Estudio de la difusión de la luz mediante C-Quant(R) en pacientes con distrofia endotelial de Fuchs: un estudio piloto / of light scattering using C-Quant(R) in patients with Fuchs' endothelial dystrophy: A pilot study

Objetivo: La finalidad de este trabajo fue determinar la difusión de la luz en pacientes con distrofia endotelial de Fuchs sin edema corneal clínicamente significativo, y evaluar su relación con el recuento de células endoteliales, paquimetría y parámetros biomecánicos corneales. Materiales y métodos: Los valores de difusión de la luz fueron medidos usando el C-Quant(R) (Oculus Optikgeräte GmbH, Alemania) en 32 ojos de 17 pacientes diagnosticados de distrofia endotelial de Fuchs sin edema corneal clínicamente significativo. Las propiedades biomecánicas corneales fueron determinadas usando ORA y Corvis ST(R). Resultados: El 93,8% de los ojos estudiados mostraron un valor de difusión de la luz fuera del rango normal. No se encontró ninguna correlación estadísticamente significativa (p > 0,05) entre los valores de difusión de la luz medidos mediante el C-Quant(R) y el recuento endotelial, la paquimetría o las propiedades biomecánicas corneales. Conclusiones: En nuestro estudio encontramos una alteración en los valores de difusión de la luz de los pacientes con distrofia endotelial de Fuchs. Esta alteración no parece correlacionarse significativamente con la gravedad de la enfermedad (AU)

Objective: The purpose of this study was to determine the light scattering in patients with Fuchs' endothelial dystrophy without clinically significant corneal oedema, and evaluate its relationship with endothelial cell count, corneal thickness, and corneal biomechanical parameters. Materials and methods: The values of light scattering were measured by C-Quant(R) (Oculus Optikgeräte GmbH, Germany) in 32 eyes of 17 patients diagnosed with Fuchs' endothelial dystrophy without clinically significant corneal oedema. Corneal biomechanical properties were determined using ORA (ocular response) and Corvis ST(R) (tonometry). Results: A light scattering value outside the normal range was observed in 93.8% of eyes studied. No statistically significant association (P>.05) was found between the values of the measured light scattering by C-Quant(R) and endothelial count, pachymetry, or corneal biomechanical properties. Conclusions: In this study, changes were found in the values of light scattering values of patients with corneal Fuchs' endothelial dystrophy. This change does not appear to correlate significantly with disease severity (AU)

Study of light scattering using C-Quant® in patients with Fuchs' endothelial dystrophy: A pilot study. / Estudio de la difusión de la luz mediante C-Quant® en pacientes con distrofia endotelial de Fuchs: un estudio piloto.

OBJECTIVE: The purpose of this study was to determine the light scattering in patients with Fuchs' endothelial dystrophy without clinically significant corneal oedema, and evaluate its relationship with endothelial cell count, corneal thickness, and corneal biomechanical parameters. MATERIALS AND METHODS: The values of light scattering were measured by C-Quant® (Oculus Optikgeräte GmbH, Germany) in 32 eyes of 17 patients diagnosed with Fuchs' endothelial dystrophy without clinically significant corneal oedema. Corneal biomechanical properties were determined using ORA (ocular response) and Corvis ST® (tonometry). RESULTS: A light scattering value outside the normal range was observed in 93.8% of eyes studied. No statistically significant association (P>.05) was found between the values of the measured light scattering by C-Quant® and endothelial count, pachymetry, or corneal biomechanical properties. CONCLUSIONS: In this study, changes were found in the values of light scattering values of patients with corneal Fuchs' endothelial dystrophy. This change does not appear to correlate significantly with disease severity.

Effects of pterygium on the biomechanical properties of the cornea: a pilot study.

OBJECTIVE: To investigate the changes induced by a pterygium or its surgical removal on the biomechanical properties of the cornea and to determine factors that might affect these parameters. METHODS: This prospective pilot interventional, non-randomized, observer-masked study included 20 eyes of 20 patients with a unilateral primary pterygium (pterygium group) and 19 fellow healthy eyes (control group). The bare sclera technique with one-minute application of 0.02% mitomycin C intraoperatively was performed in all cases. The follow-up period was one month. The preoperative and postoperative biomechanical properties of the cornea were measured using the Reichert ocular response analyzer (ORA). RESULTS: The corneal hysteresis (CH) decreased significantly (P<.01) in eyes with a pterygium compared to the control eyes, while surgery did not significantly change the CH compared to preoperatively. There were no significant changes in the corneal resistance factor or the central corneal thickness. CONCLUSIONS: Primary active pterygium (grades 1 or 2) induce a reduction of corneal biomechanical features. Further studies are needed in populations, with longer follow-ups and bigger pterygium that may involve wider keratectomy to confirm our results.

