal, Humanized , Asthma , Eosinophilia , Rhinitis , Sinusitis , Humans , Antibodies, Monoclonal, Humanized/adverse effects , Antibodies, Monoclonal, Humanized/administration & dosage , Antibodies, Monoclonal, Humanized/therapeutic use , Antibodies, Monoclonal, Humanized/pharmacology , Asthma/drug therapy , Eosinophilia/drug therapy , Sinusitis/drug therapy , Rhinitis/drug therapy , Chronic Disease , Nasal Polyps/drug therapy , Nasal Polyps/complications , RhinosinusitisABSTRACT
The present study included 67 patients who had been exposed to the impact of inorganic fluoride compounds. It demonstrated beneficial effect of magnetolaser therapy in combination with whole body iodine-bromide-sodium chlorine baths, physical exercises, and massage on clinical manifestations of the primary disease and concomitant pathologies. Simultaneously, metabolic processes in the articular cartilage and bone tissue were normalized, lipid peroxidation was improved and optimization of antioxidative protection achieved. These changes are indicative of high therapeutic efficiency of the combined treatment employed in this study and its favourable influence on the quality of life of the patients.
Subject(s)
Air Pollutants, Occupational/toxicity , Fluorides/toxicity , Low-Level Light Therapy/methods , Magnetic Field Therapy/methods , Occupational Diseases/therapy , Occupational Exposure/adverse effects , Osteoarthritis/therapy , Humans , Lipid Peroxidation/radiation effects , Male , Middle Aged , Occupational Diseases/chemically induced , Occupational Diseases/radiotherapy , Osteoarthritis/chemically induced , Osteoarthritis/radiotherapy , Quality of Life , Treatment OutcomeABSTRACT
The study in 727 workers exposed to inorganic fluorine compounds revealed through ultrasound densitometry changes in fluorine excretion and bone tissue density in accordance with the length of service, through markers of bone destruction and synthesis features of bone remodelling were specified.
Subject(s)
Air Pollutants, Occupational/adverse effects , Aluminum , Biomarkers/metabolism , Bone Diseases/chemically induced , Bone Marrow/chemistry , Bone Remodeling/drug effects , Fluorine Compounds/adverse effects , Metallurgy , Occupational Diseases/chemically induced , Bone Density/drug effects , Bone Diseases/metabolism , Densitometry , Disease Progression , Fluorine Compounds/pharmacokinetics , Follow-Up Studies , Humans , Male , Middle Aged , Occupational Diseases/metabolism , Risk FactorsABSTRACT
Studies in 45 cryolite production workers (facing chronic gastritis and gastroduodenitis) demonstrated that the diseases in them have moderate inflammatory activity, atrophy of gastric lining contaminated with Helicobacter pylori, hypergastrine mia, hypopancreozymine mia and hyposecretine mia in half of the examinees.
Subject(s)
Duodenitis , Fluorine Compounds/adverse effects , Gastrins/metabolism , Gastritis , Occupational Diseases , Occupational Exposure/adverse effects , Adult , Duodenitis/chemically induced , Duodenitis/epidemiology , Duodenitis/metabolism , Female , Gastritis/chemically induced , Gastritis/epidemiology , Gastritis/metabolism , Helicobacter Infections/epidemiology , Helicobacter pylori , Humans , Hydrogen-Ion Concentration , Male , Middle Aged , Occupational Diseases/chemically induced , Occupational Diseases/diagnosis , Occupational Diseases/epidemiologyABSTRACT
Three methods of ozone therapy (intravenous injection of ozonized physiologic saline, oral intake of ozonized low-mineral water and combination of the two treatments) were compared by efficacy in 215 patients with gastroduodenal pathology associated with Helicobacter pilori. All the techniques of ozone therapy proved effective in relation to regress of clinical symptoms, regeneration processes, eradication of Helicobacter pylori, but the combined regimen was the best.
