1.
Prenat Diagn
; 12(1): 53-9, 1992 Jan.
Article
in English
| MEDLINE
| ID: mdl-1557311
ABSTRACT
Metaphase chromosomes and interphase nuclei of chorionic villus samples (CVS) in five cases were studied after treatment with trypsin and post-fixation in formaldehyde by chromosomal in situ suppression (CISS) hybridization. Our modified protocol enables the use of in situ hybridization techniques on CVS preparations after 42 h of culture. A balanced translocation and trisomy 13 were identified with the aid of CISS hybridization.