[Kidney involvement and arterial hypertension in middle-aged and elderly subjects]. / Porazhenie pochek i arterial'naia gipertoniia u lits pozhilogo i starcheskogo vozrasta.

The examination covered 125 elderly and senile subjects (106 females and 19 males) which made up 90.6% of those living in the boarding house. Their mean age was 81.3 years. Arterial hypertension was detected in 61.6% of the examinees. 18.5% of the examinees had hyperuricemia. Concentration function of the kidneys was affected in all the examinees. Half of them exhibited a moderate rise in the level of blood creatinine. The authors discuss the relationship between high prevalence of arterial hypertension, its tendency to crises and involutional processes in the kidneys in the onset and development of renoprival condition.

Risk factors dynamics in multifactorial prevention of ischaemic heart disease.

The effectiveness of preventive measures in populations subjected to a different degree of preventive activity was according to the dynamics of risk factors (RF) tested in the course of four years. Among 6619 examined men aged 40-59 years, a high incidence of RF (79.2%), their connection with ischaemic heart disease (IHD), and frequent simultaneous incidence of several RF even in subjects without IHD were found. The four-year preventive intervention programme was efficient as regards a decline in the incidence of arterial hypertension (AH) from 24.8% to 19.8%, and smoking from 40.1% to 30.6%, simultaneously with a decrease in the mean level of these RF; these favourable changes did not occur in the control group. Data are analysed concerning the percentage of normalization and the incidence of an elevated BP level, cholesterol and body weight. The study proved the possibility of preventively influencing the incidence of AH in the population, and showed the importance of applying preventive measures in subjects with "borderline" values of RF, such as AH and overweight.

[Bicycle ergometry test results in persons with ischemic heart disease detected in mass screening]. / Rezul'taty veloérgometricheskoi proby u lits s ishemicheskoi bolezn'iu serdtsa, vyiavlennoi pri massovom obsledovanii.

Bicycle ergometry in 40-59 year-old male patients with coronary heart disease, identified during mass prophylactic examination on the basis of epidemiological criteria, has shown that in patients with angina pectoris of effort and no myocardial infarction in history positive exercise tests are observed in 20,8% of cases, while in patients with painless CHD forms positive results are observed in 15.4% of cases. Positive exercise tests are the most often in patients with daily anginal attacks and in those with ST depression and flat negative T waves.

[Adenine uptake in Neurospora crassa mycelium]. / Pogloshchenie adenina mitseliem Neurospora crassa

The uptake of 8-C14-adenine in N. crassa strain Lindegren (+) was studied. The ability of N. crassa cells to uptake adenine from the medium reaches maximum at the very beginning of the logarithmic stage of growth. Adenine enters the mycelium against the concentration gradient. The uptake of adenine is maximal at 25-30 degrees C, pH 4,6-4,8, and adenine concentration in the medium about 2-15X10(-6) M. The entry of adenine into the cells follows normal Michaelis-Menten kinetics, the apparent Km=0.83+/-0.02 micron. The uptake is inhibited at higher concentrations (10(-3)-10(-4) M) of adenine. 2,6-Diaminopurine, hypoxanthine, guanine, 8-azaadenine and 8-azaguanine inhibit the transport of adenine into the cell. Xanthine and cytosine do not affect the uptake of adenine. Adenine taken up into the cell is rapidly metabolized to AMP, ADP and ATP.