ABSTRACT
The study explores the current understanding of the role of macrophages in the process of formation of the regulatory relations in the immune, nervous, and endocrine systems during the immune reactions. Discussion of the effects of the factors of macrophagal origin on the afferent section of the nervous system, on production of neuromediators of the sympathetic and parasympathetic sections of the vegetative nervous system, on production of neuropeptides and the functional activity of adrenals, and of the influence of the neuroendocrine system on the mononuclear phagocytes. Discussion of the role of macrophages in the intersystem regulation of the immune reaction.
Subject(s)
Antigen-Antibody Reactions/immunology , Endocrine Glands/immunology , Macrophages/immunology , Neuroimmunomodulation/immunology , Adrenal Glands/immunology , Animals , Interleukin-1/immunology , Monokines/immunology , Neurosecretory Systems/immunologySubject(s)
Ankle Joint , Knee Joint , Leg Injuries/blood , Leg/blood supply , Osteoarthritis/blood , Osteomyelitis/blood , Prostaglandins E/blood , Wound Infection/blood , Adult , Humans , Leg Injuries/complications , Leg Injuries/surgery , Middle Aged , Osteoarthritis/etiology , Osteoarthritis/surgery , Osteomyelitis/etiology , Osteomyelitis/surgery , Postoperative Care , Wound Infection/etiology , Wound Infection/surgeryABSTRACT
In 25 healthy subjects and 47 patients with RA production of interleukin-1 was studied. Increase in the production of interleukin-1 in the supernatants of nonstimulated monocyte cultures was observed in RA patients and more frequently in patients with high activity of the inflammatory process.
Subject(s)
Arthritis, Rheumatoid/immunology , Interleukin-1/analysis , Adult , Animals , Cells, Cultured/drug effects , Cells, Cultured/immunology , Chronic Disease , Humans , Indomethacin/pharmacology , Mice , Mice, Inbred BALB C , Middle Aged , Monocytes/analysis , Monocytes/drug effects , Monocytes/immunology , Synovial Fluid/analysis , Synovial Fluid/immunologySubject(s)
Aspirin/administration & dosage , Fibula/injuries , Fractures, Open/surgery , Prostaglandins E/antagonists & inhibitors , Surgical Wound Infection/prevention & control , Tibial Fractures/surgery , Femoral Artery/drug effects , Fibula/surgery , Humans , Infusions, Intra-Arterial , Preoperative Care , Prostaglandin Antagonists , Surgical Wound Infection/etiologyABSTRACT
The influence of macrophage secretion product on the functional activity of the adrenal glands has been studied in mice. It has been shown that intravenously injected interleukin-1 caused dose-dependent increase in corticosterone content in the blood plasma. The hormonal response of the adrenal glands to interleukin-1 injection was abolished by the inhibition of prostaglandin synthesis. The results obtained indicate that interleukin-1 stimulates the functional activity of the adrenal glands, with the effect mediated by prostaglandins.
Subject(s)
Adrenal Glands/drug effects , Interleukin-1/pharmacology , Adrenal Glands/physiology , Animals , Antibody Formation , Corticosterone/blood , Interleukin-1/metabolism , Macrophages/immunology , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBASubject(s)
Bone Marrow/drug effects , Hematopoietic Stem Cells/drug effects , Prostaglandins E/pharmacology , Spleen/drug effects , Animals , Bone Marrow Cells , Cell Division/drug effects , Cell Movement/drug effects , Dinoprostone , Hematopoietic Stem Cells/cytology , Indomethacin/pharmacology , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Prostaglandins E/antagonists & inhibitors , Spleen/cytology , Time FactorsABSTRACT
The influence of exogenous prostaglandin E2 on different stages of the immune response to sheep red blood cells was studied in (CBA x C57BL) F1 mouse hybrids. It was shown that prostaglandin E2 in a dose of 10(-6) M given 72 h after antigen challenge increased the number of the plaque-forming cells. Prostaglandin E2 stimulated antibody formation on being injected to mice in doses 10(-6) M--5 . 10(-4) M 24 and 2 h prior to antigen challenge. Prostaglandin E2 enhanced endogenous colony formation when injected to mice 24 and 2 h prior to sublethal irradiation. It is suggested that prostaglandins regulate different stages of the immune response.
Subject(s)
Antibody Formation/drug effects , Prostaglandins E/immunology , Animals , Antibody-Producing Cells/drug effects , Colony-Forming Units Assay , Dinoprostone , Immunization , Indomethacin/immunology , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBAABSTRACT
The effect of hydrocortisone under conditions of blockade of the mononuclear phagocyte system (MPS) on antibody response in mice has been studied. The injection of hydrocortisone 4 and 48 hours before SRBC immunization suppressed humoral immune response. No increase in the suppression of immune response was observed after the injection of hydrocortisone under condition of MPS blockade. Hydrocortisone is supposed to affect, at least under the given experimental conditions, the macrophage stage of immunogenesis.
Subject(s)
Antibody-Producing Cells/drug effects , Hydrocortisone/pharmacology , Immunosuppressive Agents , Phagocytes/immunology , Spleen/immunology , Animals , Erythrocytes/immunology , Hybridization, Genetic , Ink , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Sheep/immunologyABSTRACT
The endogenous colony formation and immunogenesis in mice of CBA and C57BL strains immunized with various doses of sheep red blood cells (SRBC) were studied. An absolute or relative increase of antibody forming cells under the action of growing SRBC dose from 2.10(7) to 2.10(8) as well as a decrease following 2.10(9) dose administration were noted. The number of endogenous hemopoietic spleen colonies augmented depending on increased antigen dose. Strain differences in the number of endogenous spleen colonies remained. It is suggested that the stimulation mode of hemopoietic lines is based on a specific RES blockade by SRBC resulting in enhanced proliferative effect of stem cells.