Efecto del pterigión en las propiedades biomecánicas de la córnea: estudio piloto / Effects of pterygium on the biomechanical properties of the cornea: a pilot study

Objetivo: Investigar los cambios inducidos en la biomecánica de la córnea por la presencia de pterigión o por su exéresis quirúrgica, así como determinar los factores que influyen sobre dichos parámetros. Métodos: Estudio piloto, intervencional y prospectivo, con observador enmascarado que incluía 20 ojos de 20 pacientes con pterigión primario unilateral (grupo pterigión) y 19 ojos adelfos sanos (grupo control). Se realizó una resección simple del pterigión con aplicación intraoperatoria de mitomicina C 0,02% durante un minuto sobre el lecho escleral. El periodo de seguimiento fue de un mes. Las propiedades biomecánicas de la córnea fueron determinadas preoperatoria y postoperatoriamente mediante el analizador de respuesta ocular Reichert (ORA). Resultados: La presencia de pterigión disminuyó significativamente la histéresis corneal (HC) en comparación con el grupo control (p<0,01). No encontramos diferencias estadísticamente significativas entre las medidas pre- y postoperatorias de la HC, del factor de resistencia corneal, ni del espesor corneal central. Conclusión: La presencia de un pterigión primario activo (grados 1 y 2) conduce a una reducción de las propiedades biomecánicas de la córnea. Serían necesarios nuevos estudios con un mayor tiempo de seguimiento y pterigiones más avanzados, con queratectomías más amplias para confirmar estos efectos(AU)

Objective: To investigate the changes induced by a pterygium or its surgical removal on the biomechanical properties of the cornea and to determine factors that might affect these parameters. Methods: This prospective pilot interventional, non-randomized, observer-masked study included 20 eyes of 20 patients with a unilateral primary pterygium (pterygium group) and 19 fellow healthy eyes (control group). The bare sclera technique with one-minute application of 0.02% mitomycin C intraoperatively was performed in all cases. The follow-up period was one month. The preoperative and postoperative biomechanical properties of the cornea were measured using the Reichert ocular response analyzer (ORA). Results: The corneal hysteresis (CH) decreased significantly (P<0.01) in eyes with a pterygium compared to the control eyes, while surgery did not significantly change the CH compared to preoperatively. There were no significant changes in the corneal resistance factor or the central corneal thickness. Conclusions: Primary active pterygium (grades 1 or 2) induce a reduction of corneal biomechanical features. Further studies are needed in populations, with longer follow-ups and bigger pterygium that may involve wider keratectomy to confirm our results(AU)

[Central corneal thickness in a healthy Spanish population]. / Espesor corneal central en una población sana española.

OBJECTIVE: To study the central corneal thickness of a Spanish population group and determine the influence of age, gender, axial length and refractive error on central corneal thickness (CCT) values. METHODS: An observational, cross-sectional, double masked study was conducted on 357 eyes of consecutive Caucasian patients without ophthalmic disease. They were distributed according to age, and high refractive defects were excluded. Ultrasonic pachymetry and a complete eye examination were performed on all patients. The relationship between the central corneal thickness values and variables of age, refractive error, axial length and gender was assessed. RESULTS: The mean central corneal thickness was 548.21 µm with a standard deviation (SD) of 30.7 µm (range 464 to 633 µm). The normal central corneal thickness value of the population studied was 486.81 to 609.61 µm (95% confidence interval). No statistical association was found between central corneal thickness values and variables of age, refractive error, axial length and gender. CONCLUSIONS: Central corneal thickness varies according to race. We have analysed, for the first time, normal central corneal thickness values of a healthy Spanish population.

Espesor corneal central en una población sana española / Central corneal thickness in a healthy Spanish population

Objetivo: Estudiar el valor del espesor corneal central (ECC) en población sana española y surelación con la edad, el sexo, la longitud axial y la refracción.Método: En este estudio observacional transversal enmascarado incluimos pacientes consecutivosde raza caucásica, sin enfermedad ocular conocida. Se seleccionó un total de 357ojos, repartidos homogéneamente por décadas etarias, excluyendo defectos de refracciónaltos. Se realizó una paquimetría ultrasónica central de múltiples tomas y una exploraciónoftalmológica completa por el mismo evaluador. Se analizaron los valores medios de ECC,edad, refracción y longitud axial y la relación existente entre el ECC y la longitud axial, elsexo, la edad y el defecto refractivo.Resultados: El espesor corneal central medio obtenido (media +/- desviación estándar) fue548,21 +/- 30,7 m con un rango de 464 a 633 m. El valor normal del espesor corneal centralen nuestra población fue de 486,81 a 609,61m (intervalo de confianza del 95%). No seencontró asociación estadística entre el ECC y la edad, el sexo, la longitud axial ni el defectorefractivo.Conclusión: El espesor corneal central es un parámetro que presenta variación racial. Este esel primer estudio que aporta valores normales de espesor corneal central en población sanaespañola(AU)

Objective: To study the central corneal thickness of a Spanish population group and determinethe influence of age, gender, axial length and refractive error on central cornealthickness (CCT) values.Methods: An observational, cross-sectional, double masked study was conducted on 357eyes of consecutive Caucasian patients without ophthalmic disease. They were distributedaccording to age, and high refractive defects were excluded. Ultrasonic pachymetry and a complete eye examination were performed on all patients. The relationship betweenthe central corneal thickness values and variables of age, refractive error, axial length andgender was assessed.Results: The mean central corneal thickness was 548.21 mwith a standard deviation (SD) of30.7 m(range 464 to 633 m). The normal central corneal thickness value of the populationstudied was 486.81 to 609.61 m (95% confidence interval). No statistical association wasfound between central corneal thickness values and variables of age, refractive error, axiallength and gender.Conclusions: Central corneal thickness varies according to race. We have analysed, for thefirst time, normal central corneal thickness values of a healthy Spanish population(AU)

Uveítis anterior bilateral aguda e hipersensibilidad a anticonvulsivantes / Bilateral acute anterior uveitis and anticonvulsant hypersensitivity syndrome

Caso clínico: Se presenta el caso de una paciente que tras la toma de oxcarbacepina (trileptal) desarrolló lesiones cutáneas en miembros inferiores y una uveítis anterior bilateral.DiscusiónLa presencia de uveítis en el contexto de una reacción alérgica a un anticonvulsivante es un hecho poco frecuente que traduce una afectación de órganos internos, por lo que debe ser tenida en cuenta en la valoración completa de un paciente con posible reacción de hipersensibilidad a un determinado fármaco (AU)

Clinical Case: A case is presented of a patient who developed skin lesions on the legs and a bilateral anterior uveitis after taking Oxcarbazepine (Trileptal)DiscussionThe presence of uveitis in the context of an allergic reaction to an anticonvulsant is a very uncommon and can affect the internal organs. For this reason, it should be taken into account when carrying out a full assessment of a patient with a possible hypersensitivity reaction to a particular drug (AU)

[Management of subretinal hemorrhage with r-TPA, SF-6 and ranibizumab]. / Tratamiento de una hemorragia subretiniana con r-TPA, SF6 y ranibizumab.

CASE REPORT: We present a case of a patient with subretinal hemorrhage treated with intravitreal r-TPA, SF-6 and ranibizumab. DISCUSSION: Subretinal hemorrhages secondary to age-related macular degeneration are associated with poor visual outcome. A wide variety of management approaches has been developed, but the prognosis of these patients has not been modified by any of them. The association of an intravitreal anti VEGF drug to r-TPA and gas, may improve its results as we add the treatment of the subjacent etiology to the pneumatic displacement.

Tratamiento de una hemorragia subretiniana con r-TPA, SF6 y ranibizumab / Management of subretinal hemorrhage with r-TPA, SF-6 and ranibizumab

Caso clínico: Se presenta el caso de un paciente con hemorragia subretiniana por degeneraciónmacular asociada a la edad (DMAE) tratada con activador del plasminógeno tisularrecombinante (r-TPA), hexafluoruro de azufre y ranibizumab.Discusión: Las hemorragias subretinianas secundarias a DMAE tienen mal pronóstico visual.A pesar de la gran cantidad de opciones terapéuticas planteadas para este proceso,ninguna ha conseguido mejorarlo. El desplazamiento de la hemorragia subretiniana conr-TPA y gas se ha aplicado en el tratamiento de esta afección. La asociación de un fármacoanti-VEGF intravítreo a esta técnica puede mejorar los resultados, al asociar un componenteterapéutico al desplazamiento físico de la hemorragia(AU)

Case report: We present a case of a patient with subretinal hemorrhage treated withintravitreal r-TPA, SF-6 and ranibizumab.Discussion: Subretinal hemorrhages secondary to age-related macular degeneration areassociated with poor visual outcome. A wide variety of management approaches has beendeveloped, but the prognosis of these patients has not been modified by any of them. Theassociation of an intravitreal anti VEGF drug to r-TPA and gas, may improve its results aswe add the treatment of the subjacent etiology to the pneumatic displacement(AU)

[Bilateral acute anterior uveitis and anticonvulsant hypersensitivity syndrome]. / Uveítis anterior bilateral aguda e hipersensibilidad a anticonvulsivantes.

CLINICAL CASE: A case is presented of a patient who developed skin lesions on the legs and a bilateral anterior uveitis after taking Oxcarbazepine (Trileptal). DISCUSSION: The presence of uveitis in the context of an allergic reaction to an anticonvulsant is a very uncommon and can affect the internal organs. For this reason, it should be taken into account when carrying out a full assessment of a patient with a possible hypersensitivity reaction to a particular drug.